Hyeon-Joo Lee

The glymphatic pathway expedites clearance of waste, including soluble amyloid β (Aβ) from the brain. Transport through this pathway is controlled by the brain's arousal level because, during sleep or anesthesia, the brain's interstitial space volume expands (compared with wakefulness), resulting in faster waste removal. Humans, as well as animals, exhibit different body postures during sleep, which may also affect waste removal. Therefore, not only the level of consciousness, but also body post

Many studies have documented that ginseng has antidiabetic and antiobesity effects, but the mechanism of the effects has not been elucidated. The aim of this study was to determine the effect of Korean red ginseng (KRG, Panax ginseng) and investigate the mechanism of antidiabetic and antiobesity effects in obese insulin resistant animal models. Sprague-Dawley (SD) rats were divided into three groups: a control group (group I) fed a normal diet, another group (group II) fed only high fat diet (HF

Background The adoption of immersive technology in simulation-based nursing education has grown significantly, offering a solution to resource limitations and enabling safe access to clinical environments. Despite its advantages, there are still diverse reports regarding the effectiveness of immersive technology. It is crucial to verify the effectiveness of immersive technology in nursing education to inform future educational programs. Objective This systematic review aimed to identify the cont

Chronic inflammation is fundamental for the induction of insulin resistance in the muscle tissue of vertebrates. Although several miRNAs are thought to be involved in the development of insulin resistance, the role of miRNAs in the association between inflammation and insulin resistance in muscle tissue is poorly understood. Herein, we investigated the aberrant expression of miRNAs by conducting miRNA microarray analysis of TNF-α-treated mouse C2C12 myotubes. We identified two miRNAs that were u

Hepatitis B virus (HBV) infection is associated with a broad spectrum of clinical manifestations, including cirrhosis and hepatocellular carcinoma (HCC). Endoplasmic reticulum (ER) stress and subsequent oxidative stress have been implicated in liver carcinogenesis and disease progression with chronic inflammation. In our previous study, several mutations in the precore/core region of HBV genotype C were identified from 70 Korean chronic patients, and the mutations were associated with HCC and/or

Achillea alpina is widely distributed in Korea and is often used as a folk medicine for stomach disorders. Although a previous study isolated antioxidant compounds (flavonoid O-glucoside, sesquiterpene) from this plant, no systematic study of its chemical constituents had been reported. The present study aimed to identify the phytochemicals present in a methanol extract of A. alpina, assess their potential antioxidant activities in vitro, and determine their effects on melanogenesis in B16F10 me

α-Hydroxy alkylphosphonates have received attention both as substrates for the preparation of other α-substituted phosphonates, 1 and because of their inhibitory activity towards several important groups of enzymes, including farnesyl protein transferase, renin, HIV protease, and 5-enolpyruvylshikimate-3-phosphate synthase, and various classes of protein tyrosine kinases and phosphatases. 2 Although certainly some are known, 3 examples where the a carbon is fully substituted are less common and

본 연구는 치매노인의 특성과 가족부양자의 특성이 부양부담에 미치는 영향을 살펴보는 것을 목적으로 하였다. 특히 치매의 주요 증상인 인지기능과 일상생활기능장애가 부양부담에 미치는 영향이 사회적 지지에 따라 어떻게 달라지는지 살펴보는 것에 초점을 두었다. 분석자료는 병원과 치매지원센터를 내원하는 치매환자의 가족부양자 가운데 일주일에 3일 이상 치매환자를 부양하는 사람 213명을 대상으로 하였다. 분석방법은 치매노인의 인지기능 및 일상생활기능장애와 사회적 지지의 상호작용항을 위계적으로 투입하는 다중회귀분석을 실시하여 조절효과를 검증하였다. 본 연구의 주요 결과는 다음과 같다. 첫째, 치매노인 관련특성 가운데 치매의 주요 증상인 인지기능손상과 일상생활기능장애는 모두 가족부양자의 부양부담을 높이는 것으로 나타났다. 인구사회학적 특성 가운데에는 치매노인의 연령이 많고, 교육수준이 높을수록 부양부담이 높았다. 둘째, 가족부양자 관련 특성에서 부양자의 연령이 높을수록, 그리고 직업이 있는 경우 부