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Young Seo Kim

Hanyang University · Medicine

About the Lab

Professor Young Seo Kim's research lab focuses on cancer biology and glycobiology, with a particular emphasis on the role of carbohydrate antigens and glycoproteins in colorectal and pancreatic cancers. The lab investigates tumor-associated carbohydrate antigens such as LeY, LeX, and sialyl Lewis X, exploring their expression patterns and biological significance in cancer progression and metastasis. Additionally, the lab examines the effects of bioactive compounds like sodium butyrate and DMSO on cancer cell differentiation and tumorigenicity, as well as the physicochemical properties of plant polysaccharides with potential biomedical applications. These studies aim to uncover novel biomarkers and therapeutic targets for gastrointestinal cancers.

glycobiologytumor-associated antigenscolorectal cancermucinscarbohydrate antigens

Research Overview

Papers
237
Total Citations
3,762
Papers (5y)
78
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
78total
2022
2023
2024
2025
2026
Citations per year (5y)
250total
20222023202420252026

Selected Papers

15
1
Article|198 citations·1995
Screening Potato Starch for Novel Properties Using Differential Scanning Calorimetry
Young Seo Kim, Dennis P. Wiesenborn, P. H. Orr, L. A. Grant
SJR Q1Journal of Food Science

ABSTRACT T hermal and other physicochemical properties of starch from 42 potato genotypes were studied to find those with unique properties for food use, and to analyze relationships between thermal and other physicochemical properties. Onset and peak transition temperatures and gelatinization enthalpy intercorrelated. Transition temperatures intercorrelated with pasting temperature using a Brabender Visco‐amylograph. Gelatinization entbalpy correlated with Brabender pasting temperature and peak

Nutrition and DieteticsNursing
2
Article|137 citations·2011
Stroke awareness decreases prehospital delay after acute ischemic stroke in korea
Young Seo Kim, Sang‐Soon Park, Hee‐Joon Bae, A-Hyun Cho, Yong‐Jin Cho, Moon‐Ku Han, Ji Hoe Heo, Kyusik Kang, Dong‐Eog Kim, Hahn Young Kim, Gyeong‐Moon Kim, Sun Uk Kwon
SJR Q2BMC NeurologyOA

BACKGROUND: Delayed arrival at hospital is one of the major obstacles in enhancing the rate of thrombolysis therapy in patients with acute ischemic stroke. Our study aimed to investigate factors associated with prehospital delay after acute ischemic stroke in Korea. METHODS: A prospective, multicenter study was conducted at 14 tertiary hospitals in Korea from March 2009 to July 2009. We interviewed 500 consecutive patients with acute ischemic stroke who arrived within 48 hours. Univariate and mu

EpidemiologyMedicine
3
Article|103 citations·2003
Aberrant Expression of MUC3 and MUC4 Membrane-Associated Mucins and Sialyl Lex Antigen in Pancreatic Intraepithelial Neoplasia
Hee–Ug Park, Jong‐Woo Kim, Grace Kim, Han‐Ik Bae, Suzanne Crawley, Stacey C. Yang, James R. Gum, Surinder K. Batra, Karine Rousseau, Dallas M. Swallow, Marvin H. Sleisenger, Young Seo Kim
SJR Q2Pancreas

Aberrant expression of membrane mucins MUC3 and MUC4 and of a mucin-associated carbohydrate tumor antigen Sialyl Le(x) in PanINs and adenocarcinoma further supports the progression model for pancreatic adenocarcinoma.

OncologyMedicine
4
Article|101 citations·1972
Glycosyltransferases in human blood
Young Seo Kim, Jose Perdomo, James S. Whitehead
SJR Q1Journal of Clinical InvestigationOA

Human serum and hemoglobin-free erythrocyte membranes were found to contain a galactosyltransferase which catalyzes the transfer of galactose from UDP-galactose to specific large and small molecular weight acceptors. The requirements for enzyme activity were found to be similar for the enzymes from both sources. However, the membrane-bound enzyme depended on a detergent for maximal activity. Mn(++) was an absolute requirement for transfer and uridine nucleoside phosphates were inhibitors. The mo

SurgeryMedicine
5
Article|60 citations·2012
The advantage of high-resolution MRI in evaluating basilar plaques: A comparison study with MRA
Young Seo Kim, Sunghwan Lim, Ki‐Wook Oh, Ji Young Kim, Seong‐Ho Koh, Juhan Kim, Sung Hyuk Heo, Dae‐Il Chang, Young‐Jun Lee, Hyun Young Kim
SJR Q1Atherosclerosis
Pulmonary and Respiratory MedicineMedicine
6
Article|57 citations·2011
Public Awareness of Stroke in Korea
Young Seo Kim, Sang-Soon Park, Hee‐Joon Bae, Ji Hoe Heo, Sun U. Kwon, Byung‐Chul Lee, Seung‐Hoon Lee, Chang Wan Oh, Byung‐Woo Yoon
SJR Q1StrokeOA

BACKGROUND AND PURPOSE: To date, no large study has been conducted to investigate baseline stroke awareness within a nationally representative sample of the Korean population. METHODS: A total of 1000 residents were randomly sampled according to regional demographic characteristics and were interviewed in person by trained interviewers. Structured, open-ended and close-ended questions were asked to assess stroke awareness. RESULTS: Among the respondents, 62% reported at least 1 stroke symptom an

