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Jung Suk Lee

Yonsei University · 医学

研究室紹介

Professor Jung Suk Lee's research lab specializes in regenerative dentistry and biomaterials, focusing on periodontal and oral bone regeneration. The lab investigates the efficacy of growth factors such as rhGDF-5 and rhBMP-2, as well as various bone graft substitutes—including deproteinized bovine and porcine bone minerals—used in socket and sinus augmentation. Key research directions include quantitative assessment of ridge preservation, dimensional stability, and histological outcomes in both animal models and clinical trials. The lab also explores digital and clinical measurement techniques for periodontal parameters, emphasizing accuracy and reliability in clinical evaluation.

periodontal regenerationbone graftinggrowth factorsridge preservationclinical measurement accuracy

Research Overview

Papers
357
Total Citations
5,806
Papers (5y)
55
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
55total
2022
2023
2024
2025
2026
Citations per year (5y)
307total
20222023202420252026

Selected Papers

15
1
Article|90 citations·2006
Heparin conjugated polymeric micelle for long-term delivery of basic fibroblast growth factor
Jung‐Seok Lee, Dong Hyun Go, Jin Woo Bae, Seung Jin Lee, Ki Dong Park
SJR Q1Journal of Controlled Release
Cell BiologyBiochemistry, Genetics and Molecular Biology
2
Article|89 citations·2007
Controlled dual release of basic fibroblast growth factor and indomethacin from heparin-conjugated polymeric micelle
Jung‐Seok Lee, Jin Woo Bae, Yoon Ki Joung, Seung Jin Lee, Dong Keun Han, Ki Dong Park
SJR Q1International Journal of Pharmaceutics
Cell BiologyBiochemistry, Genetics and Molecular Biology
3
Article|76 citations·2010
Thermosensitive hydrogel-containing polymersomes for controlled drug delivery
Jung‐Seok Lee, Wei Zhou, Fenghua Meng, Dianwen Zhang, Cees Otto, Jan Feijén
SJR Q1Journal of Controlled Release
Molecular MedicineBiochemistry, Genetics and Molecular Biology
4
Article|63 citations·2010
Periodontal wound healing/regeneration following implantation of recombinant human growth/differentiation factor‐5 in a β‐tricalcium phosphate carrier into one‐wall intrabony defects in dogs
Jung‐Seok Lee, Ulf M. E. Wikesjö, Ui‐Won Jung, Seong‐Ho Choi, Susanne Pippig, Michael Siedler, Chong‐Kwan Kim
SJR Q1Journal Of Clinical PeriodontologyOA

OBJECTIVE: Recombinant human growth/differentiation factor-5 (rhGDF-5) is being evaluated as a candidate therapy in support of periodontal regeneration. The objective of this study was to evaluate periodontal wound healing/regeneration following the application of rhGDF-5 on a particulate beta-tricalcium phosphate (beta-TCP) carrier using an established defect model. MATERIALS AND METHODS: Bilateral 4 x 5 mm (width x depth), one-wall, critical-size, intrabony periodontal defects were surgically

UrologyMedicine
5
Article|62 citations·2018
Alveolar ridge regeneration of damaged extraction sockets using deproteinized porcine versus bovine bone minerals: A randomized clinical trial
Jung‐Seok Lee, Jae‐Kook Cha, Chang‐Sung Kim
SJR Q1Clinical Implant Dentistry and Related ResearchOA

BACKGROUNDS: Clinical benefits in bone grafting of intact extraction socket have been widely known, but limited evidence is available for the procedure in damaged extraction sockets due to periodontal disease. PURPOSE: This study aimed to determine the dimensional alteration of alveolar ridge following bone grafting of damaged extraction sockets, and compare the outcomes of using deproteinized bovine (DBBM) versus porcine bone mineral (DPBM) in the damaged sockets. MATERIALS AND METHODS: One hun

