Young-Ju Lee
Hanyang University · Medicine
About the Lab
Professor Young-Ju Lee's research lab specializes in translational biomedical engineering and clinical oncology, focusing on advanced medical imaging, liver transplantation surgery, and molecular oncology. The lab investigates innovative imaging techniques—such as multi-echo MRI and FDG-PET/CT—for accurate quantification of hepatic fat and tumor metabolism, while also exploring novel therapeutic strategies for drug-resistant cancers using HDAC inhibitors like SAHA. A significant emphasis is placed on improving surgical outcomes in living-donor liver transplantation, particularly in complex anatomical variants such as anomalous portal venous branching. The lab integrates clinical practice with rigorous mathematical modeling to enhance the understanding and treatment of liver diseases and cancer.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Preservation and reconstruction of the MHV tributaries is recommended to prevent congestion of the right liver graft without MHV.
OBJECTIVE: Tamoxifen is currently used for the treatment of estrogen receptor-positive breast cancer patients, but acquired resistance to tamoxifen is a critical problem in breast cancer therapy. Suberoylanilide hydroxamic acid (SAHA) is a prototype of the newly developed HDAC inhibitor. The aim of this study is to investigate the anticancer effects of SAHA in tamoxifen-resistant MCF-7 (TAMR/MCF-7) cells. METHODS: Cytotoxicity, apoptosis and autophagic cell death induced by SAHA were studied. A
The multiecho and multi-interference MRI methods and MRS can accurately quantify hepatic fat, with coexisting histologic abnormalities having no confounding effects.
PURPOSE: We investigated the prognostic effect of incorporating metabolic assessment by (18)F-fluoro-2-deoxyglucose uptake on positron emission tomography/computed tomography ((18)F-FDG-PET/CT) into a conventional staging system in small-cell lung cancer (SCLC). EXPERIMENTAL DESIGN: Seventy-six consecutive patients with pathologically proven SCLC were enrolled. All patients underwent standard treatment after pretreatment (18)F-FDG-PET/CT scanning. The mean values of maximal standardized uptake v
Right lobe living-donor liver transplantation (LDLT) is often not attempted in donors with anomalous portal venous branching (APVB). The authors describe their experience with portal vein (PV) reconstruction in 17 cases of APVB in right lobe LDLT. From July 1997 to December 2001, 214 right liver LDLT were performed at the Asan Medical Center. Seventeen of the donors had APVB and successfully underwent right lobectomy. The APVB were type II (trifurcation) in nine cases, type III (independent post
In this paper, we discuss convergence results for general (successive) subspace correction methods for solving nearly singular systems of equations. We provide parameter independent estimates under appropriate assumptions on the subspace solvers and space decompositions. The main assumption is that any component in the kernel of the singular part of the system can be decomposed into a sum of local (in each subspace) kernel components. This assumption also covers the case of "hidden" nearly singu
OBJECTIVES: Glucose homeostasis changes after pancreatic resection are not well understood. We aimed to identify the incidence of, and risk factors for, a change in glucose homeostasis in patients who underwent pancreatectomy for benign pancreatic tumors. METHODS: Clinical and pathological data from 229 patients were collected prospectively and analyzed retrospectively. The pancreas resection volume was calculated by computed tomography volumetry. RESULTS: After pancreatectomy, newly diagnosed d
Research Areas
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