Hyun Ju Lee

In Brief Study Design. Validation of a translated, culturally adapted questionnaire. Objectives. To translate and culturally adapt a Korean version of the Oswestry Disability Index (ODI) and to validate its use in Korean patients. Summary of Background Data. The ODI is one of the most widely used and validated instruments for measuring disability in spinal disorders. However, no validated Korean version of the index was available at the time our study was initiated. Methods. The study was carrie

Mycoplasma pneumoniae is an important cause of community-acquired pneumonia in children and young adolescents. Macrolides are recommended as the first-line therapy however, macrolide resistance rates in M. pneumoniae among children have been increasing substantially. Areas covered: This review focused on clinical characteristics and treatment of macrolide-resistant M. pneumoniae pneumonia in children. Expert commentary: Antibiotic choice should be based on in vitro activity, clinical efficacy an

BACKGROUND: Coronavirus disease 2019 (COVID-19) was introduced in Korea early with a large outbreak in mid-February. We reviewed the public health interventions used during the COVID-19 outbreak and describe the impact on seasonal influenza activity in Korea. METHODS: National response strategies, public health interventions and daily COVID-19-confirmed cases in Korea were reviewed during the pandemic. National influenza surveillance data were compared between 7 sequential seasons. Characteristi

본 연구는 노인우울증에 대한 사회경제적 지위의 영향력 뿐 아니라 근접요인으로써 건강행태의 영향력을 파악하여 보다 실천적인 함의를 제시하고자 하였다. 이를 위해 일 도시지역의 65세 이상 노인 964명의 자료를 분석에 사용하였고, 노인우울증 진단에는 단축형 노인우울척도(Short Form of Geriatric Depression Scale: SGDS)의 절단점 10점을 사용하였다. 본 연구에서 노인우울증의 유병율(SGDS≥10)은 22.2%(남성 18.4%, 여성 23.3%)로 나타났다. 로지스틱 회귀분석을 사용하여 노인우울증에 대한 위험요인을 살펴본 결과, 동거가족 수가 적을수록, 의료보호일수록, 교육수준이 낮을수록, 흡연을 지속하고 있을수록, 신체활동이 불충분할수록 노인우울증의 유병율이 유의미하게 높아지는 것으로 나타났다. 본 연구의 결과를 바탕으로 볼 때 사회경제적 차이를 고려하여 노인우울증 개입을 위한 표적집단을 정해야 하고 더불어 우울증 예방을 위해서는 건강행태 특히 흡연이

Fluorodeoxyglucose (FDG)-positron emission tomography (PET) is being used more and more to differentiate benign from malignant focal lesions and it has been shown to be more efficacious than conventional chest computed tomography (CT). However, FDG is not a cancer-specific agent, and false positive findings in benign diseases have been reported. Infectious diseases (mycobacterial, fungal, bacterial infection), sarcoidosis, radiation pneumonitis and post-operative surgical conditions have shown i

The currently available 7-valent pneumococcal conjugate vaccine (PCV7) elicits good immune response to and is effective against vaccine serotypes. However, its effectiveness against vaccine-related serotypes is variable. Serum samples were obtained 1 month after the last vaccination from 31 infants immunized with PCV7 at 2, 4, and 6 months of age. The sera were used to determine immunoglobulin G antibody levels to eight serotypes (seven vaccine serotypes and serotype 19A) with enzyme-linked immu

To evaluate the inter-group differences in growth and the pathological results of nodular ground-glass opacities (GGOs) according to their size and focal solid portions. Materials and Methods: Ninety-six nodular GGOs in 55 individuals followed by CT for at least one month from an initial chest CT were included. Forty nodular GGOs in 30 individuals were pathologically confirmed to be: adenocarcinoma (n = 15), bronchioloalveolar carcinoma (BAC) (n = 11), atypical adenomatous hyperplasia (AAH) (n =

In areas with high prevalence of macrolide-resistant Mycoplasma pneumoniae (MRMP) pneumonia, treatment in children has become challenging. This study aimed to analyze the efficacy of macrolides and doxycycline with regard to the presence of macrolide resistance. We analyzed children with MP pneumonia during the two recent epidemics of 2014–2015 and 2019–2020 from four hospitals in Korea. Nasopharyngeal samples were obtained from children with pneumonia for MP cultures and polymerase chain reacti

