Suk-Jae Jeong
Seoul National University · 医学
研究室紹介
Professor Suk-Jae Jeong's research lab specializes in pharmaceutical sciences with a focus on drug disposition, transport mechanisms, and pharmacokinetic modeling. The lab investigates the role of drug transporters—particularly ABC transporters like BCRP—in drug efficacy and toxicity, and develops advanced analytical methods for drug quantification and particulate contamination control. Using integrated approaches combining in vitro, in vivo, and physiologically based pharmacokinetic (PBPK) modeling, the lab aims to predict and optimize drug interactions and tissue distribution, especially for centrally acting drugs delivered via non-invasive routes such as nasal administration. The research also extends to novel drug delivery systems and the development of robust bioanalytical methods for clinical and preclinical applications.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15The potential inhibitory effect of quercetin, a major plant flavonol, on breast cancer resistance protein (BCRP) activity was investigated in this study. The presence of quercetin significantly increased the cellular accumulation and associated cytotoxicity of the BCRP substrate mitoxantrone in human cervical cancer cells (HeLa cells) in a concentration-dependent manner. The transcellular efflux of prazosin, a stereotypical BCRP substrate, was also significantly reduced in the presence of querce
Fexuprazan is a new drug candidate in the potassium-competitive acid blocker (P-CAB) family. As proton pump inhibitors (PPIs), P-CABs inhibit gastric acid secretion and can be used to treat gastric acid-related disorders such as gastroesophageal reflux disease (GERD). Physiologically based pharmacokinetic (PBPK) models predict drug interactions as pharmacokinetic profiles in biological matrices can be mechanistically simulated. Here, we propose an optimized and validated PBPK model for fexupraza
The objectives of this study were to evaluate the relative contribution of the direct pathway in overall brain transport for 17 model drugs with different physicochemical properties after nasal administrations and to identify factors that govern the fraction of the dose transported to the brain via the direct pathway (F(a, direct)). When the model drugs were nasally administered to rats, 5 of the 17 model drugs were delivered to a significant extent to the brain via the direct pathway. Multiple
A single-dose glass ampoule was developed for ease of administration. When glass ampoules are opened, resulting in contamination by particulate matter. Reducing its contamination may minimize the risk in patients due to particulates. This study reports on an attempt to reduce insoluble particulate contamination by developing methods for the precise measurement of this. A vacuum machine (VM) was used to reduce the level of insoluble particulate contamination, and a microscopy, scanning electron m
A liquid chromatography-mass spectrometry (LC-MS) assay was developed and validated for the quantification of cilnidipine, a calcium channel antagonist, in human plasma. Plasma samples were processed by liquid-liquid extraction and the analyte, along with nimodipine (an internal standard), and analyzed using selected ion monitoring (SIM) for detection. The absolute extraction recovery was determined to be not less than 89.1% for various concentrations. The detector response was specific and line