Lee, Ok Joo

In contrast with a thermal plasma surgical instrument based on coagulative and ablative properties, low-temperature (non-thermal) non-equilibrium plasmas are known for novel medicinal effects on exposed tissue while minimizing undesirable tissue damage. In this study we demonstrated that arrays of non-thermal microplasma jet devices fabricated from a transparent polymer can efficiently inactivate fungi (Candida albicans) as well as bacteria (Escherichia coli), both in vitro and in vivo, and that

Several auto- or alloplastic dermal substitutes have been used for full thickness skin defects. However, there is no ideal dermal substitute that is biocompatible and offers adequate mechanical properties and sufficient thickness and volume. Silk fibroin can be considered a possible alternative material for the construction of dermal substitutes. Nanofibers fabricated by electrospinning silk fibroin were considered an excellent candidate due to their desirable biocompatibility. However, it is ge

Silk fibroin (SF) from silkworms has been widely studied as a biomaterial. The degradation behavior of silk biomaterials is important for medical applications, but few studies have examined long-term degradation behavior in vivo. In this study, we investigated the degradation behavior of SF membranes in vitro and in vivo. For the in vitro assay, we observed degradation of silk membranes in phosphate buffered saline, culture media, and an enzyme (proteinase K) solution. In the proteinase K soluti

Abstract Among various bioreactors used in the field of tissue engineering and regenerative medicine, a magnetic bioreactor is more capable of providing steady force to the cells while avoiding direct manipulation of the materials. However, most of them are complex and difficult to fabricate, with drawbacks in terms of consistency and biocompatibility. In this study, a magnetic bioreactor system and a magnetic hydrogel were manufactured by single-stage three-dimensional (3D) printing with digita

Silk is a natural macromolecular protein consisting of fibroin and sericin. Silk fibroin (SF), derived from Bombyx mori, is a representative fibrous protein that has been used mainly in fashion textiles and surgical sutures. Also, SF has been extensively applied as a potential biomaterial in a number of biomedical and biotechnological fields, as SF can be reconstituted in various forms through physical and chemical processes. In addition to direct use of SF with intrinsic structure and propertie

실크 피브로인과 poly(vinyl alcohol)(PVA)는 뛰어난 생체적합성과 수용성을 가져 생체의학 분야에서 주목하는 재료이다. 본 연구에서는 실크 피브로인과 PVA를 초음파와 동결/융해 방법으로 드레싱제로서 사용 가능한 하이드로젤을 제조하고자 하였다. 실크와 PVA를 100/0, 75/25, 50/50, 25/75, 0/100 비율로 혼합하였다. 제작한 하이드로젤을 FE-SEM, TGA, FTIR, 압축 강도 측정 등을 통해 물성을 분석하였다. 실크/PVA 하이드로젤은 PVA 함량이 증가할수록 공극 크기와 팽윤도는 감소하였으며, 젤의 강도는 증가하였다. PVA를 첨가함으로써 실크의 기계적 물성이 향상되는 것을 확인하였다. 본 연구에서 제조된 실크/PVA 하이드로젤은 드레싱제로서 사용 가능성을 제시하였다. Biomaterials like silk fibroin (SF) and poly(vinyl alcohol) (PVA) have received increasing attent

The trachea plays a critical role in maintaining airway patency, ventilation, and mucociliary clearance, supported by its unique anatomical and structural features. Tracheal defects resulting from congenital anomalies, malignancies, trauma, or prolonged intubation present significant clinical challenges. Traditional reconstruction methods, such as end-to-end anastomosis and patch grafts, are often limited by technical feasibility and suboptimal outcomes. Recently, tissue-engineered tracheal scaf

AI Hub [교육용 한국인의 다국어 음성 데이터]에 포함된 중국어 음성 데이터는 국내외적으로 가장 규모가 큰 비모어화자 중국어 음성 데이터 가운데 하나이다. 따라서 이는 언어학적 연구와 더불어 교육용 AI 데이터 구축, AI 음성 자동 인식과 실시간 통역, AI 기반 발음·말하기 자동 평가 모델 개발에 매우 중요한 활용 가치를 갖는다. 본 연구는 [교육용 한국인의 외국어 음성 데이터]의 중국어 음성 데이터의 구조와 특성을 소개, 평가하고, 더 나아가 발음 평가용 데이터의 라벨링 데이터(labeled data)를 활용하여 한국인 학습자의 중국어에 나타나는 자음 대체오류를 분석한 결과를 제공한다. 따라서 본 연구 결과는 향후 학습자 한국인의 중국어 음성 데이터 구축과 품질 평가 시 보완, 고려되어야 할 점을 구체적으로 제안하며, 발음 오류 분석을 위하여 대규모 음성 데이터를 활용하는 연구방법론을 제시한다.

This study examines the implementation of pitch cues in L2 (second language) speech by conducting an acoustic analysis of the global and local pitch cues in L1 (first language) Mandarin speakers’ L2 Korean. Results of the study show: (1) while the phonological patterns of AP (accentual phrase) and IP (intonational phrase) tones in L2 speech largely resemble those in L1 speech, the L2 production is characterized by the significantly lowered and reduced overall pitch range. (2) The L2 speakers ten

A large number of tone languages are distributed throughout Asia. However, despite an abundant amount of descriptive studies on tone inventories of individual languages in the region, our understanding of the characteristics of tones in Asian languages still remains limited due to the paucity of comparative research. Adopting phonological typology as a tool to measure the complexity of tone systems, this chapter presents quantitative analyses of tones collected from the cross-linguistic database