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Hyungkeon Kim

Sungkyunkwan University · 医学

研究室紹介

Professor Hyungkeon Kim's research lab specializes in biomedical engineering and computational biomechanics, focusing on the development of patient-specific simulation models for heart valve diseases and their surgical repair. The lab integrates advanced imaging, finite element analysis, and personalized computational modeling to study the biomechanical mechanisms of valvular dysfunction, such as leaflet prolapse and calcification. Additionally, the lab applies cutting-edge technologies like machine learning and deep learning to medical diagnostics, including fall detection systems and agricultural image segmentation, while also contributing to molecular and vascular imaging for early atherosclerosis detection.

biomedical simulationheart valve diseasemachine learning in healthcarecomputational biomechanicsmedical image analysis

Research Overview

Papers
219
Total Citations
3,741
Papers (5y)
39
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
39total
2021
2022
2023
2024
2025
Citations per year (5y)
325total
20212022202320242025

Selected Papers

15
1
Article|125 citations·2007
Dynamic Simulation of Bioprosthetic Heart Valves Using a Stress Resultant Shell Model
Hyunggun Kim, Jia Lu, Michael S. Sacks, K. B. Chandran
SJR Q2Annals of Biomedical Engineering
Cardiology and Cardiovascular MedicineMedicine
2
Article|60 citations·2006
Dynamic Simulation Pericardial Bioprosthetic Heart Valve Function
Hyunggun Kim, Jia Lu, Michael S. Sacks, K. B. Chandran
SJR Q3Journal of Biomechanical Engineering

While providing nearly trouble-free function for 10-12 years, current bioprosthetic heart valves (BHV) continue to suffer from limited long-term durability. This is usually a result of leaflet calcification and/or structural degeneration, which may be related to regions of stress concentration associated with complex leaflet deformations. In the current work, a dynamic three-dimensional finite element analysis of a pericardial BHV was performed with a recently developed FE implementation of the

Cardiology and Cardiovascular MedicineMedicine
3
Article|58 citations·2006
An Experimentally Derived Stress Resultant Shell Model for Heart Valve Dynamic Simulations
Hyunggun Kim, K. B. Chandran, Michael S. Sacks, Jia Lu
SJR Q2Annals of Biomedical Engineering
Cardiology and Cardiovascular MedicineMedicine
4
Article|54 citations·2013
Mitral Valve Repair Using ePTFE Sutures for Ruptured Mitral Chordae Tendineae: A Computational Simulation Study
Yonghoon Rim, Susan T. Laing, David D. McPherson, Hyunggun Kim
SJR Q2Annals of Biomedical Engineering
Cardiology and Cardiovascular MedicineMedicine
5
Article|52 citations·2012
Direct detection of tetrahydrobiopterin (BH4) and dopamine in rat brain using liquid chromatography coupled electrospray tandem mass spectrometry
Hak Rim Kim, Hak Rim Kim, Tae-Hyun Kim, Sung-Hyun Hong, Hyunggun Kim, Hyunggun Kim
SJR Q2Biochemical and Biophysical Research Communications
Clinical BiochemistryBiochemistry, Genetics and Molecular Biology
6
Article|49 citations·2014
Quantification of Neurotransmitters in Mouse Brain Tissue by Using Liquid Chromatography Coupled Electrospray Tandem Mass Spectrometry
Tae-Hyun Kim, Juhee Choi, Hyunggun Kim, Hyung-Gun Kim, Hak Rim Kim, Hak Rim Kim
SJR Q2Journal of Analytical Methods in ChemistryOA

A simple and rapid liquid chromatography tandem mass spectrometry method has been developed for the determination of BH4, DA, 5-HT, NE, EP, Glu, and GABA in mouse brain using epsilon-acetamidocaproic acid and isotopically labeled neurotransmitters as internal standards. Proteins in the samples were precipitated by adding acetonitrile, and then the supernatants were separated by a Sepax Polar-Imidazole (2.1 mm × 100 mm, i.d., 3 μm) column by adding a mixture of 10 mM ammonium formate in acetonitr

