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Yun Dong-hwan

Kyung Hee University · Medicine

About the Lab

Professor Yun Dong-hwan's research lab focuses on musculoskeletal and neurological disorders, with a strong emphasis on balance control in knee osteoarthritis, the neuroprotective mechanisms of natural compounds like naringin in Parkinson’s disease models, and the application of medical imaging and guided interventions in spinal pain management. The lab integrates clinical assessments, cellular assays, and advanced biomechanical analysis to explore pathophysiology and develop targeted therapeutic strategies. Key research directions include postural control, neurodegeneration, and image-guided interventions for spinal and joint disorders.

knee osteoarthritisParkinson’s diseaseultrasonography-guided injectionpostural controlneuroprotection

Research Overview

Papers
96
Total Citations
1,093
Papers (5y)
11
Primary Field
Medicine

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
11total
2021
2022
2023
2025
2026
Citations per year (5y)
73total
20212022202320252026

Selected Papers

15
1
Article|115 citations·2011
Balance Control and Knee Osteoarthritis Severity
Heesang Kim, Dong Hwan Yun, Seung Don Yoo, Dong Hwan Kim, Yong Seol Jeong, Jee-Sang Yun, Dae Gyu Hwang, Pil Kyo Jung, Seong He Choi
SJR Q1Annals of Rehabilitation MedicineOA

OBJECTIVE: To investigate balance control according to the severity of knee osteoarthritis (OA) using clinical tests and Tetra-ataxiometric posturography (Tetrax®). METHOD: A total 80 patients with primary knee OA classified according to American College of Rheumatology criteria, and 40 age-matched controls were enrolled in this study. Of those with OA, 39 patients had mild OA (Kellgren-Lawrence [KL] grade 1, 2) and the other 41 had moderate to severe OA (KL grade 3, 4). The postural control cap

Physical Therapy, Sports Therapy and RehabilitationHealth Professions
2
Article|99 citations·2009
Naringin Protects against Rotenone-induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells
Hak‐Jae Kim, Jeong Yoon Song, Hae‐Jeong Park, Hyun‐Kyung Park, Dong Hwan Yun, Joo‐Ho Chung
SJR Q3Korean Journal of Physiology and PharmacologyOA

Rotenone, a mitochondrial complex I inhibitor, can induce the pathological features of Parkinson's disease (PD). In the present study, naringin, a grapefruit flavonoid, inhibited rotenone-induced cell death in human neuroblastoma SH-SY5Y cells. We assessed cell death and apoptosis by measuring mitogen-activated protein kinase (MAPKs) and caspase (CASPs) activities and by performing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, 4,6-diamidino-2-phenylindole (DAPI) stain

NeurologyMedicine
3
Article|91 citations·2016
The Relationship Between Tongue Pressure and Oral Dysphagia in Stroke Patients
Jong Ha Lee, Hee-Sang Kim, Dong Hwan Yun, Jinmann Chon, Yoo Jin Han, Seung Don Yoo, Dong Hwan Kim, Seung Ah Lee, Hye In Joo, Ji‐Su Park, Jin Chul Kim, Yunsoo Soh
SJR Q1Annals of Rehabilitation MedicineOA

These findings indicate that the tongue pressure appears to be closely related to the oral-phase swallowing function in post-stroke patients, especially BF, mastication, PBL, TP and OTT.

Speech and HearingHealth Professions
4
Article|77 citations·2013
Performance of the Geriatric Nutritional Risk Index in predicting 28-day hospital mortality in older adult patients with sepsis
Jong Seok Lee, Han Sung Choi, Young Gwan Ko, Dong Hwan Yun
SJR Q1Clinical Nutrition
PhysiologyMedicine
5
Article|58 citations·2009
Naringin Protects against Rotenone-induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells
김학재, 송정윤, 박해정, 박현경, 윤동환, 정주호
http://kmbase.medric.or.kr/Main.aspx?d=KMBASE&m=VIEW&i=0811720090130040281

