Lee, Zang Hee
Seoul National University · 生化学・遺伝学・分子生物学
研究室紹介
Professor Lee Zang He's research lab focuses on molecular mechanisms underlying bone metabolism and immune regulation, with a central emphasis on osteoclastogenesis, bone homeostasis, and the role of signaling pathways in pathological bone loss. The lab investigates key regulators such as RANKL, HDACs, and TRAF proteins, exploring their roles in osteoclast differentiation and apoptosis, as well as the immunomodulatory functions of acute-phase proteins like haptoglobin in bone remodeling. Using both in vitro and in vivo models, the lab aims to identify novel therapeutic targets for bone diseases such as osteoporosis, rheumatoid arthritis, and periodontal disease.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Excessive receptor activator of NF-kappaB ligand (RANKL) signaling causes enhanced osteoclast formation and bone resorption. Thus, down-regulation of RANKL expression or its downstream signals may be a therapeutic approach to the treatment of pathological bone loss. In this study, we investigated the effects of Trolox, a water-soluble vitamin E analogue, on osteoclastogenesis and RANKL signaling. Trolox potently inhibited interleukin-1-induced osteoclast formation in bone marrow cell-osteoblast
Histone deacetylases (HDACs) deacetylate both histones and nonhistone proteins and play a key role in the regulation of physiologic and aberrant gene expression. Inhibition of HDACs has emerged as a promising therapeutic target for cancer and neurologic diseases. In this study we investigated the osteogenic effect and mechanism of action of MS-275, a class I HDAC inhibitor with preference for HDAC1. Both local and systemic administration of MS-275 stimulated bone regeneration in animal models. M
Osteoclasts are multinucleated cells with the unique ability to resorb bone. Elevated activity of these cells under pathologic conditions leads to the progression of bone erosion that occurs in osteoporosis, periodontal disease, and rheumatoid arthritis. Thus, the regulation of osteoclast apoptosis is important for bone homeostasis. In this study, we examined the effects of the Janus tyrosine kinase 2 specific inhibitor AG490 on osteoclast apoptosis. We found that AG490 greatly inhibited osteocl