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In‐Soo Kim

Yonsei University · 医学

研究室紹介

Professor In-Soo Kim's research lab specializes in sustainable materials and environmental biotechnology, focusing on the development of advanced nanomaterials for food packaging and wastewater treatment. The lab investigates zinc oxide nanoparticles (ZnO NPs) for active food packaging applications, emphasizing antimicrobial performance and biodegradable bionanocomposites. It also pioneers microbial consortium-based solutions for treating recalcitrant industrial wastewater, particularly from tanneries, using eco-friendly, chemical-free approaches. Additionally, the lab explores protein engineering for therapeutic applications, such as long-acting antidiabetic conjugates using human serum albumin and PEGylation.

nanomaterialswastewater treatmentbiodegradable packagingmicrobial consortiumprotein conjugation

Research Overview

Papers
179
Total Citations
2,803
Papers (5y)
35
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
35total
2021
2022
2023
2024
2025
Citations per year (5y)
122total
20212022202320242025

Selected Papers

15
1
Article|426 citations·2020
ZnO Nanostructures in Active Antibacterial Food Packaging: Preparation Methods, Antimicrobial Mechanisms, Safety Issues, Future Prospects, and Challenges
In‐Soo Kim, Viswanathan Karthika, Gopinath Kasi, Sarinthip Thanakkasaranee, Kambiz Sadeghi, Jongchul Seo
SJR Q1Food Reviews InternationalOA

Packaging of food products is one of the most important stages of the food supply chain. Nano-size materials for packing food substances with appropriate properties result in better packaging performance and longer food shelf-life. In this review, the application of ZnO nano-size in active packaging of foods is discussed to identify gaps in applications for food packaging and safety. First, the crystal structures and morphologies of modified ZnO nanoparticles (ZnO NPs) are presented, and their s

BiomaterialsMaterials Science
2
Article|175 citations·2012
Doxorubicin-loaded highly porous large PLGA microparticles as a sustained- release inhalation system for the treatment of metastatic lung cancer
In‐Soo Kim, Hyeong Jun Byeon, Tae Hyung Kim, Eun Seong Lee, Kyung Taek Oh, Beom Soo Shin, Kang Choon Lee, Yu Seok Youn
SJR Q1Biomaterials
Pulmonary and Respiratory MedicineMedicine
3
Article|162 citations·2019
Poly(Lactic Acid)/ZnO Bionanocomposite Films with Positively Charged ZnO as Potential Antimicrobial Food Packaging Materials
In‐Soo Kim, Viswanathan Karthika, Gopinath Kasi, Kambiz Sadeghi, Sarinthip Thanakkasaranee, Jongchul Seo
SJR Q1PolymersOA

A series of PLA/ZnO bionanocomposite films were prepared by introducing positively surface charged zinc oxide nanoparticles (ZnO NPs) into biodegradable poly(lactic acid) (PLA) by the solvent casting method, and their physical properties and antibacterial activities were evaluated. The physical properties and antibacterial efficiencies of the bionanocomposite films were strongly dependent on the ZnO NPs content. The bionanocomposite films with over 3% ZnO NPs exhibited a rough surface, poor disp

BiomaterialsMaterials Science
4
Article|137 citations·2013
Doxorubicin-loaded porous PLGA microparticles with surface attached TRAIL for the inhalation treatment of metastatic lung cancer
In‐Soo Kim, Hyeong Jun Byeon, Tae Hyung Kim, Eun Seong Lee, Kyung Taek Oh, Beom Soo Shin, Kang Choon Lee, Yu Seok Youn
SJR Q1Biomaterials
Pulmonary and Respiratory MedicineMedicine
5
Article|75 citations·2018
Long-term exposure of fine particulate matter air pollution and incident atrial fibrillation in the general population: A nationwide cohort study
In‐Soo Kim, Pil‐Sung Yang, Jinae Lee, Hee Tae Yu, Tae‐Hoon Kim, Jae‐Sun Uhm, Hui‐Nam Pak, Moon‐Hyoung Lee, Boyoung Joung
SJR Q1International Journal of CardiologyOA
Health, Toxicology and MutagenesisEnvironmental Science
6
Article|61 citations·2013
Full-scale biological treatment of tannery wastewater using the novel microbial consortium BM-S-1
In‐Soo Kim, Kalu I. Ekpeghere, Shin-Young Ha, Bong Soo Kim, Bongkeun Song, Jong-Tae Kim, Hong Gi Kim, Sung‐Cheol Koh
SJR Q2Journal of Environmental Science and Health Part A

In order to develop a more effective and eco-friendly treatment technology, a full-scale tannery wastewater treatment plant with a sludge digestion system was augmented with a novel microbial consortium (BM-S-1). The aim of this study was to determine if the BM-S-1 could successfully treat the tannery wastewater in a full-scale treatment system without chemical pretreatment and to investigate effect of the augmentation on sludge production. Chemical oxygen demand (COD), total nitrogen (TN), tota

Health, Toxicology and MutagenesisEnvironmental Science
7
Review|60 citations·2018
Non-vitamin K antagonist oral anticoagulants have better efficacy and equivalent safety compared to warfarin in elderly patients with atrial fibrillation: A systematic review and meta-analysis
In‐Soo Kim, Hyun-Jung Kim, Tae‐Hoon Kim, Jae‐Sun Uhm, Boyoung Joung, Moon‐Hyoung Lee, Hui‐Nam Pak
SJR Q2Journal of CardiologyOA
Cardiology and Cardiovascular MedicineMedicine
8
Article|43 citations·2019
Long-term fine particulate matter exposure and cardiovascular mortality in the general population: a nationwide cohort study
In‐Soo Kim, Pil‐Sung Yang, Jinae Lee, Hee Tae Yu, Tae‐Hoon Kim, Jae‐Sun Uhm, Jong‐Youn Kim, Hui‐Nam Pak, Moon‐Hyoung Lee, Boyoung Joung
SJR Q2Journal of CardiologyOA

In the Korean general population exposed to high-air pollution, long-term PM<sub>2.5</sub> exposure was linearly associated with increased risk for all-cause and cardiovascular mortality, especially above 18 μg/m<sup>3</sup> of PM<sub>2.5</sub>.