Rotenone, a mitochondrial complex I inhibitor, can induce the pathological features of Parkinson’s disease (PD). In the present study, naringin, a grapefruit flavonoid, inhibited rotenone-induced cell death in human neuroblastoma SH-SY5Y cells. We assessed cell death and apoptosis by measuring mitogen- activated protein kinase (MAPKs) and caspase (CASPs) activities and by performing 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, 4,6-diamidino-2-phenylindole (DAPI) stai

6
Article|51 citations·2012
Efficacy of Ultrasonography-Guided Injections in Patients with Facet Syndrome of the Low Lumbar Spine
Dong Hwan Yun, Heesang Kim, Seung Don Yoo, Dong Hwan Kim, Jinn Man Chon, Seong He Choi, Dae Gyu Hwang, Pil Kyo Jung
SJR Q1Annals of Rehabilitation MedicineOA

OBJECTIVE: To investigate the efficacy of ultrasonography (US)-guided injections in patients with low lumbar facet syndrome, compared with that in patients who received fluoroscopy (FS)-guided injections. METHOD: Fifty-seven subjects with facet syndrome of the lumbar spine of the L4-5 and L5-S1 levels were randomly divided into two groups to receive intraarticular injections into the facet joint. One group received FS-guided facet joint injections and the other group received US-guided facet joi

Pathology and Forensic MedicineMedicine
7
Article|45 citations·2017
Biomechanical Parameters in Plantar Fasciitis Measured by Gait Analysis System With Pressure Sensor
Seung Don Yoo, Hee Sang Kim, Jong Ha Lee, Dong Hwan Yun, Dong Hwan Kim, Jinmann Chon, Seung Ah Lee, Yoo Jin Han, Yunsoo Soh, Yong Kim, Seonyoung Han, Woo-Jin Lee
SJR Q1Annals of Rehabilitation MedicineOA

The researchers show that various biomechanical differences exist between healthy subjects and those with PF. Employing an arch building gait in patients with PF could be helpful in changing gait patterns to normal biomechanics.

Orthopedics and Sports MedicineMedicine
8
Review|40 citations·2022
Therapeutic Effects of Functional Electrical Stimulation on Physical Performance and Muscle Strength in Post-stroke Older Adults: A Review
Hyung Eun Shin, Miji Kim, Daehyun Lee, Jae Young Jang, Yunsoo Soh, Dong Hwan Yun, Sun Young Kim, Jisoo Yang, Maeng Kyu Kim, Hooman Lee, Chang Won Won
SJR Q2Annals of Geriatric Medicine and ResearchOA

Stroke-related disabilities cause poor physical performance, especially among older adults, and can lead to sarcopenia. Functional electrical stimulation (FES) has been used to improve physical performance in individuals with neurological disorders and increase muscle mass and strength to counteract muscle atrophy. This review covers the principles, underlying mechanisms, and therapeutic effects of FES on physical performance and skeletal muscle function in post-stroke older adults. We found tha

RehabilitationMedicine
9
Article|37 citations·2012
Efficacy of Ultrasonography Guided Stellate Ganglion Blockade in the Stroke Patients with Complex Regional Pain Syndrome
Seung Don Yoo, Sang Soo Jung, Heesang Kim, Dong Hwan Yun, Dong Hwan Kim, Jinmann Chon, Dong Whan Hong
SJR Q1Annals of Rehabilitation MedicineOA

OBJECTIVE: To compare the efficacy of ultrasonography guided stellate ganglion block (US-SGB) with that of blind SGB in management of the stroke patients with complex regional pain syndrome (CRPS) type 1. METHOD: Forty-two patients with post-stroke CRPS were randomly assigned to either US-guided SGB (22 patients) or blind SGB group (20 patients). The mean age of US-guided SGB and blind SGB groups was 61.3±5.6 years and 59.1±4.5 years. We performed two blockades at 7-day intervals on the affected

Anesthesiology and Pain MedicineMedicine
10
Article|35 citations·2015
Monomelic Amyotrophy (Hirayama Disease) With Upper Motor Neuron Signs: A Case Report
Seung Don Yoo, Hee-Sang Kim, Dong Hwan Yun, Dong Hwan Kim, Jinmann Chon, Seung Ah Lee, Sung Yong Lee, Yoo Jin Han
SJR Q1Annals of Rehabilitation MedicineOA

