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Yujin Lim

Kyung Hee University · Medicine

About the Lab

Professor Yujin Lim's research lab specializes in translational oncology and cancer therapeutics, with a focus on improving outcomes in head and neck, breast, and gastrointestinal cancers through radiation oncology, biomarker discovery, and novel therapeutic strategies. The lab investigates prognostic factors, treatment response, and mechanisms of resistance in locally advanced and early-stage cancers, integrating clinical data with molecular and preclinical models. Key research directions include radiosensitization, the role of growth factors like EGF in tumor response, and the development of predictive nomograms for metastatic risk and survival. The lab also explores natural compounds with anti-cancer and neuroprotective properties, such as those found in kiwifruits, for potential chemopreventive applications.

radiation oncologyprognostic biomarkerscancer therapeuticstreatment responsenatural antioxidants

Research Overview

Papers
73
Total Citations
933
Papers (5y)
26
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
26total
2021
2022
2023
2024
2025
Citations per year (5y)
137total
20212022202320242025

Selected Papers

15
1
Article|86 citations·2017
Chemoradiation-Induced Alteration of Programmed Death-Ligand 1 and CD8+ Tumor-Infiltrating Lymphocytes Identified Patients With Poor Prognosis in Rectal Cancer: A Matched Comparison Analysis
Yu Jin Lim, Jaemoon Koh, Sehui Kim, Sang-Rok Jeon, Eui Kyu Chie, Kyubo Kim, Gyeong Hoon Kang, Sae‐Won Han, Tae‐You Kim, Seung‐Yong Jeong, Kyu Joo Park, Hong-Gyun Wu
SJR Q1International Journal of Radiation Oncology*Biology*Physics
OncologyMedicine
2
Article|58 citations·2015
High ratio of programmed cell death protein 1 (PD-1)+/CD8+ tumor-infiltrating lymphocytes identifies a poor prognostic subset of extrahepatic bile duct cancer undergoing surgery plus adjuvant chemoradiotherapy
Yu Jin Lim, Jaemoon Koh, Kyubo Kim, Eui Kyu Chie, BoKyong Kim, Kyoung Bun Lee, Jin‐Young Jang, Sun‐Whe Kim, Do‐Youn Oh, Yung‐Jue Bang, Sung Whan Ha
SJR Q1Radiotherapy and Oncology
OncologyMedicine
3
Review|52 citations·2016
Survival Impact of Adjuvant Radiation Therapy in Masaoka Stage II to IV Thymomas: A Systematic Review and Meta-analysis
Yu Jin Lim, Eunji Kim, Hak Jae Kim, Hong-Gyun Wu, Jinchun Yan, Qin Liu, Shilpen Patel
SJR Q1International Journal of Radiation Oncology*Biology*Physics
NeurologyMedicine
4
Article|50 citations·2015
Role of Postoperative Radiotherapy in Nonlocalized Thymoma
Yu Jin Lim, Hak Jae Kim, Hong‐Gyun Wu
SJR Q1Journal of Thoracic OncologyOA
NeurologyMedicine
5
Article|44 citations·2015
Long-Term Outcome of Definitive Radiotherapy for Early Glottic Cancer: Prognostic Factors and Patterns of Local Failure
Yu Jin Lim, Hong-Gyun Wu, Tack‐Kyun Kwon, J. Hun Hah, Myung‐Whun Sung, Kwang Hyun Kim, Charn Il Park
SJR Q1Cancer Research and TreatmentOA

PURPOSE: This study evaluates the long-term results of definitive radiotherapy (RT) for early glottic cancer. Clinical and treatment factors related to local control and patterns of failure are analyzed. MATERIALS AND METHODS: We retrospectively reviewed 222 patients with T1-2N0 squamous cell carcinoma of the glottic larynx treated with definitive RT from 1981 to 2010. None of the patients received elective nodal RT or combined chemotherapy. The median total RT dose was 66 Gy. The daily fraction

OtorhinolaryngologyMedicine
7
Article|34 citations·2014
Physiological Components of Kiwifruits with In vitro Antioxidant and Acetylcholinesterase Inhibitory Activities
임유진, 오창식, 박영두, 김대옥, 김웅진, 조연섭, 엄석현

Five domestic kiwifruit varieties, Bidan (BD),Chiak (CA), Haegeum (HG), Haehyang (HH), and Mansoo(MS), in Korea and two imported varieties, Hayward (HW)and Hort16A (HT), from New Zealand were evaluated mainactive component groups in the fruit extracts involved inantioxidant and anti-dementia activities. HW, HT, and HHexhibited higher soluble solid content. BD, HG, and HHcontained high total phenolics (TP), whereas two importedkiwifruits and green kiwifruits (MS and CA) had low TPcontent. BD show

8
Article|29 citations·2016
Superior Treatment Response and In-field Tumor Control in Epidermal Growth Factor Receptor-mutant Genotype of Stage III Nonsquamous Non–Small cell Lung Cancer Undergoing Definitive Concurrent Chemoradiotherapy
Yu Jin Lim, Ji Hyun Chang, Hak-Jae Kim, Bhumsuk Keam, Tae Min Kim, Dong‐Wan Kim, Jin Chul Paeng, Keon Wook Kang, June-Key Chung, Yoon Kyung Jeon, Doo Hyun Chung, Hong-Gyun Wu
SJR Q1Clinical Lung Cancer
Pulmonary and Respiratory MedicineMedicine
9
Article|23 citations·2020
Risk Stratification Using Neoadjuvant Rectal Score in the Era of Neoadjuvant Chemoradiotherapy: Validation With Long-term Outcome Data
Yu Jin Lim, Changhoon Song, Seung Hyuck Jeon, Kyubo Kim, Eui Kyu Chie
SJR Q2Diseases of the Colon & Rectum

