Jeong Ji-heon
Sungkyunkwan University · 医学
研究室紹介
Professor Jeong Ji-heon's research lab specializes in developing advanced nanotherapeutic systems for cancer treatment, with a focus on targeted, stimuli-responsive drug delivery. The lab integrates nanomaterials, immunotherapy, and tumor microenvironment modulation to enhance therapeutic precision and efficacy in aggressive cancers such as colorectal cancer, triple-negative breast cancer, and neurodegenerative disorders linked to drug abuse. Key research directions include designing multifunctional gold nanoparticles and ROS-responsive nanocarriers for chemo-photothermal therapy, dual-targeted delivery to overcome drug resistance, and exploring the molecular mechanisms of neurotoxicity in methamphetamine use. The lab also pioneers innovative 3D cell culture platforms to better model tumor physiology and improve preclinical drug testing.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Colorectal cancer (CRC) is the third leading cause of cancer-related death worldwide. The prognosis and overall survival of CRC are known to be significantly correlated with the overexpression of PD-L1. Since combination therapies can significantly improve therapeutic efficacy, we constructed doxorubicin (DOX) conjugated and anti-PD-L1 targeting gold nanoparticles (PD-L1-AuNP-DOX) for the targeted chemo-photothermal therapy of CRC. DOX and anti-PD-L1 antibody were conjugated to the α-terminal en
: 3D-cultured MSCs; MSCs: mesenchymal stromal cells; NFE2L2/NRF2: nuclear factor, erythroid 2 like 2; PGE2: prostaglandin E2; PIK3C3/VPS34: phosphatidylinositol 3-kinase catalytic subunit type 3; PINK1: PTEN induced kinase 1; ROS: reactive oxygen species; siRNA: small interfering RNA; SIRT1: sirtuin 1; SOD2: superoxide dismutase 2; SQSTM1/p62: sequestosome 1; TGFB/TGF-β: transforming growth factor beta.
Methamphetamine (MA) is a extremely addictive psychostimulant drug with a significant abuse potential. Long-term MA exposure can induce neurotoxic effects through oxidative stress, mitochondrial functional impairment, endoplasmic reticulum stress, the activation of astrocytes and microglial cells, axonal transport barriers, autophagy, and apoptosis. However, the molecular and cellular mechanisms underlying MA-induced neurotoxicity remain unclear. MA abuse increases the chances of developing neur
Amalgamation of the reactive oxygen species (ROS)-responsive stimulus with nanoparticles has gained considerable interest owing to their high tumor specificity. Hypoxia plays a pivotal role in the acceleration of intracellular ROS production. Herein, we report the construction of a cancer cell (PD-L1)- and ROS-responsive, dual-targeted, temozolomide (TMZ)-laden nanosystem which offers a better anticancer effect in a hypoxic tumor microenvironment. A dual-targeted system boosted permeation in the