Byoung‐In Sang
Hanyang University · 工学
研究室紹介
Professor Byoung-In Sang's research lab specializes in microbial bioproduction of valuable organic acids, particularly medium- and short-chain carboxylic acids such as butyric, caproic, valeric, and heptanoic acids, using anaerobic bacteria. The lab focuses on metabolic engineering, co-culture systems, and process optimization to enhance acid titers and selectivity, with applications in sustainable biofuels and chemical feedstocks. Key research directions include strain isolation, electron transfer manipulation via mediators or electrochemical systems, and overcoming product toxicity through tailored fermentation strategies.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15In this paper, the different applications of butyric acid and its current and future production status are highlighted, with a particular emphasis on the biofuels industry. As such, this paper discusses different issues regarding butyric acid fermentations and provides suggestions for future improvements and their approaches.
Butanol production by Clostridium beijerinckii NCIMB 8052 was investigated using both batch and continuous cultures containing suspended or immobilized cells. In the batch reactor, the initial addition of acetate and butyrate into the culture media was found not only to enhance solvent production but also to affect the ratio of acetone/butanol, which might result from the metabolic changes in solvent production. Furthermore, the addition of butyrate to the medium prevented strain degeneration du
Electron mediators and electron supply through a cathode were examined to enhance the reducing power for butyrate production by an acidogenic clostridium strain, Clostridium tyrobutyricum BAS 7. Among the tested electron mediators, methyl viologen (MV)-amended cultures showed an increase of butyrate productivity (1.3 times), final concentration (1.4 times), and yield (1.3 times). The electron flow altered by MV addition from the ferredoxin pool to the NADH pool was shown by one electron model, i
BACKGROUND: C5-C8 medium-chain carboxylic acids are valuable chemicals as the precursors of various chemicals and transport fuels. However, only a few strict anaerobes have been discovered to produce them and their production is limited to low concentrations because of product toxicity. Therefore, a bacterial strain capable of producing high-titer C5-C8 carboxylic acids was strategically isolated and characterized for production of medium chain length carboxylic acids. RESULTS: Hexanoic acid-pro
Abstract The caproate-producing bacterium, Megasphaera hexanoica , metabolizes fructose to produce C 2 ~C 8 carbon-chain carboxylic acids using various electron acceptors. In particular, odd-chain carboxylic acids (OCCAs) such as valerate (C 5 ) and heptanoate (C 7 ), were produced at relatively high concentrations upon propionate supplementation. Using a statistical experimental design method, the optimal culture medium was established for the selective production of OCCAs among the total produ