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Seung Mi Lee

Seoul National University · 医学

研究室紹介

Professor Seung Mi Lee's research lab focuses on maternal-fetal medicine and perinatal infectious diseases, with a strong emphasis on the diagnosis and clinical implications of preterm birth, intra-amniotic infection, and maternal-fetal transmission of pathogens. The lab investigates biomarkers such as Amnisure and fetal fibronectin to assess preterm labor and rupture of membranes, while also exploring the role of periodontopathogens and HPV in pregnancy outcomes. A key research direction involves understanding the timing, routes, and risks of vertical transmission of infections like HPV and genital mycoplasmas during pregnancy.

preterm birthintra-amniotic infectionvertical transmissionbiomarkers in pregnancyHPV in pregnancy

Research Overview

Papers
295
Total Citations
4,242
Papers (5y)
68
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
68total
2022
2023
2024
2025
2026
Citations per year (5y)
440total
20222023202420252026

Selected Papers

15
1
Article|153 citations·2009
The clinical significance of a positive Amnisure test™ in women with term labor with intact membranes
Seung Mi Lee, Joonho Lee, Hyo Suk Seong, Si Eun Lee, Joong Shin Park, Roberto Romero, Bo Hyun Yoon
SJR Q2The Journal of Maternal-Fetal & Neonatal MedicineOA

OBJECTIVE: The Amnisure ROM test is approved for the diagnosis of rupture of membranes (ROM). Yet, a fraction of patients with a positive test have intact membranes by sterile speculum examination. The objective of this study was to determine the clinical significance of this finding. METHODS: The study population consisted of four groups of nulliparous women at term: (1) not in labor without clinical evidence of ROM (n = 125); (2) in labor without clinical ROM with a negative Amnisure test (n =

EpidemiologyMedicine
2
Article|144 citations·2012
Effect of dry- and wet-milled rice flours on the quality attributes of gluten-free dough and noodles
Soojung Heo, Seung Mi Lee, Jae‐Hoon Shim, Sang‐Ho Yoo, Suyong Lee
SJR Q1Journal of Food Engineering
Nutrition and DieteticsNursing
3
Article|119 citations·2018
Non-alcoholic fatty liver disease in the first trimester and subsequent development of gestational diabetes mellitus
Seung Mi Lee, Soo Heon Kwak, Ja Nam Koo, Ig Hwan Oh, Jeong Eun Kwon, Byoung Jae Kim, Sun Min Kim, Sang Youn Kim, Gyoung Min Kim, Sae Kyung Joo, Bo Kyung Koo, Sue Shin
SJR Q1DiabetologiaOA
Obstetrics and GynecologyMedicine
4
Article|110 citations·2005
Prevalence of putative periodontopathogens in subgingival dental plaques from gingivitis lesions in Korean orthodontic patients.
Seung Mi Lee, So Young Yoo, Hwa-Sook Kim, Kwang‐Won Kim, Young-Joo Yoon, Sung‐Hoon Lim, Hee‐Young Shin, Joong‐Ki Kook
PubMed

The objective of this study was to detect and compare the presence of periodontopathogens in the subgingival plaques of gingivitis lesions in adults who wore fixed orthodontic appliances, as opposed to adults who did not wear any orthodontic appliances. Thirty-six individuals participated in this study. Nineteen of these subjects did not wear any orthodontic appliances, and these subjects comprised the control group. The other 17 individuals had been wearing fixed orthodontic appliances for at l

UrologyMedicine
5
Article|109 citations·2012
The clinical significance of a positive Amnisure test in women with preterm labor and intact membranes
Seung Mi Lee, Roberto Romero, Jeong Woo Park, Sun Min Kim, Chan‐Wook Park, Steven J. Korzeniewski, Tinnakorn Chaiworapongsa, Bo Hyun Yoon
SJR Q2The Journal of Maternal-Fetal & Neonatal MedicineOA

