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Hyun-sook Lee

Seoul National University · 生化学・遺伝学・分子生物学

研究室紹介

Professor Hyun-sook Lee's research lab focuses on molecular genetics, plant developmental biology, and advanced materials for sustainable energy solutions. The lab investigates gene functions in plant reproduction and stress responses, particularly through reverse genetics approaches in model plants like *Petunia* and *Oryza sativa* (rice), aiming to understand key regulatory mechanisms in pollen development and seedling establishment. In parallel, the lab explores innovative materials for hydrogen storage, emphasizing nanoconfined hydride composites to enhance kinetics and thermal stability for clean energy applications. These interdisciplinary efforts reflect a strong commitment to addressing global challenges in agriculture and renewable energy.

plant geneticshydrogen storagemesoporous materialsquantitative trait lociBRCA2 function

Research Overview

Papers
260
Total Citations
4,679
Papers (5y)
46
Primary Field
生化学・遺伝学・分子生物学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
46total
2022
2023
2024
2025
2026
Citations per year (5y)
151total
20222023202420252026

Selected Papers

15
1
Article|235 citations·1999
Mitotic Checkpoint Inactivation Fosters Transformation in Cells Lacking the Breast Cancer Susceptibility Gene, Brca2
Hyun‐Sook Lee, Alison Trainer, Lori S. Friedman, Fiona Thistlethwaite, Martin Evans, Bruce A.J. Ponder, Ashok R. Venkitaraman
SJR Q1Molecular CellOA
Molecular BiologyBiochemistry, Genetics and Molecular Biology
2
Article|213 citations·2002
A Dominant-Negative Form of p63 Is Required for Epidermal Proliferation in Zebrafish
Hyun‐Sook Lee, David Kimelman
SJR Q1Developmental CellOA
OncologyMedicine
3
Article|128 citations·2009
BubR1 acetylation at prometaphase is required for modulating APC/C activity and timing of mitosis
Eunhee Choi, Hyerim Choe, Jaewon Min, Ji Yoon Choi, Jimi Kim, Hyun‐Sook Lee
SJR Q1The EMBO JournalOA
Cell BiologyBiochemistry, Genetics and Molecular Biology
4
Article|83 citations·1996
PRK1, a receptor‐like kinase of Petunia inflata, is essential for postmeiotic development of pollen
Hyun‐Sook Lee, Balasulojini Karunanandaa, Andrew G. McCubbin, Simon Gilroy, Teh‐hui Kao
SJR Q1The Plant JournalOA

Summary A pollen‐expressed gene of Petunia inflata that encodes a receptor‐like kinase named PRK1 was previously identified. The extracellular domain of PRK1 contains leucine‐rich repeats which have been implicated in protein—protein interactions, and the cytoplasmic domain was found to autophosphorylate on serine and possibly tyrosine. To investigate the function of PRK1 in pollen development, P. inflata plants were transformed with a construct containing the promoter of a pollen‐expressed gene

Molecular BiologyBiochemistry, Genetics and Molecular Biology
5
Article|73 citations·2012
Mapping and characterization of quantitative trait loci for mesocotyl elongation in rice (Oryza sativa L.)
Hyun‐Sook Lee, Kazuhiro Sasaki, Atsushi Higashitani, Sang-Nag Ahn, Tadashi Sato
SJR Q1RiceOA

Mesocotyl elongation is an important trait for seedling emergence in direct-seeding cultivation in rice. In this study, a backcross inbred line (BIL) population from a cross between Kasalath and Nipponbare was employed to map quantitative trait loci (QTLs) for mesocotyl elongation. A total of 5 QTLs for mesocotyl length were identified on chromosomes 1, 3, 7, 9, and 12 in 2 independent experiments. At all QTL, the Kasalath alleles contributed to an increase in mesocotyl length. Two QTLs (qMel-1

GeneticsBiochemistry, Genetics and Molecular Biology
6
Article|68 citations·2007
Comparative studies on the diversity of the edible mushroom Pleurotus eryngii: ITS sequence analysis, RAPD fingerprinting, and physiological characteristics
Hyeon‐Su Ro, So Yoon Kim, Jae-San Ryu, Che Ok Jeon, Tae Soo Lee, Hyun‐Sook Lee
Mycological Research
PharmacologyMedicine
7
Article|60 citations·2003
Characterization of a novel single-stranded RNA mycovirus in pleurotus ostreatus
Hyun Jae Yu, Dongbin Lim, Hyun‐Sook Lee
SJR Q2Virology
EndocrinologyBiochemistry, Genetics and Molecular Biology
8
Article|55 citations·2011
Enhanced Desorption and Absorption Properties of Eutectic LiBH4–Ca(BH4)2 Infiltrated into Mesoporous Carbon
Hyun‐Sook Lee, Young‐Su Lee, Jin‐Yoo Suh, Minwoo Kim, Jong‐Sung Yu, Young Whan Cho
SJR Q1The Journal of Physical Chemistry C

