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Hee-Pyoung Park

Seoul National University · 医学

研究室紹介

Professor Hee-Pyoung Park's research lab specializes in critical care medicine and anesthesiology, with a focus on improving perioperative outcomes through innovative pharmacological and physiological interventions. Key research directions include optimizing intensive care unit (ICU) patient management using predictive scoring systems like APACHE II, mitigating postoperative complications such as catheter-related bladder discomfort, and exploring neuroprotective strategies in cerebral ischemia using anesthetic agents like sevoflurane and dexmedetomidine. The lab also investigates hemodynamic and microcirculatory responses during surgical procedures, particularly in relation to oxygenation, positioning effects on intraocular pressure, and thrombolytic therapy enhancement with albumin.

critical careanesthesianeuroprotectionmicrocirculationICU outcomes

Research Overview

Papers
237
Total Citations
3,344
Papers (5y)
41
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
41total
2022
2023
2024
2025
2026
Citations per year (5y)
193total
20222023202420252026

Selected Papers

15
1
Article|116 citations·2015
Efficacy of the APACHE II Score at ICU Discharge in Predicting Post-ICU Mortality and ICU Readmission in Critically Ill Surgical Patients
H. Lee, Cheong Lim, Hyunsook Hong, Jae‐Woo Ju, Young‐Tae Jeon, Jung‐Won Hwang, Hee‐Pyoung Park
SJR Q2Anaesthesia and Intensive CareOA

In this study, we evaluated the efficacy of the discharge Acute Physiology and Chronic Health Evaluation (APACHE) II score in predicting post-intensive care unit (ICU) mortality and ICU readmission during the same hospitalisation in a surgical ICU. Of 1190 patients who were admitted to the ICU and stayed >48 hours between October 2007 and March 2010, 23 (1.9%) died and 86 (7.2%) were readmitted after initial ICU discharge, with 26 (3.0%) admitted within 48 hours. The area under the receiver oper

EpidemiologyMedicine
2
Article|86 citations·2017
Dexmedetomidine confers neuroprotection against transient global cerebral ischemia/reperfusion injury in rats by inhibiting inflammation through inactivation of the TLR-4/NF-κB pathway
Eugene Kim, Hyun‐Chang Kim, Seungmi Lee, Ho Geol Ryu, Yong‐Hee Park, Jun Hyun Kim, Young‐Jin Lim, Hee‐Pyoung Park
SJR Q2Neuroscience LettersOA
NeurologyNeuroscience
3
Article|71 citations·2014
The effect of intraoperative dexmedetomidine on postoperative catheter-related bladder discomfort in patients undergoing transurethral bladder tumour resection
Hyun‐Chang Kim, Yong‐Hun Lee, Young-Tae Jeon, Jung‐Won Hwang, Young‐Jin Lim, Jung-Eun Park, Hee‐Pyoung Park
SJR Q1European Journal of AnaesthesiologyOA

BACKGROUND: Catheter-related bladder discomfort (CRBD) due to an indwelling urinary catheter causes postoperative distress. Dexmedetomidine is used as an anaesthetic adjuvant during general anaesthesia and has an antimuscarinic effect, which may be beneficial for the prevention and treatment of CRBD. OBJECTIVE: To determine the effect of intraoperative dexmedetomidine administration on the incidence of CRBD. DESIGN: A double-blind, placebo-controlled, randomised study. SETTING: A tertiary care t

UrologyMedicine
4
Article|52 citations·2018
Predictive Factors for Delayed Hyponatremia After Endoscopic Transsphenoidal Surgery in Patients with Nonfunctioning Pituitary Tumors: A Retrospective Observational Study
Hyun‐Kyu Yoon, Hyung‐Chul Lee, Yong Hwy Kim, Young‐Jin Lim, Hee‐Pyoung Park
SJR Q2World Neurosurgery
Endocrinology, Diabetes and MetabolismMedicine
5
Article|43 citations·2017
Sevoflurane Postconditioning-Induced Anti-Inflammation via Inhibition of the Toll-Like Receptor-4/Nuclear Factor Kappa B Pathway Contributes to Neuroprotection against Transient Global Cerebral Ischemia in Rats
Jung‐Won Hwang, Young-Tae Jeon, Young‐Jin Lim, Hee‐Pyoung Park
SJR Q1International Journal of Molecular SciencesOA

The anti-inflammatory actions of sevoflurane postconditioning are suggested as an important mechanism of sevoflurane postconditioning-induced neuroprotection against cerebral ischemia. Here, we determined whether the anti-inflammatory effects of sevoflurane postconditioning were mediated via inhibition of the toll-like receptor (TLR)-4/nuclear factor kappa B (NF-κB) pathway after global transient cerebral ischemia in rats. Forty-five rats were randomly assigned to five groups as follows: (1) con

Developmental NeuroscienceNeuroscience
6
Article|42 citations·2012
Predictive factors of symptomatic cerebral hyperperfusion after superficial temporal artery-middle cerebral artery anastomosis in adult patients with moyamoya disease
Jung‐Won Hwang, H M Yang, Hyon Lee, H. K. Lee, Young-Tae Jeon, Jeong Eun Kim, Young‐Jin Lim, Hee‐Pyoung Park
SJR Q1British Journal of AnaesthesiaOA
RheumatologyMedicine
7
Article|41 citations·2011
A preemptive alveolar recruitment strategy before one-lung ventilation improves arterial oxygenation in patients undergoing thoracic surgery: a prospective randomised study
Sangheon Park, Young-Tae Jeon, Jung‐Won Hwang, Sang-Hwan Do, Ju Hee Kim, Hee‐Pyoung Park
SJR Q1European Journal of Anaesthesiology

Preemptive ARS before OLV is effective in improving arterial oxygenation during the entire period of OLV.