EpidemiologyMedicine
7
Article|50 citations·2018
Regulatory T cells increase after treatment with poly (ADP-ribose) polymerase-1 inhibitor in ischemic stroke patients
Min‐Young Noh, Won Moo Lee, Su Jung Lee, Hyun Young Kim, Seung Hyun Kim, Young Seo Kim
SJR Q1International Immunopharmacology
NeurologyNeuroscience
8
Article|48 citations·2014
Hypoxia/Reoxygenation-Preconditioned Human Bone Marrow-Derived Mesenchymal Stromal Cells Rescue Ischemic Rat Cortical Neurons by Enhancing Trophic Factor Release
Young Seo Kim, Min‐Young Noh, Kyung‐Ah Cho, Hyemi Kim, Min‐Soo Kwon, Kyung Suk Kim, Juhan Kim, Seong‐Ho Koh, Seung Hyun Kim
SJR Q1Molecular Neurobiology
GeneticsMedicine
9
Article|42 citations·1978
Determination of free Ca ion concentrations with an ion-selective electrode in the presence of chelating agents in comparison with calculated values
Young Seo Kim, George M. Padilla
SJR Q3Analytical Biochemistry
BioengineeringChemical Engineering
10
Article|41 citations·2006
The Role of Matrix Metalloproteinase 9 in Early Neurological Worsening of Acute Lacunar Infarction
Young Seo Kim, Kyu‐Yong Lee, Seong‐Ho Koh, Chang Yun Park, Ho Kim, Young Joo Lee, Hee-Tae Kim, Juhan Kim, Myung‐Ho Kim, Kyung Suk Kim, Dae‐Il Chang, Seung Hyun Kim
SJR Q3European Neurology

The involvement of matrix metalloproteinases (MMPs) in ischemic-stroke-induced inflammatory response has recently been suggested; however, the relationship between MMPs and stroke progression has not been evaluated. We investigated the role of MMPs in neurological worsening of acute lacunar infarction. Forty-nine consecutive patients with an acute lacunar infarction (as defined by clinical and MRI criteria within 48 h after stroke onset) were evaluated. Clinical, biochemical, rheological, inflam

Cancer ResearchBiochemistry, Genetics and Molecular Biology
11
Article|38 citations·2013
Direct GSK-3β Inhibition Enhances Mesenchymal Stromal Cell Migration by Increasing Expression of Beta-PIX and CXCR4
Young Seo Kim, Min‐Young Noh, Ji Young Kim, Hyun‐Jeung Yu, Kyung Suk Kim, Seung Hyun Kim, Seong‐Ho Koh
SJR Q1Molecular Neurobiology
GeneticsMedicine
12
Article|33 citations·2017
Range of glucose as a glycemic variability and 3–month outcome in diabetic patients with acute ischemic stroke
Young Seo Kim, Chulho Kim, Keun‐Hwa Jung, Hyung‐Min Kwon, Sung Hyuk Heo, Beom Joon Kim, Young Dae Kim, Jeong‐Min Kim, Seung‐Hoon Lee
SJR Q1PLoS ONEOA

Glycemic variability (GV) is reportedly a predictor for poor outcome in various clinical conditions. We aimed to assess whether GV during hospital admission is associated with poor outcomes in patients with acute ischemic stroke (AIS) and diabetes. We prospectively enrolled consecutive patients with AIS from the registry of 6 tertiary hospitals between January 2013 and December 2014. For the GV index, we used a glucose level range that was divided into 4 quartiles. Multivariable binary and ordin

EpidemiologyMedicine
13
Article|29 citations·1974
Effects of salinity on synthesis of DNA, acidic polysaccharide, and ichthyotoxin in Gymnodinium breve
Young Seo Kim, Dean F. Martin
SJR Q1Phytochemistry
Environmental ChemistryEnvironmental Science
14
Article|28 citations·2019
Distal versus Proximal Middle Cerebral Artery Occlusion: Different Mechanisms
Young Seo Kim, Bum Joon Kim, Kyung Chul Noh, Kyung Mi Lee, Sung Hyuk Heo, Hye‐Yeon Choi, Hyun Young Kim, Seong‐Ho Koh, Dae‐Il Chang
SJR Q2Cerebrovascular Diseases

BACKGROUND: Clinical and radiological characteristics of middle cerebral artery (MCA) infarction may differ according to the location of occlusion. OBJECTIVES: We investigated the difference between proximal and distal symptomatic MCA occlusion (MCAO) in patients with ischemic stroke. The factors associated with the imaging characteristics were also analyzed. METHODS: Patients with ischemic stroke due to MCAO were consecutively enrolled. The location of MCAO was determined by the ratio of the le

EpidemiologyMedicine
15
Article|24 citations·2016
Early Activation of Phosphatidylinositol 3-Kinase after Ischemic Stroke Reduces Infarct Volume and Improves Long-Term Behavior
Young Seo Kim, Arum Yoo, Jeong Woo Son, Hyun Young Kim, Young‐Jun Lee, Se Jin Hwang, Kyu‐Yong Lee, Young Joo Lee, Cenk Ayata, Hyung-Hwan Kim, Seong‐Ho Koh
SJR Q1Molecular Neurobiology
Geriatrics and GerontologyMedicine

Research Areas

OncologyNeurologyEpidemiologyRheumatologyPulmonary and Respiratory MedicineAtomic and Molecular Physics, and Optics

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