Objective: This study was conducted to examine the frequency and clinical significance of a positive Amnisure test in patients with preterm labor and intact membranes by sterile speculum exam. Study design: A retrospective cohort study was performed including 90 patients with preterm labor and intact membranes who underwent Amnisure tests prior to amniocentesis (< 72 h); most patients (n = 64) also underwent fetal fibronectin (fFN) tests. Amniotic fluid (AF) was cultured for aerobic/anaerobic ba

EpidemiologyMedicine
6
Article|92 citations·2013
Risk of Vertical Transmission of Human Papillomavirus throughout Pregnancy: A Prospective Study
Seung Mi Lee, Joong Shin Park, Joong Shin Park, Errol R. Norwitz, Ja Nam Koo, Ig Hwan Oh, Jeong Woo Park, Jeong Woo Park, Sun Min Kim, Yun Hwan Kim, Chan‐Wook Park, Yong Sang Song
SJR Q1PLoS ONEOA

OBJECTIVE: Much controversy still exists about maternal-to-infant transmission of human papillomavirus (HPV) infection, specifically about the magnitude of the risk and the route and timing of such vertical transmission. This prospective cohort study examines the risk of vertical transmission of maternal HPV in each trimester of pregnancy. STUDY DESIGN: One hundred fifty three healthy pregnant women were followed longitudinally throughout pregnancy and cervical swabs obtained in each trimester a

EpidemiologyMedicine
7
Article|78 citations·2010
The frequency and risk factors of funisitis and histologic chorioamnionitis in pregnant women at term who delivered after the spontaneous onset of labor
Seung Mi Lee, Roberto Romero, Kyung‐A Lee, Hye Jin Yang, Kyung Joon Oh, Chan‐Wook Park, Bo Hyun Yoon
SJR Q2The Journal of Maternal-Fetal & Neonatal Medicine

The longer the duration of labor, the higher the risk of funisitis and histologic chorioamnionitis in pregnant women at term who delivered after the spontaneous onset of labor.

EpidemiologyMedicine
8
Article|69 citations·2013
Acute Histologic Chorioamnionitis Is a Risk Factor for Adverse Neonatal Outcome in Late Preterm Birth after Preterm Premature Rupture of Membranes
Seung Mi Lee, Jeong Woo Park, Byoung Jae Kim, Chan‐Wook Park, Joong Shin Park, Jong Kwan Jun, Bo Hyun Yoon
SJR Q1PLoS ONEOA

BACKGROUND: The objective of this study was to determine whether acute histologic chorioamnionitis is associated with adverse neonatal outcomes in late preterm infants who were born after preterm PROM. METHODOLOGY/PRINCIPAL FINDINGS: The relationship between the presence of acute histologic chorioamnionitis and adverse neonatal outcome was examined in patients with preterm PROM who delivered singleton preterm newborns between 34 weeks and 36 6/7 weeks of gestation. Nonparametric statistics were

EpidemiologyMedicine
9
Article|68 citations·2011
(1–3)(1–6)‐β‐Glucan‐enriched materials from Lentinus edodes mushroom as a high‐fibre and low‐calorie flour substitute for baked foods
Ju-Young Kim, Seung Mi Lee, Seung Mi Lee, In Young Bae, Hyuk‐Gu Park, Hyeon Gyu Lee, Suyong Lee, Suyong Lee
SJR Q1Journal of the Science of Food and Agriculture

BACKGROUND: Extensive physiological and biological emphasis has been placed on pharmaceutical and medicinal uses of mushrooms containing β-glucans, but their incorporation into processed functional foods is quite limited. Thus, low-grade Lentinus edodes mushrooms were utilised to produce β-glucan-enriched materials (BGEMs), which were evaluated as a high-fibre and low-calorie substitute for wheat flour. RESULTS: The fractions obtained from Lentinus edodes mushrooms contained 514 g kg⁻¹ of (1-3)-