Monomelic amyotrophy (MMA), also known as Hirayama disease, is a sporadic juvenile muscular atrophy in the distal upper extremities. This disorder rarely involves proximal upper extremities and presents minimal sensory symptoms with no upper motor neuron (UMN) signs. It is caused by anterior displacement of the posterior dural sac and compression of the cervical cord during neck flexion. An 18-year-old boy visited our clinic with a 5-year history of left upper extremity pain and slowly progressi

SurgeryMedicine
11
Article|27 citations·2011
Association between interleukin 15 receptor, alpha (IL15RA) polymorphism and Korean patients with ossification of the posterior longitudinal ligament
Dong Hwan Kim, Yong Seol Jeong, Jinmann Chon, Seung Don Yoo, Hee-Sang Kim, Sung Wook Kang, Joo‐Ho Chung, Ki-Tack Kim, Dong Hwan Yun
SJR Q1Cytokine
RheumatologyMedicine
12
Article|16 citations·2013
Thoracic Outlet Syndrome Caused by Schwannoma of Brachial Plexus
Dong Hwan Yun, Hee-Sang Kim, Jinmann Chon, Jongeon Lee, Pil Kyo Jung
SJR Q1Annals of Rehabilitation MedicineOA

Schwannomas are benign, usually slow-growing tumors that originate from Schwann cells surrounding peripheral, cranial, or autonomic nerves. The most common form of these tumors is acoustic neuroma. Schwannomas of the brachial plexus are quite rare, and symptomatic schwannomas of the brachial plexus are even rarer. A 47-year-old woman presented with a 1-year history of dysesthesia, neuropathic pain, and mild weakness of the right upper limb. Results of physical examination and electrodiagnostic s

Radiology, Nuclear Medicine and ImagingMedicine
13
Article|13 citations·2014
Association between BH3 interacting domain death agonist (BID) gene polymorphism and ossification of the posterior longitudinal ligament in Korean population
Jinmann Chon, Jang-Hyeok Hong, Jinsung Kim, Yoo Jin Han, Byoung Wook Lee, Soo-Cheol Kim, Dong Hwan Kim, Seung Don Yoo, Hee-Sang Kim, Dong Hwan Yun
SJR Q2Molecular Biology Reports
GeneticsMedicine
14
Article|7 citations·2011
Association between interleukin-4 gene polymorphisms and intracerebral haemorrhage in Korean population
H. J. Park, M. J. Kim, Sung Wook Kang, S. K. Kim, Je Seung Lee, H. K. Park, Seung Don Yoo, D. H. Kim, Dong Hwan Yun, Hoon Sik Kim, J. W. Kim, Joo‐Ho Chung
SJR Q2International Journal of Immunogenetics

Interleukin-4 (IL4) polymorphisms (rs2243250, rs2070874) were analysed in Korean patients with ischaemic stroke (IS) (n=119) and intracerebral haemorrhage (ICH) (n=79), and age-matched controls (n =267, IS; n=401, ICH) using direct sequencing. Both single nucleotide polymorphisms and their haplotypes were associated with ICH, but not IS.

NeurologyMedicine
15
Article|3 citations·2011
Current Status and Evolution Trend of Aquatic Vegetation in Chenghai Lake
Dong Hwan Yun
Plant Diversity and Resources

Aquatic species and population in Chenghai Lake had been dramatically changed in recent two decades. Coverage percentage of aquatic vegetation had varied from a range of 24%-75% to that of 0.2%-85%; and its maximum distribution depth had increased from 4.5m to 5.5m; but the corresponding coverage area had been shrunk from 527.8hm2 to 73.05hm2; the resource storage had reduced from 4766 tons to 314.53 tons. Analysis indicates that destruction of suitable habitat in southern part of the lake, poll

EcologyEnvironmental Science

Research Areas

NeurologySurgeryPhysiologyOrthopedics and Sports MedicineOncologyImmunology

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