Oral SurgeryDentistry
6
Article|59 citations·2016
Randomized Clinical Trial of Maxillary Sinus Grafting using Deproteinized Porcine and Bovine Bone Mineral
Jung‐Seok Lee, Hyun‐Ki Shin, Jeong‐Ho Yun, Kyoo‐Sung Cho
SJR Q1Clinical Implant Dentistry and Related ResearchOA

BACKGROUND: Deproteinized porcine bone mineral (DPBM) was recently developed and commercially available in maxillary sinus grafting, in which demineralized bovine bone mineral (DBBM) was widely used. OBJECTIVES: The present randomized controlled clinical trial aimed to compare histological bone quality and radiographic volume stability in maxillary sinuses grafted with DPBM and DBBM. MATERIALS AND METHODS: Twenty sinuses in 16 participants were enrolled and randomly allocated to control and test

Oral SurgeryDentistry
7
Article|59 citations·2015
Ridge regeneration of damaged extraction sockets using rhBMP‐2: an experimental study in canine
Jung‐Seok Lee, Jae‐Suk Jung, Gun‐Il Im, Byung‐Soo Kim, Kyoo‐Sung Cho, Chang‐Sung Kim
SJR Q1Journal Of Clinical PeriodontologyOA

OBJECTIVES: This study evaluated the dimensional ridge alteration in a buccal-bone-deficient extraction socket, and ridge regeneration following socket grafting accompanied by recombinant human bone morphogenetic protein 2 (rhBMP-2) or a collagen membrane covering. MATERIAL AND METHODS: In five beagle dogs, entire buccal bone of the extracted sockets of premolars was surgically removed and immediately grafted using one of the following graft protocols: (1) sham surgery without any grafting, and

UrologyMedicine
8
Article|59 citations·2015
Human bone marrow stem cells cultured under hypoxic conditions present altered characteristics and enhanced in vivo tissue regeneration
Jung‐Seok Lee, Jung‐Chul Park, Tae‐Wan Kim, Byung-Joo Jung, Youngseok Lee, Eun-Kyung Shim, Soyon Park, Eun Young Choi, Kyoo‐Sung Cho, Chang‐Sung Kim
SJR Q1BoneOA
GeneticsMedicine
9
Article|56 citations·2020
Digital scanning is more accurate than using a periodontal probe to measure the keratinized tissue width
Jung‐Seok Lee, Yoon-Sun Jeon, Franz Josef Strauß, Hoi‐In Jung, Reinhard Gruber
SJR Q1Scientific ReportsOA

This study aimed to compare the accuracy and reliability of digital versus conventional clinical measurements of the width of keratinized tissue. To this end, the keratinized tissue width was measured at 110 tooth sites in 5 pig jaws. The measurements were made at each site using three-dimensional (3D) scanned images and a periodontal probe. The actual keratinized tissue width was subsequently measured on histologic slides prepared from the same sites, and differences between the histologic slid

UrologyMedicine
10
Article|55 citations·2012
Long‐term retrospective study of narrow implants for fixed dental prostheses
Jung‐Seok Lee, H. Mike Kim, Chang‐Sung Kim, Seong‐Ho Choi, Jung‐Kiu Chai, Ui‐Won Jung
SJR Q1Clinical Oral Implants ResearchOA

OBJECTIVE: The objectives of this study were to analyze retrospectively the long-term survival and success rates of Narrow implants (NIs) placed with various implant systems, and the association with biological and technical complications. MATERIAL AND METHODS: In total, 338 patients (men = 45.6%, women = 54.4%) who received 541 NIs (≤3.5 mm in diameter) for fixed prostheses were enrolled in this retrospective study. The mean marginal bone level (MMBL) change was calculated. Life table analysis

Oral SurgeryDentistry
11
Article|49 citations·2019
Histologic analysis following grafting of damaged extraction sockets using deproteinized bovine or porcine bone mineral: A randomized clinical trial
Tae‐Hwan Koo, Young Woo Song, Jae‐Kook Cha, Ui‐Won Jung, Chang‐Sung Kim, Jung‐Seok Lee
SJR Q1Clinical Oral Implants ResearchOA

