Geun-soo Kim
Yonsei University · 医学
研究室紹介
Professor Geun-soo Kim's research lab specializes in spinal degeneration and spinal surgery, with a focus on intervertebral disc biology, disc degeneration models, and spinal implant technologies. The lab investigates the biological mechanisms underlying disc degeneration, including the effects of nicotine on disc cell metabolism and extracellular matrix regulation, as well as the clinical outcomes of spinal instrumentation and arthroplasty. Research also extends to surgical strategies for spinal fusion and the management of spinal disorders during pregnancy, emphasizing both experimental models and clinical applications. The lab integrates molecular biology, surgical techniques, and long-term clinical follow-up to advance spinal health and surgical outcomes.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15In the first experiment, the 21-gauge 3-puncture and the 18-gauge 1-puncture models produced the most consistent disc degeneration in the rabbit lumbar spine. When these 2 models were again studied in the second experiment, the 21-gauge 3-puncture technique was superior in producing disc degeneration over a shorter period of time.
In most spinal diseases, including HLD and tumors, prepartum surgical treatment can be safely performed maintaining pregnancy. For patients with progressive neurologic deficit at 34 to 36 weeks gestation or later, spine surgery should be performed following the induction of delivery or a cesarean section, or at the same time.
OBJECT: Systemic nicotine has been hypothesized to cause degeneration of the intervertebral disc which in turn decreases vascular supply to the disc through a cholinergic receptor-mediated process. Another possible mechanism may be through direct regulatory effects on disc cells. In this study, the authors tested the hypothesis that nicotine adversely affects nucleus pulposus cells by directly inhibiting proteoglycan synthesis and gene expression of type II collagen (Phase I study). They also as
STUDY DESIGN: Prospective clinical study. OBJECTIVE: To evaluate the factors that would predispose a patient to heterotopic ossification (HO) formation after cervical arthroplasty. SUMMARY OF BACKGROUND DATA: HO after arthroplasty is one of the complications of cervical total disk replacement (TDR). However, the predisposing factors and pathophysiology of HO have not been precisely described. MATERIALS AND METHODS: We prospectively enrolled and followed up 23 patients, who received single-level
All the intervertebral bone fusion after PLIF occurred inside the cages and in the posterior intervertebral space. We suggest the complete removal of discmaterial and deep insertion of the cages to create sufficient posterior intervertebral space for bone growth. PLIF using cages impacted with laminar bone chips is a useful method when considering the time required for surgery and the morbidity of the autograft donor sites.
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We report a significant improvement of an approximate method of including electron Coulomb distortion in electron-induced reactions at momentum transfers greater than the inverse of the size of the target nucleus. In particular, we have found a new parametrization for the elastic electron scattering phase shifts that works well at all electron energies greater than 300 MeV. As an illustration, we apply the improved approximation to the ${(e,e}^{\ensuremath{'}}p)$ reaction from medium and heavy n
STUDY DESIGN: Retrospective case analysis. OBJECTIVE: This study was conducted to investigate the course of ossification of the posterior longitudinal ligament (OPLL) progression after laminoplasty (LP) or laminectomy with posterior fixation (PF). SUMMARY OF BACKGROUND DATA: LP is now recognized as a standard technique for the treatment of cervical multisegment OPLL; however, PF is beneficial for patients with severe stenosis. In recent years, there has been increasing interest in mechanical str
OBJECTIVE: Orbotron training is a popular training method for fighter pilots because it replicates a high-acceleration environment with excessive G-force. The purpose of this study was to investigate the effects of 9 weeks of orbotron training on oxidative DNA damage and antioxidant capacity in humans during 3-dimensional space exercise. SUBJECTS AND METHODS: The subjects comprised 15 senior cadets from the Korea Air Force Academy who had no record of medical disorders and who participated in a
BACKGROUND: Many patients with cervical radiculopathy experience stenosis of the neural foramens due to cumulative osteophyte or uncovertebral joint hypertrophy. For cervical foraminal stenosis, complete uncinate process resection (UPR) is often conducted concurrently with anterior discectomy and fusion (ACDF). The aim of this study was to assess the clinical and radiological outcomes of ACDF with complete UPR versus ACDF without UPR. METHODS: In total, 105 patients who performed one-level ACDF