Dong-Seok Kim
Yonsei University · 医学
研究室紹介
Professor Dong-Seok Kim's research lab focuses on cellular signaling pathways and molecular mechanisms underlying skin pigmentation, neurodegenerative diseases, and cancer cell death. The lab investigates bioactive lipid mediators like sphingosine-1-phosphate and small molecules such as 4-n-butylresorcinol and novel compounds like KHG22394 to modulate melanogenesis through key signaling pathways including ERK and Akt. It also explores the role of oxidative stress and reactive oxygen species in apoptosis, particularly in melanoma cells, and examines cytoskeletal proteins like septins in cancer cell division. The lab’s work bridges dermatology, neuroscience, and cancer biology with translational applications in skin whitening agents and neuroprotective therapeutics.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Sphingosine-1-phosphate (S1P) has emerged as a bioactive lipid modulator that mediates a variety of cell functions. However, the effects of S1P on melanogenesis are not well known. Therefore, we investigated the actions of S1P on melanin synthesis using a spontaneously immortalized mouse melanocyte cell line, Mel-Ab. This study shows that S1P significantly inhibits melanin synthesis in a concentration-dependent manner, and also that the activity of tyrosinase was reduced in S1P-treated cells. In
During our on-going attempts to develop a new skin-whitening agent, we identified a novel candidate compound KHG22394, a 2-imino-1,3-thiazoline derivative. Our data show that KHG22394 significantly inhibits melanin production in a dose-dependent manner, but that it does not directly inhibit tyrosinase, the rate limiting melanogenic enzyme. It has been reported that the activation of extracellular signal-regulated kinase (ERK) reduces melanin synthesis by downregulating microphthalmia-associated
OBJECTIVES: The unfavorable surgical results that have been reported with insular epilepsy surgery may be related to inadequate monitoring. Insular epilepsy surgery requires the precise monitoring and tailored removal of the epileptic zone. The purposes of this study were to precisely monitor the hidden cortex and determine the effectiveness of using different monitoring methods, including subpial depth electrodes. MATERIALS AND METHODS: This is a study of a single center series of six patients