We present enhanced hydrogen storage properties of the eutectic LiBH 4 –Ca(BH 4 ) 2 composite confined inside a mesoporous carbon scaffold via melt infiltration. The eutectic composition was examined by analyzing the enthalpy of fusion as a function of the LiBH 4 -to-Ca(BH 4 ) 2 ratio. Elemental analysis by energy dispersive X-ray spectroscopy and phase analysis by X-ray diffraction patterns provided both direct and indirect evidence for the infiltration of the LiBH 4 –Ca(BH 4 ) 2 composite into

Materials ChemistryMaterials Science
9
Article|48 citations·2013
Influential Factors on Pro-Environmental Behaviors—A Case Study in Tokyo and Seoul
Hyun‐Sook Lee, Kiyo Kurisu, Keisuke Hanaki
Low Carbon EconomyOA

To develop the low-carbon society, in addition to the efforts by industrial and commercial sectors, promotion of people’s pro-environmental behaviors (PEBs) has become one of the key issues. Some PEBs have been investigated in previous studies, however, the targets were limited to particular behaviors (i.e., recycling, water saving, electricity saving). The holistic view of understanding the characteristics of PEBs has remained insufficient. In this study, we selected 58 daily PEBs from various

Management, Monitoring, Policy and LawEnvironmental Science
10
Article|47 citations·2014
Ratiometric fluorescence detection of Hg(II) in aqueous solutions at physiological pH and live cells with a chemosensor based on tyrosine
Da‐Hye Kim, Junho Seong, Hyun‐Sook Lee, Keun‐Hyeung Lee
SJR Q1Sensors and Actuators B Chemical
SpectroscopyChemistry
11
Article|46 citations·2011
The Breast Cancer Susceptibility Gene BRCA2 Is Required for the Maintenance of Telomere Homeostasis
Jaewon Min, Eun Shik Choi, Kwang‐Woo Hwang, Jimi Kim, Srihari C. Sampath, Ashok R. Venkitaraman, Hyun‐Sook Lee
SJR Q1Journal of Biological ChemistryOA

Inactivating mutations in the breast cancer susceptibility gene BRCA2 cause gross chromosomal rearrangements. Chromosome structural instability in the absence of BRCA2 is thought to result from defective homology-directed DNA repair. Here, we show that BRCA2 links the fidelity of telomere maintenance with genetic integrity. Absence of BRCA2 resulted in signs of dysfunctional telomeres, such as telomere shortening, erosions, and end fusions in proliferating mouse fibroblasts. BRCA2 localized to t

Molecular BiologyBiochemistry, Genetics and Molecular Biology
12
Article|45 citations·1996
Crystal Structures of Escherichia coli Dihydrofolate Reductase Complexed with 5-Formyltetrahydrofolate (Folinic Acid) in Two Space Groups: Evidence for Enolization of Pteridine O4,
Hyun‐Sook Lee, Vicente M. Reyes, Joseph Kraut
SJR Q1Biochemistry

The crystal structure of Escherichia coli dihydrofolate reductase (ecDHFR, EC 1.5.1.3) as a binary complex with folinic acid (5-formyl-5,6,7,8-tetrahydrofolate; also called leucovorin or citrovorum factor) has been solved in two space groups, P6(1) and P6(5), with, respectively, two molecules and one molecule per asymmetric unit. The crystal structures have been refined to an R-factor of 14.2% at resolutions of 2.0 and 1.9 A. The P6(1) structure is isomorphous with several previously reported ec

Molecular BiologyBiochemistry, Genetics and Molecular Biology
13
Article|38 citations·2006
Isolation and characterization of a novel mycovirus, PeSV, in Pleurotus eryngii and the development of a diagnostic system for it
Hyeon‐Su Ro, Eon-Ju Kang, Jae-San Yu, Tae-Soo Lee, Chang‐Won Lee, Hyun‐Sook Lee
SJR Q2Biotechnology Letters
EndocrinologyBiochemistry, Genetics and Molecular Biology
14
Article|38 citations·1995
X-gene Product Antagonizes the p53-mediated Inhibition of Hepatitis B Virus Replication through Regulation of the Pregenomic/Core Promoter
Hyun‐Sook Lee, Young‐Ho Lee, Yunsil Huh, H R Moon, Yungdae Yun
SJR Q1Journal of Biological ChemistryOA

Employing the glutathione S-transferase column retention method and far Western analysis, we found a physical association between tumor suppressor p53 and the hepatitis B virus X-gene product, which led us to study the function of observed interaction in relation to viral propagation. In the cell culture-based in vitro replication system, expression of p53 resulted in dramatic inhibition of viral replication, and this inhibition was relieved by the coexpression of the X-gene product in a dose-de

EpidemiologyMedicine
15
Article|34 citations·2006
A dominant negative form of p63 inhibits apoptosis in a p53-independent manner
Hae‐Ock Lee, Hae‐Ock Lee, Jung-Hwa Lee, Eunhee Choi, Ja Young Seol, Yungdae Yun, Hyun‐Sook Lee, Hyun‐Sook Lee
SJR Q2Biochemical and Biophysical Research Communications
OncologyMedicine

Research Areas

Molecular BiologyGeneticsCell BiologyMaterials ChemistryPlant ScienceEndocrinology

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