Hak Jae Kim
Seoul National University · 医学
研究室紹介
Professor Hak Jae Kim's research lab specializes in radiation oncology and translational cancer research, with a strong focus on optimizing radiotherapy outcomes in sarcomas, esophageal cancer, and uterine cervical cancer. The lab investigates adjuvant radiotherapy efficacy, treatment response patterns, and prognostic factors to improve survival and reduce complications. It also explores novel epigenetic agents like psammaplin A, examining their pharmacokinetics and tissue distribution to support the development of targeted cancer therapies. The lab integrates clinical data with preclinical pharmacological studies to advance personalized radiation treatment strategies.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15OBJECTIVES: To analyze the treatment outcomes and the effects of adjuvant radiotherapy (RT) in patients with synovial sarcoma (SS). MATERIALS AND METHODS: The medical records of 103 patients treated with definitive surgery for SS, with/without RT, from August 1982 to July 2013 were reviewed retrospectively. The median age of the patients was 33 years (range, 5 to 72 y). The most frequent tumor location was the extremities (79 patients, 77%). Seventy-five patients (73%) received adjuvant RT and 2
AIMS AND BACKGROUND: To evaluate whether doses or dose rates at International Commission on Radiation Units (ICRU) reference points are of value for predicting risks of late rectal and bladder morbidity in patients with uterine cervical cancer who have undergone external beam radiotherapy and intracavitary irradiation. METHODS: Late rectal complications and late bladder complications were evaluated in 54 patients who were treated by external beam radiotherapy followed by intracavitary irradiatio
This study reports the pharmacokinetics and tissue distribution of a novel histone deacetylase and DNA methyltransferase inhibitor, psammaplin A (PsA), in mice. PsA concentrations were determined by a validated LC-MS/MS assay method (LLOQ 2 ng/mL). Following intravenous injection at a dose of 10 mg/kg in mice, PsA was rapidly eliminated, with the average half-life (t1/2, λn) of 9.9 ± 1.4 min and the systemic clearance (CLs) of 925.1 ± 570.1 mL/min. The in vitro stability of PsA was determined in
BACKGROUND: To analyze treatment outcomes and patterns of recurrence, and to examine the impact of adjuvant postoperative radiotherapy (PORT) after esophagectomy in esophageal squamous cell carcinoma (SqCC) regarding the status of circumferential resection margin (CRM). PATIENTS AND METHODS: We performed a retrospective review of esophageal cancer patients operated in Seoul National University Hospital between 2003 and 2010. Pathologically proven T3 SqCC patients with written reports mentioning
유럽에서는 냉전기간 동안 상대적인 평화를 유지했지만 동아시아에서는 한국전쟁과 대만해협분쟁 베트남전 등의 열전과 군사적 갈등이 빈번하게 발생했다. 이 글은 이렇게 유럽과 동아시아에서 지역냉전이 다르게 전개된 원인과 역사적 발전경로를 추적하기 위해 역사제도주의의 사전조건, 균열구조, 결정적 국면, 초기 포섭양식, 유산의 지속과 차별적 대응이라는 개념적 분석틀을 적용했다. 분석결과 먼저 유럽과 동아시아는 냉전의 사전조건부터 달랐다. 유럽에선 오랜 기간 국민국가 체제가 자리잡은 상태에서 독일문제를 다자주의적으로 처리하려 했지만, 동아시아는 식민지배에서 벗어나 새로운 독립국가를 수립하는 것이 가장 큰 당면 과제였다. 둘째, 유럽과 동아시아는 냉전 균열구조의 형성과 결정적 국면의 양상이 달랐다. 유럽의 냉전과 분단은 1949년부터 1955년경까지 느리고 약하게 진행되었지만, 동아시아에서는 1948년에 분단정부가 수립되고 1950년엔 지역차원의 전면전인 한국전쟁이 발발했다. 유럽은 미소 냉전 균
BACKGROUND: The purpose of this study was to compare the treatment efficacy and safety of re-irradiation (re-RT) using stereotactic ablative radiotherapy (SABR) and initial SABR for primary, recurrent lung cancer or metastatic lung tumor. METHODS: A retrospective review of the medical records of 336 patients who underwent lung SABR was performed. Re-RT was defined as the overlap of the 70% isodose line of second-course SABR with that of the initial radiotherapy, and 20 patients were classified a