Cellular and Molecular NeuroscienceNeuroscience
7
Article|43 citations·2010
Chronic 835-MHz radiofrequency exposure to mice hippocampus alters the distribution of calbindin and GFAP immunoreactivity
Dhiraj Maskey, Jonu Pradhan, Bijay Aryal, Chang-Min Lee, In-Young Choi, Ki‐Sup Park, Seok Bae Kim, Hyunggun Kim, Myeung Ju Kim
SJR Q2Brain Research
BiophysicsBiochemistry, Genetics and Molecular Biology
8
Article|41 citations·2014
Determinants of Housing Prices in Hong Kong: A Box-Cox Quantile Regression Approach
Hyunggun Kim, Kwong-Chin Hung, Sung Y. Park
SJR Q1The Journal of Real Estate Finance and Economics
Economics and EconometricsEconomics, Econometrics and Finance
9
Article|40 citations·2013
The effect of patient-specific annular motion on dynamic simulation of mitral valve function
Yonghoon Rim, David D. McPherson, K. B. Chandran, Hyunggun Kim
SJR Q1Journal of Biomechanics
Cardiology and Cardiovascular MedicineMedicine
10
Article|36 citations·2015
Personalized Computational Modeling of Mitral Valve Prolapse: Virtual Leaflet Resection
Yonghoon Rim, Ahnryul Choi, David D. McPherson, Hyunggun Kim
SJR Q1PLoS ONEOA

Posterior leaflet prolapse following chordal elongation or rupture is one of the primary valvular diseases in patients with degenerative mitral valves (MVs). Quadrangular resection followed by ring annuloplasty is a reliable and reproducible surgical repair technique for treatment of posterior leaflet prolapse. Virtual MV repair simulation of leaflet resection in association with patient-specific 3D echocardiographic data can provide quantitative biomechanical and physiologic characteristics of

Cardiology and Cardiovascular MedicineMedicine
11
Article|32 citations·2021
Weakly Supervised Crop Area Segmentation for an Autonomous Combine Harvester
Wan-Soo Kim, Dae-Hyun Lee, Taehyeong Kim, Hyunggun Kim, Taeyong Sim, Yong–Joo Kim
SJR Q1SensorsOA

Machine vision with deep learning is a promising type of automatic visual perception for detecting and segmenting an object effectively; however, the scarcity of labelled datasets in agricultural fields prevents the application of deep learning to agriculture. For this reason, this study proposes weakly supervised crop area segmentation (WSCAS) to identify the uncut crop area efficiently for path guidance. Weakly supervised learning has advantage for training models because it entails less labor

Plant ScienceAgricultural and Biological Sciences
12
Article|30 citations·2018
A Novel Detection Model and Its Optimal Features to Classify Falls from Low- and High-Acceleration Activities of Daily Life Using an Insole Sensor System
Benjamin Cates, Taeyong Sim, Hyun Heo, Bori Kim, Hyunggun Kim, Joung Hwan Mun
SJR Q1SensorsOA

In order to overcome the current limitations in current threshold-based and machine learning-based fall detectors, an insole system and novel fall classification model were created. Because high-acceleration activities have a high risk for falls, and because of the potential damage that is associated with falls during high-acceleration activities, four low-acceleration activities, four high-acceleration activities, and eight types of high-acceleration falls were performed by twenty young male su

Computer Vision and Pattern RecognitionComputer Science
13
Article|27 citations·2021
Potent antiviral activity of Agrimonia pilosa, Galla rhois, and their components against SARS-CoV-2
Yeong‐Geun Lee, Kyung‐Won Kang, Woojae Hong, Yeon Hwa Kim, Jen Taek Oh, Dae Won Park, Minsung Ko, Yun-Feng Bai, Young-Jin Seo, Sang-Myeong Lee, Hyunggun Kim, Se Chan Kang
SJR Q2Bioorganic & Medicinal ChemistryOA
Infectious DiseasesMedicine
14
Article|27 citations·2010
In Vivo Volumetric Intravascular Ultrasound Visualization of Early/Inflammatory Arterial Atheroma Using Targeted Echogenic Immunoliposomes
Hyunggun Kim, Melanie R. Moody, Susan T. Laing, Patrick Kee, Shaoling Huang, Melvin E. Klegerman, David D. McPherson
SJR Q1Investigative RadiologyOA

This study demonstrates specific highlighting of early/inflammatory atheroma in vivo using anti-ICAM-1 ELIP. Three-dimensional IVUS reconstruction provides good visualization of plaque distribution in the arterial wall. This novel methodology may help to detect and diagnose pathophysiologic development of all stages of atheroma formation in vivo and quantitate plaque volume for serial and long-term atherosclerotic treatment studies.

SurgeryMedicine
15
Article|27 citations·2022
Network pharmacology and molecular docking approaches to elucidate the potential compounds and targets of Saeng-Ji-Hwang-Ko for treatment of type 2 diabetes mellitus
Minsung Ko, Youllee Kim, Hyun Hak Kim, Soohwan Jeong, Do-Hee Ahn, Sang J. Chung, Hyunggun Kim
SJR Q1Computers in Biology and Medicine
Computational Theory and MathematicsComputer Science

Research Areas

Cardiology and Cardiovascular MedicineBiomedical EngineeringSurgeryMolecular BiologyNeurologyBiophysics

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