Ja‐Young Kwon

Preeclampsia is one of the leading causes of maternal and fetal morbidity and mortality. Due to the lack of effective preventive measures, its prediction is essential to its prompt management. This study aimed to develop models using machine learning to predict late-onset preeclampsia using hospital electronic medical record data. The performance of the machine learning based models and models using conventional statistical methods were also compared. A total of 11,006 pregnant women who receive

A recent study by McDonnold and coinvestigators published in Am J Obstet Gynecol reports an association between human papillomavirus (HPV) infection and preeclampsia. The investigation was based on the hypothesis that HPV trophoblast infection results in failed trophoblast invasion, and placental dysfunction and hypoxia. The findings from this study along with previous data addressing the relationship between viral infection and obstetrical complications highlight the relevance of viral infectio

Intrauterine tamponade with a Bakri balloon is an adequate adjunct management for postpartum hemorrhage following cesarean section for placenta previa to preserve the uterus. This method is simple to apply, non-invasive, and inexpensive. However, possible factors related to failure of Bakri balloon tamponade for placenta previa patients such as prior cesarean section history, anterior placentation, thrombocytopenia, presence of DIC at the time of catheter insertion, and catheter drainage volume

AIM: To evaluate the relationship between abnormal Doppler velocimetry and adverse perinatal outcomes in pregnancies with borderline amniotic fluid index (AFI). METHODS: Medical records of 3740 pregnancies with known AFI and Doppler velocimetry measurements within 2 weeks of delivery, and delivered between January 1996 and December 2003, were retrospectively analyzed. Borderline AFI was defined as 5 cm < AFI < or = 8 cm. For the umbilical artery, Doppler velocimetry was considered abnormal when

BACKGROUND/AIMS: We compared the numbers of endothelial progenitor cells (EPCs) in umbilical cord blood in severe preeclampsia and normal pregnancy, along with the cord blood plasma levels of free VEGF and sVEGFR-1. METHODS: Umbilical cord blood EPC counts in severe preeclampsia (n = 15) and gestationally matched normal pregnant women (n = 30) were retrospectively analyzed. Cord plasma free VEGF and sVEGFR-1 levels were measured by enzyme immunoassay. RESULTS: Significantly higher systolic blood

PROBLEM: The pathophysiology of preeclampsia (PE) is believed to be associated with a systemic inflammatory response, but few inflammatory markers are currently available to predict PE. Therefore, the aim of this study was to compare the serum delta neutrophil index (DNI) between normal and preeclamptic women. METHODS: Sixty-five patients with mild preeclampsia (mPE), 147 patients with severe preeclampsia (sPE), and 163 women with normal pregnancy were included in this study. Maternal laboratory

OBJECTIVE: To evaluate the feasibility of Volume NT(TM) , a new technique that automatically archives mid-sagittal plane views and measures the maximum nuchal translucency (NT) thickness, by comparing its measurements with those made with conventional two- (2D) and three-dimensional (3D) techniques. METHODS: This was a prospective study of 130 singleton pregnancies undergoing NT screening at 11 + 0 to 13 + 6 weeks of gestation. Fetuses with enlarged NT or multiple anomalies and those in the pron

PROBLEM: The lymphatic vasculature controls leukocytes trafficking and limits the adaptive immune response. In previous models of preeclampsia (PE), defective immune function caused by disruption of lymphangiogenesis was shown to be involved in the disease pathophysiology. Especially, the dysfunction of regulatory T cells (Treg) at the maternal-fetal interface may be one of the causes of severe PE. In particular, activation of Tregs to obtain immune tolerance requires adequate antigen presentati

In pregnancy complicated by severe preeclampsia, urinary nephrin shedding, reflecting the damage in the glomerular slit diaphragm, was observed.