Sangho Lee
Sungkyunkwan University · 生化学・遺伝学・分子生物学
研究室紹介
Professor Sangho Lee's research lab focuses on molecular and cellular mechanisms underlying physiological and pathological processes, with key interests in protein conformational dynamics at interfaces, stress-induced reproductive toxicity, and the role of cellular machinery such as the ESCRT complex in intracellular trafficking and protein degradation. The lab also investigates systemic responses to disease models, including sepsis-induced hepatic dysfunction and genetic factors in endocrine disorders like hypoparathyroidism. Their work combines biochemical, molecular, and in vivo approaches to understand disease mechanisms and identify potential therapeutic targets.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15The conformational changes of whey proteins upon adsorption at the soy oil/water interface were investigated using Fourier transform infrared (FT-IR) spectroscopy. Significant changes were observed in the bands assigned to beta-sheets and alpha-helix structures following the adsorption of proteins at the oil/water interface. The remaining interfacial proteins after Tween 20 desorption revealed small changes in beta-sheet and alpha-helical structures, whereas in the desorbed whey proteins the uno
KRG protected immobilization stress-induced testicular damage and fertility factors in rats, thereby indicating its potential in the treatment of stress-related male sterility.
The effects of polymicrobial sepsis on the activity and gene expression of hepatic microsomal cytochrome P450 (CYP) were examined. Rats were subjected to polymicrobial sepsis by cecal ligation and puncture (CLP). Liver and blood samples were taken 2, 6, and 24 h after CLP. The serum aminotransferase levels and lipid peroxidation increased 24 h after CLP. The hepatic concentrations of reduced glutathione and total CYP content decreased 24 h after CLP. The CYP1A1 activity and its protein level dec