Chan-hyung Kim
Yonsei University · 心理学
研究室紹介
Professor Chan-hyung Kim's research lab focuses on translational biomedical research, particularly in cardiovascular disease mechanisms and neuropsychiatric disorders. The lab investigates molecular pathways underlying cardiac protection, such as the role of HIF-1 and Akt signaling in ischemic preconditioning and mechanical stress-induced angiogenesis. It also explores the neurobiological and psychological underpinnings of psychiatric conditions, including obsessive-compulsive disorder and bipolar disorder, with a focus on symptom subtypes, comorbidities like alexithymia, and treatment algorithms. Additionally, the lab examines non-pharmacological interventions, such as aerobic exercise, in improving mental and physical health outcomes in schizophrenia and other chronic mental illnesses.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Vascular endothelial growth factor (VEGF) expression is upregulated by hypoxia-inducible factor-1 (HIF-1) in ischemic tissues and growing tumors. Normally, HIF-1 activity depends on the amount of HIF-1alpha subunit, which is tightly regulated by the oxygen tension. In the myocardium, VEGF expression has been shown to be induced under nonhypoxic conditions by mechanical stresses. However, the cellular mechanism of stress-mediated VEGF induction remains unclear. Therefore, we examined the possible
Previous studies have indicated that obsessive-compulsive disorder (OCD) is associated with alexithymic traits. The purpose of the current study was to evaluate the difference of alexithymia in OCD patients and healthy controls. This study was also designed to elucidate a specific link between certain OCD symptom dimensions and alexithymia. Forty-five patients with OCD and 45 healthy controls completed measures of the OCD symptom severity, alexithymia, anxiety, and depression. Patients with OCD
Obsessive-compulsive disorder (OCD) is a clinically heterogeneous disorder; nonetheless, most of the previous neuropsychological studies for assessing the involvement of memory dysfunction grouped together patients with different symptoms, thereby potentially accounting for the inconsistencies of results. The goals of this study were to compare the memory dysfunction of two main subtypes of OCD and to identify the type of memory dysfunction that is associated with the checking symptoms in OCD pa
The objective of this study was to examine the feasibility and sustained effect of a group aerobic exercise program in patients with schizophrenia. Twenty-four schizophrenic patients participated in a group-based individually tailored 90-minute outdoor cycling session per week for 3 months with intervention to enhance motivation. Physical health was evaluated by anthropometric measures, cardiorespiratory (CR) fitness, and blood tests. Mental health was assessed on self-esteem, interpersonal rela
목 적：양극성 장애의 치료에 있어서 임상의의 적절한 결정을 돕기 위해 개발된 한국형 약물치료 알고리듬의 적용 가능성을 평가하고자 알고리듬을 임상 상황에 사용하였다. 본 연구는 알고리듬을 적용한 경우, 실제 임상에서의 적용 가능성에 대한 전반적 평가를 위해 시행되었다. 방 법：연구대상의 포함기준은 DSM-IV에 의거한 18세 이상의 양극성 장애 환자였다. 원칙적으로 약물의 선택, 교체, 단계의 이동 등은 알고리듬에서 추천하는 방법을 따르도록 했으나 연구자의 판단에 의해 언제라도 바꿀 수 있었다. 치료반응의 평가는 YMRS, HAM-D, CGI, GAF를 이용하였고 내약성은 LUNSERS와 UKU로 평가하였다. 각 단계에서 약물치료 2주 째에 무반응이거나 4주 째에 부분 반응이면 다음 치료단계로 넘어갈 수 있었다. 모든 환자들은 치료 4개월 시점에 최종 평가를 받도록 하였다. 결 과：본 연구에는 17개 기관에서 18명의 연구자가 참여하였으며, 총 126명의 양극성 장애 환자가 등록되어
Akt/protein kinase B is a well-known cell survival factor and activated by many stimuli including mechanical stretching. Therefore, we evaluated the cardioprotective effect of a brief mechanical stretching of rat hearts and determined whether activation of Akt through phosphatidylinositol 3-kinase(PI3K) is involved in stretch-induced cardioprotection (SIC). Stretch preconditioning reduced infarct size and improved postischemic cardiac function compared to the control group. Phosphorylation of Ak
가상현실은 최근 10여 년간의 비약적 발전을 통해 정신의학의 여러 분야에서 진단 및 치료를 위한 도구로서 인정 받고 있다. 지금까지 진행된 연구 분야는 불안 장애, 정신분열병, 소아 정신 질환, 치매, 물질 의존 장애, 신경심리 평가 및 인지기능 연구 등이다. 정보화라는 시대적 변화에 따라 가상현실 관련 기술은 빠르게 발전, 보편화되고 있으며 필요한 장비의 가격은 급락하고 있다. 따라서 가상현실을 이용한 연구의 걸림돌이 되었던 기술 및 비용의 도입 장벽은 점점 낮아지고 있다. 이 시점에 정신의학적 측면에서 가상현실을 이해하고 현실적으로 적용하기 위하여 저자들은 기존 연구의 고찰을 통해 올바른 발전 방향을 제시하고자 했다.