Health, Toxicology and MutagenesisEnvironmental Science
9
Article|41 citations·2000
Geological structures and evolution of the Miocene Eoil Basin, southeastern Korea
Moon Son, Hyunju Seo, In‐Soo Kim
SJR Q2Geosciences Journal
GeologyEarth and Planetary Sciences
10
Article|41 citations·2013
An eco-friendly treatment of tannery wastewater using bioaugmentation with a novel microbial consortium
In‐Soo Kim, Kaluibe Ekpeghere, Shin-Young Ha, Soo-Hyeon Kim, Bong Soo Kim, Bongkeun Song, Jongsik Chun, Jae‐Soo Chang, Hong Gi Kim, Sung‐Cheol Koh
SJR Q2Journal of Environmental Science and Health Part A

A novel microbial consortium (BM-S-1) enriched from natural soils was successfully used to treat tannery wastewater from leather manufacturing industries in Korea on a pilot scale. The objective of this study was to determine whether augmentation with a novel microbial consortium BM-S-1could successfully treat the recalcitrant wastewater without chemical pre-treatment in a tannery wastewater treatment system. Chemical oxygen demand (COD), total nitrogen (TN) and total phosphorus (TP) were monito

Health, Toxicology and MutagenesisEnvironmental Science
11
Article|41 citations·2010
Synthesis and Evaluation of Human Serum Albumin-Modified Exendin-4 Conjugate via Heterobifunctional Polyethylene Glycol Linkage with Protracted Hypoglycemic Efficacy
In‐Soo Kim, Tae Hyung Kim, Kyungwan Ma, Eun Seong Lee, Dongin Kim, Kyung Taek Oh, Don Haeng Lee, Kang Choon Lee, Yu Seok Youn
SJR Q1Bioconjugate Chemistry

Albumin conjugation is considered to be one of the most effective means of protracting the short in vivo lifespans of peptides and proteins. Here, we present a new long-acting antidiabetic exendin-4 conjugate linked with human serum albumin (HSA) via polyethylene glycol (PEG). As a first step toward synthesizing this conjugate, three artificial sulfhydryl groups were introduced in HSA using 2-iminothiolane at pH 8.0. This thiolated HSA was further reacted with the monomer fraction of exendin-4 (

Molecular BiologyBiochemistry, Genetics and Molecular Biology
12
Article|39 citations·2020
Preparation and characterization of positively surface charged zinc oxide nanoparticles against bacterial pathogens
In‐Soo Kim, Viswanathan Karthika, Gopinath Kasi, Kambiz Sadeghi, Sarinthip Thanakkasaranee, Jongchul Seo
SJR Q2Microbial Pathogenesis
Materials ChemistryMaterials Science
13
Article|38 citations·2017
Association of air pollution with increased incidence of ventricular tachyarrhythmias recorded by implantable cardioverter defibrillators: Vulnerable patients to air pollution
In‐Soo Kim, Jungwoo Sohn, Seung‐Jun Lee, Jin‐Kyu Park, Jae‐Sun Uhm, Hui‐Nam Pak, Moon‐Hyoung Lee, Changsoo Kim, Boyoung Joung
SJR Q1International Journal of CardiologyOA
Health, Toxicology and MutagenesisEnvironmental Science
14
Article|34 citations·2013
The Effect of Systemically Administered Bisphosphonates on Bony Healing After Tooth Extraction and Osseointegration of Dental Implants in the Rabbit Maxilla
In‐Soo Kim, HyungChun Ki, Won Lee, Hee‐Sung Kim, Jun‐Beom Park
SJR Q2The International Journal of Oral & Maxillofacial Implants

This study showed that administration of bisphosphonates interferes with normal bone remodeling after tooth extraction. The experimental groups showed good initial stability, but long-term healing around the implants was impaired. Within the limits of this study, it may be suggested that patients taking bisphosphonates should be treated with caution when performing tooth extraction or placing dental implants.

OncologyMedicine
15
Article|28 citations·2019
Clinical Usefulness of Computational Modeling-Guided Persistent Atrial Fibrillation Ablation: Updated Outcome of Multicenter Randomized Study
In‐Soo Kim, Byounghyun Lim, Jaemin Shim, Minki Hwang, Hee Tae Yu, Tae‐Hoon Kim, Jae‐Sun Uhm, Sung‐Hwan Kim, Boyoung Joung, Young Keun On, Seil Oh, Yong‐Seog Oh
SJR Q2Frontiers in PhysiologyOA

This study was registered with the ClinicalTrials.gov, number NCT02171364.

Cardiology and Cardiovascular MedicineMedicine

Research Areas

Cardiology and Cardiovascular MedicinePulmonary and Respiratory MedicineHealth, Toxicology and MutagenesisPlant ScienceSurgeryMaterials Chemistry

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