OBJECTIVES: This study histologically analyzed biopsy samples obtained from sites of damaged extraction socket grafting using deproteinized bovine bone mineral (DBBM) or deproteinized porcine bone mineral (DPBM) with coverage by a collagen membrane. MATERIAL AND METHODS: One hundred patients participated in this randomized controlled clinical trial of extraction socket grafts performed in cases of periodontally compromised teeth. All participants were blinded to their group allocations, and each

Oral SurgeryDentistry
12
Article|42 citations·2021
Adjunctive use of metronidazole‐minocycline ointment in the nonsurgical treatment of peri‐implantitis: A multicenter randomized controlled trial
Seung‐Hyun Park, Young Woo Song, Jae‐Kook Cha, Jung‐Seok Lee, Young‐Taek Kim, Hyun‐Seung Shin, Dong‐Won Lee, Jae Hyun Lee, Chang‐Sung Kim
SJR Q1Clinical Implant Dentistry and Related ResearchOA

BACKGROUND: Clinical benefits of local antibiotics as an adjunct to nonsurgical treatment of peri-implantitis have been widely reported, but most studies evaluated incipient peri-implantitis lesions, and showed incomplete treatment success rates. PURPOSE: To assess the clinical and microbiological outcomes of administering metronidazole in combination with minocycline as a local adjunct to the nonsurgical treatment of peri-implantitis. MATERIALS AND METHODS: One hundred and eighteen subjects wit

Oral SurgeryDentistry
13
Article|38 citations·2012
Periodontal tissue reaction to customized nano-hydroxyapatite block scaffold in one-wall intrabony defect: a histologic study in dogs
Jung‐Seok Lee, Weon-Yeong Park, Jae‐Kook Cha, Ui‐Won Jung, Chang‐Sung Kim, Yong‐Keun Lee, Seong‐Ho Choi
SJR Q1Journal of Periodontal & Implant ScienceOA

In the limitation of this study, customized n-HA block could provide a space for periodontal tissue engineering, with minimal inflammation.

Biomedical EngineeringEngineering
14
Article|37 citations·2018
Retrospective radiographic observational study of 1692 Straumann tissue‐level dental implants over 10 years: I. Implant survival and loss pattern
Seungmin Kim, Ui‐Won Jung, Kyoo‐Sung Cho, Jung‐Seok Lee
SJR Q1Clinical Implant Dentistry and Related ResearchOA

BACKGROUND: Implant dentistry is progressing based on extensive scientific results including preclinical and clinical studies. Researchers and clinicians have focused on implant designs and surface characteristics, which has resulted in various features being developed and introduced for enhancing osseointegration and reducing complications. PURPOSE: The purpose of this study was to determine the cumulative survival rates of Straumann tissue-level dental implants over a 10-year period and identi

Oral SurgeryDentistry
15
Article|33 citations·2020
Clinical factors influencing implant positioning by guided surgery using a nonmetal sleeve template in the partially edentulous ridge: Multiple regression analysis of a prospective cohort
Jin‐Young Park, Young Woo Song, Seung‐Hyun Park, Jang‐Hyun Kim, Ji‐Man Park, Jung‐Seok Lee
SJR Q1Clinical Oral Implants ResearchOA

OBJECTIVE: To determine the positional accuracy of implants placed with a three-dimensionally printed template having nonmetal sleeves and to determine the contributing factors to observed deviations. MATERIALS AND METHODS: One hundred and eighty-seven implants placed in 72 patients were analyzed. Presurgical intraoral scans and cone-beam computed tomography images obtained before and after surgery were superimposed, and vertical, angular, platform, and apex deviations were measured between the

Oral SurgeryDentistry

Research Areas

Oral SurgeryUrologyBiomedical EngineeringPeriodonticsSurgeryImmunology

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