Plant ScienceAgricultural and Biological Sciences
10
Article|63 citations·2022
Long-term cardiovascular outcomes of gestational diabetes mellitus: a prospective UK Biobank study
Seung Mi Lee, Manu Shivakumar, Ji Won Park, Young Mi Jung, Eun Kyung Choe, Soo Heon Kwak, Sohee Oh, Joong Shin Park, Jong Kwan Jun, Dokyoon Kim, Jae‐Seung Yun
SJR Q1Cardiovascular DiabetologyOA

BACKGROUND: Previous studies showed that gestational diabetes mellitus (GDM) can be a risk factor for subsequent atherosclerotic cardiovascular disease. However, there is a paucity of information regarding diverse cardiovascular outcomes in elderly women after GDM. In the current study, we examined whether women with a history of GDM have an increased risk for long-term overall cardiovascular outcomes. METHODS: Among the UK participants, we included 219,330 women aged 40 to 69 years who reported

Obstetrics and GynecologyMedicine
11
Article|57 citations·2019
Nonalcoholic fatty liver disease is a risk factor for large-for-gestational-age birthweight
Seung Mi Lee, Byoung Jae Kim, Ja Nam Koo, Errol R. Norwitz, Ig Hwan Oh, Sun Min Kim, Sang Youn Kim, Gyoung Min Kim, Soo Heon Kwak, Won Kim, Sae Kyung Joo, Sue Shin
SJR Q1PLoS ONEOA

The presence of Grade 2-3 steatosis on ultrasound in early pregnancy was associated with the increased risk of delivering an LGA infant, even after adjustment for multiple confounding factors including GDM. Adiponectin may be the linking biomarker between NAFLD and LGA.

EpidemiologyMedicine
12
Article|53 citations·2012
Systemic inflammatory stimulation by microparticles derived from hypoxic trophoblast as a model for inflammatory response in preeclampsia
Seung Mi Lee, Roberto Romero, You Jeong Lee, In Sook Park, Chan‐Wook Park, Bo Hyun Yoon
SJR Q1American Journal of Obstetrics and GynecologyOA
Obstetrics and GynecologyMedicine
13
Article|53 citations·2011
The risk of intra-amniotic infection, inflammation and histologic chorioamnionitis in term pregnant women with intact membranes and labor
Seung Mi Lee, Kyung‐A Lee, Sun Min Kim, Chan‐Wook Park, Bo Hyun Yoon
SJR Q1Placenta
EpidemiologyMedicine
14
Article|46 citations·2021
Metabolic Dysfunction-Associated Fatty Liver Disease and Subsequent Development of Adverse Pregnancy Outcomes
Seung Mi Lee, Young Mi Jung, E. Choi, Soo Heon Kwak, Ja Nam Koo, Ig Hwan Oh, Byoung Jae Kim, Sun Min Kim, Sang Youn Kim, Gyoung Min Kim, Sae Kyung Joo, Bo Kyung Koo
SJR Q1Clinical Gastroenterology and HepatologyOA
EpidemiologyMedicine
15
Article|40 citations·2018
Inflammatory proteins in maternal plasma, cervicovaginal and amniotic fluids as predictors of intra-amniotic infection in preterm premature rupture of membranes
Seung Mi Lee, Kyo Hoon Park, Eun Young Jung, Song Yi Kook, Hyun-Soo Park, Se Jeong Jeon
SJR Q1PLoS ONEOA

The levels of inflammatory proteins in the CVF correlated with those in the AF, whereas those in the plasma showed no correlation. A non-invasive model using clinical factors and CVF cytokine levels predicted the risk of MIAC in women with pPROM.

EpidemiologyMedicine

Research Areas

EpidemiologyObstetrics and GynecologyPediatrics, Perinatology and Child HealthSurgeryPulmonary and Respiratory MedicineNutrition and Dietetics

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