BACKGROUND: Despite the widespread use of neoadjuvant chemoradiotherapy, there is no prognostic surrogate marker established in locally advanced rectal cancer. OBJECTIVE: This study evaluated the role of neoadjuvant rectal score as a prognostic factor to stratify individual-level risks of survival and tumor recurrence. DESIGN: This is a retrospective study. SETTINGS: This study was conducted at the Seoul National University Hospital. PATIENTS: A total of 397 patients who underwent chemoradiother

OncologyMedicine
10
Article|23 citations·2017
Clinical Implications of Cytotoxic T Lymphocyte Antigen-4 Expression on Tumor Cells and Tumor-Infiltrating Lymphocytes in Extrahepatic Bile Duct Cancer Patients Undergoing Surgery Plus Adjuvant Chemoradiotherapy
Yu Jin Lim, Jaemoon Koh, Kyubo Kim, Eui Kyu Chie, Sehui Kim, Kyoung Bun Lee, Jin‐Young Jang, Sun‐Whe Kim, Do‐Youn Oh, Yung‐Jue Bang
SJR Q1Targeted Oncology
SurgeryMedicine
11
Article|23 citations·2017
Failure patterns according to molecular subtype in patients with invasive breast cancer following postoperative adjuvant radiotherapy: long-term outcomes in contemporary clinical practice
Yu Jin Lim, Sea-Won Lee, Noorie Choi, Jeanny Kwon, Keun‐Yong Eom, Eunyoung Kang, Eun‐Kyu Kim, Sung‐Won Kim, Jee Hyun Kim, Yu Jung Kim, Se Hyun Kim, So Yeon Park
SJR Q1Breast Cancer Research and Treatment
Cancer ResearchBiochemistry, Genetics and Molecular Biology
12
Review|23 citations·2019
Adjuvant chemotherapy in rectal cancer patients who achieved a pathological complete response after preoperative chemoradiotherapy: a systematic review and meta-analysis
Yu Jin Lim, Youngkyong Kim, Moonkyoo Kong
SJR Q1Scientific ReportsOA

This study evaluated the prognostic impact of ACT in patients who achieved a pathological complete response (pCR). Articles published from January 1990 to September 2018 were searched in EMBASE, PubMed, Ovid, Web of Science, and Cochrane Library. Hazard ratios (HRs) and 95% confidence intervals (CIs) of overall survival (OS) were extracted. Thirteen observational studies were included. There were four National Cancer Database studies with overlapping study periods, thus individual pooled analyse

OncologyMedicine
13
Article|16 citations·2017
A Novel Prognostic Nomogram for Predicting Risks of Distant Failure in Patients with Invasive Breast Cancer Following Postoperative Adjuvant Radiotherapy
Yu Jin Lim, Sea-Won Lee, Noorie Choi, Jeanny Kwon, Keun‐Yong Eom, Eunyoung Kang, Eun‐Kyu Kim, Jee Hyun Kim, Yu Jung Kim, Se Hyun Kim, So Yeon Park, In Ah Kim
SJR Q1Cancer Research and TreatmentOA

PURPOSE: This study aimed to identify predictors for distant metastatic behavior and build a related prognostic nomogram in breast cancer. MATERIALS AND METHODS: A total of 1,181 patients with non-metastatic breast cancer between 2003 and 2011 were analyzed. To predict the probability of distant metastasis, a nomogram was constructed based on prognostic factors identified using a Cox proportional hazards model. RESULTS: The 7-year overall survival and 5-year post-progression survival of locoregi

Cancer ResearchBiochemistry, Genetics and Molecular Biology
14
Article|13 citations·2015
Tumor Growth Suppression and Enhanced Radioresponse by an Exogenous Epidermal Growth Factor in Mouse Xenograft Models with A431 Cells
Yu Jin Lim, Sang-Rok Jeon, Jae Moon Koh, Hong-Gyun Wu
SJR Q1Cancer Research and TreatmentOA

PURPOSE: The purpose of this study was to evaluate whether an exogenous epidermal growth factor (EGF) could induce anti-tumor and radiosensitizing effects in vivo. MATERIALS AND METHODS: BALB/c-nu mice that were inoculated with A431 (human squamous cell carcinoma) cells in the right hind legs were divided into five groups: I (no treatment), II (EGF for 6 days), III (EGF for 20 days), IV (radiotherapy [RT]), and V (RT plus concomitant EGF). EGF was administered intraperitoneally (5 mg/kg) once a

OncologyMedicine
15
Article|11 citations·2014
Hypofractionated chemoradiotherapy with temozolomide as a treatment option for glioblastoma patients with poor prognostic features
Yu Jin Lim, Il Han Kim, Tae Jin Han, Seung Hong Choi, Sung‐Hye Park, Chul‐Kee Park, Sun Ha Paek, Se‐Hoon Lee, Tae Min Kim
SJR Q1International Journal of Clinical Oncology
GeneticsMedicine

Research Areas

OncologyCancer ResearchNeurologyPulmonary and Respiratory MedicineRadiology, Nuclear Medicine and ImagingOtorhinolaryngology

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