Soo Hwan Oh
Korea University · 生化学・遺伝学・分子生物学
研究室紹介
Professor Soo Hwan Oh's research lab focuses on the molecular mechanisms underlying viral pathogenesis, autophagy, and cancer progression, with a particular emphasis on the roles of host and viral factors in immune evasion and disease persistence. The lab investigates how autophagy-related proteins such as UVRAG contribute to both tumor suppression and viral entry, revealing unexpected non-canonical functions beyond canonical autophagy. By integrating genomics, epigenomics, and functional virology approaches, the lab uncovers novel regulatory nodes in cancer metabolism and antiviral defense, especially in the context of persistent gamma-herpesvirus infections and chemotherapy resistance. Their work bridges fundamental cell biology with translational applications in oncology and virology.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Autophagy-related factors are implicated in metabolic adaptation and cancer metastasis. However, the role of autophagy factors in cancer progression and their effect in treatment response remain largely elusive. Recent studies have shown that UVRAG, a key autophagic tumour suppressor, is mutated in common human cancers. Here we demonstrate that the cancer-related UVRAG frameshift (FS), which does not result in a null mutation, is expressed as a truncated UVRAG(FS) in colorectal cancer (CRC) with
Gamma-herpesviruses (gammaHVs) have developed an interaction with their hosts wherein they establish a life-long persistent infection and are associated with the onset of various malignancies. One critical virulence factor involved in the persistency of murine gamma-herpesvirus 68 (gammaHV68) is the viral homolog of the Bcl-2 protein (vBcl-2), which has been implicated to counteract both host apoptotic responses and autophagy pathway. However, the relative significance of the two activities of v
Understanding the mechanisms by which compounds discovered using cell-based phenotypic screening strategies might exert their effects would be highly augmented by new approaches exploring their potential interactions with the genome. For example, altered androgen receptor (AR) transcriptional programs, including castration resistance and subsequent chromosomal translocations, play key roles in prostate cancer pathological progression, making the quest for identification of new therapeutic agents
Although often located at a distance from their target gene promoters, enhancers are the primary genomic determinants of temporal and spatial transcriptional specificity in metazoans. Since the discovery of the first enhancer element in simian virus 40, there has been substantial interest in unraveling the mechanism(s) by which enhancers communicate with their partner promoters to ensure proper gene expression. These research efforts have benefited considerably from the application of increasing
Cisplatin is an antineoplastic drug administered at suboptimal and intermittent doses to avoid life-threatening effects. Although this regimen shortly improves symptoms in the short term, it also leads to more malignant disease in the long term. We describe a multilayered analysis ranging from chromatin to translation-integrating chromatin immunoprecipitation sequencing (ChIP-seq), global run-on sequencing (GRO-seq), RNA sequencing (RNA-seq), and ribosome profiling-to understand how cisplatin co