This study aimed to assess the immune status of the Korean population against hepatitis A virus (HAV). Residual serum samples from 2008 to 2010 were collected from diagnostic laboratories and a total of 1,872 samples were analyzed. Anti-HAV seroprevalence was 57.3% in subjects aged 1-4 yr, 69.8% at 5-9 yr and decreased to 38.8% at 10-14 yr, 13.0% at 15-19 yr, and 11.7% at 20-29 yr. Seroprevalence increased with increasing age: 52.2% at 30-39 yr, 83.2% at 40-49 yr, 81.4% at 50-59 yr, 93.2% at 60-

BACKGROUND: Streptococcus pneumoniae is a leading cause of morbidity and mortality in the elderly. To prevent invasive pneumococcal diseases, the 23-valent pneumococcal polysaccharide vaccine (PPV) is recommended in subjects over 65 years of age. Although it has been reported to provide approximately 50-80% protection against invasive disease in the general elderly population, there is still controversy as to the effectiveness of the PPV in the elderly. METHODS: To evaluate the immune response t

장애인들은 일반인들에 비해서 건강상태가 열악하여 스트레스가 높을 수 있는 반면 심리사회적 자원은 부족하여 상대적으로 우울의 위험이 일반인들 보다 높을 수 있다. 상당수의 기존연구들이 스트레스요인, 자원요인, 및 우울의 관계를 스트레스 대처이론을 이용하여 연구하였지만, 장애인을 대상으로 스트레스 대처이론을 검증한 연구는 거의 없다. 본 연구는 장애인을 대상으로 스트레스, 심리사회적 요인, 및 우울 간의 관계와 경로를 분석하고, 스트레스 대처이론이 장애인에게도 공히 적용되는지 파악하고자 한다. 이를 위하여 장애인에 대한 전국 대표표본인 한국복지패널 장애인부가조사에 응답한 성인 869명의 자료를 분석에 사용하였다. 본 연구에서 장애인의 우울증상 유병율(CESD≥25)은 17.0%(남성 15.5%, 여성 19.1%)로 나타났다. 구조방정식 모형을 사용하여 장애인의 우울에 대한 예측요인을 분석한 결과, 스트레스 요인인 건강상태와 차별경험 모두 우울에 직접적인 영향을 미치는 것이 아니라, 자아

Objective: The aim of this study was to analyze the computed tomographic (CT) findings of atypical adenomatous hyperplasia (AAH) in the lung. Materials and Methods: The CT findings of AAHs in eight patients were retrospectively reviewed. The CT findings of each AAH lesion were evaluated for multiplicity, location, shape, size and internal density of the lesion, the interface between the normal lung and the lesion, the internal features within the lesion and any change of the lesion on the follow

본 연구는 노년기 인지저하가 연령과 성별에 따라 어떠한 양상을 보이는지, 그리고 인지기능에 영향을 미치는 요인이 연령집단별로 어떠한 차이가 있는지를 검증함으로써 인지기능 유지와 인지저하 예방을 위한 함의를 찾는 것을 목적으로 하였다. 분석 자료는 한국고령화패널조사 2차년의 6,437명에 대한 자료를 활용하였고, 분석 방법은 일반선형모형(GLM)과 구조방정식모형의 다중집단분석(Multi-group analysis)을 실시하였다. 연구 결과 노년기 인지기능은 고령노인과 초고령노인 사이에서 급격히 저하되는 것으로 나타났다. 특히 연령이 증가할수록 여성노인에서 더 급격한 인지저하가 나타나, 고령과 초고령에 이를수록 여성노인과 남성노인 간 인지기능 격차가 더 커졌다. 이는 연령과 독립적으로 성별이 인지기능의 위험요인으로 작용함을 의미한다. 다중집단분석 결과, 인지기능에 대한 영향요인이 연령집단별로 유의한 차이가 있었다. 첫째, 친한 사람들과의 만남횟수, 건강상태, 우울, 운동과 같이 변화 가

Repurposing approved drugs is an emerging therapeutic development strategy for Alzheimer's disease (AD). The CDK4/6 inhibitor abemaciclib mesylate is an FDA-approved drug for breast cancer treatment. However, whether abemaciclib mesylate affects Aβ/tau pathology, neuroinflammation, and Aβ/LPS-mediated cognitive impairment is unknown. In this study, we investigated the effects of abemaciclib mesylate on cognitive function and Aβ/tau pathology and found that abemaciclib mesylate improved spatial a