Pulmonary and Respiratory MedicineMedicine
8
Article|39 citations·2006
The effect of the lateral decubitus position on the intraocular pressure in anesthetized patients undergoing lung surgery
J.‐W. Hwang, Y.‐T. Jeon, J.‐H. Kim, Yoon‐Sang Oh, Hee‐Pyoung Park
SJR Q2Acta Anaesthesiologica Scandinavica

BACKGROUND: Changing the body position alters the intraocular pressure (IOP). The aim of this study was to investigate the alteration in IOP of the eyes after a positional change from a supine position to a lateral decubitus position in anesthetized patients, in order to detect differences in IOP between the two eyes, possibly due to a gravity effect, in the lateral decubitus position. METHODS: IOP was measured in 20 patients undergoing lung surgery. IOP in both eyes was recorded prior to anesth

SurgeryMedicine
9
Article|39 citations·2014
Sevoflurane post-conditioning increases nuclear factor erythroid 2-related factor and haemoxygenase-1 expression via protein kinase C pathway in a rat model of transient global cerebral ischaemia
H. Lee, Y.H. Park, Young-Tae Jeon, Jung‐Won Hwang, Young‐Jin Lim, Eun‐Hye Kim, S.Y. Park, Hee‐Pyoung Park
SJR Q1British Journal of Anaesthesia
Developmental NeuroscienceNeuroscience
10
Article|35 citations·2016
The effect of sevoflurane versus desflurane on postoperative catheter-related bladder discomfort in patients undergoing transurethral excision of a bladder tumour: a randomized controlled trial
Hyun‐Chang Kim, Won‐Pyo Hong, Young‐Jin Lim, Hee‐Pyoung Park
SJR Q1Canadian Journal of Anesthesia/Journal canadien d anesthésieOA
Psychiatry and Mental healthMedicine
11
Article|34 citations·2008
Albumin Therapy Augments the Effect of Thrombolysis on Local Vascular Dynamics in a Rat Model of Arteriolar Thrombosis
Hee‐Pyoung Park, Anitha Nimmagadda, R. Anthony DeFazio, Raul Busto, Ricardo Prado, Myron D. Ginsberg
SJR Q1StrokeOA

BACKGROUND AND PURPOSE: Results of our recent pilot clinical trial suggest that the efficacy of thrombolytic therapy in acute ischemic stroke may be enhanced by the coadministration of high-dose albumin. Here, we explored the microvascular hemodynamic effects of this combined therapy in a laboratory model of cortical arteriolar thrombosis. METHODS: We studied the cortical microcirculation of physiologically monitored rats in vivo by two-photon laser-scanning microscopy after plasma-labeling with

EpidemiologyMedicine
12
Article|33 citations·2005
Isoflurane preconditioning protects motor neurons from spinal cord ischemia: Its dose–response effects and activation of mitochondrial adenosine triphosphate-dependent potassium channel
Hee‐Pyoung Park, Young-Tae Jeon, Jung‐Won Hwang, Hoon Kang, Seung-Woon Lim, Chong-Sung Kim, Yong‐Seok Oh
SJR Q2Neuroscience Letters
Pathology and Forensic MedicineMedicine
13
Article|32 citations·2020
Randomized crossover trial comparing cervical spine motion during tracheal intubation with a Macintosh laryngoscope versus a C-MAC D-blade videolaryngoscope in a simulated immobilized cervical spine
Hyesun Paik, Hee‐Pyoung Park
SJR Q1BMC AnesthesiologyOA

BACKGROUND: Maintaining cervical immobilization is essential during tracheal intubation in patients with unstable cervical spines. When using the Macintosh laryngoscope for intubation in patients with cervical immobilization, substantial neck extension is required for visualization of the glottis. However, the C-MAC D-Blade videolaryngoscope may require less neck extension due to its acute angulation. We hypothesized that C-MAC D-Blade videolaryngoscopic intubation would result in less cervical

Anesthesiology and Pain MedicineMedicine
15
Article|30 citations·2017
Radiographic Predictors of Difficult Laryngoscopy in Acromegaly Patients
Hyung‐Chul Lee, Min-Kyung Kim, Yong Hwy Kim, Hee‐Pyoung Park
SJR Q2Journal of Neurosurgical Anesthesiology

BACKGROUND: Patients with acromegaly have a high risk of difficult laryngoscopy. However, clinical predictors, such as upper lip bite test or modified Mallampati class, show limited predictive performance for difficult laryngoscopy in such patients. In this retrospective study, we evaluated radiographic indices obtained from skull lateral x-ray and ostiomeatal unit computed tomography images to predict difficult laryngoscopy in acromegaly patients. MATERIALS AND METHODS: Data on demographics, pr

Endocrinology, Diabetes and MetabolismMedicine

Research Areas

Anesthesiology and Pain MedicineSurgeryNeurologyEmergency Medical ServicesPulmonary and Respiratory MedicineEndocrinology, Diabetes and Metabolism

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