Sung Ah Jang
Sungkyunkwan University · 医学
研究室紹介
Professor Sung Ah Jang's research lab specializes in cardiovascular regeneration and pericardial disease, focusing on stem cell therapy for acute myocardial infarction, cardiac remodeling in hypertension, and the pathophysiology of pericardial disorders such as constrictive pericarditis. The lab employs advanced imaging techniques like 18F-FDG-PET/CT and speckle tracking echocardiography to investigate inflammation, fibrosis, and functional changes in the heart. Key research directions include the role of the pericardium in ventricular mechanics, the protective effects of statins and ARBs in cardiac remodeling, and the differential diagnosis of complex pericardial diseases using molecular imaging. The lab integrates preclinical models with clinical translation to develop novel therapeutic strategies for heart failure with preserved ejection fraction and cardiomyopathy.
Research Overview
Research Output Trend
Figures are computed from collected data and may differ slightly.
Selected Papers
15Stem cell transplantation in acute myocardial infarction (AMI) has emerged as a promising therapeutic option. We evaluated the impact of AMI on mesenchymal stem cell (MSC) differentiation into cardiomyocyte lineage. Cord blood-derived human MSCs were exposed to in vitro conditions simulating in vivo environments of the beating heart with acute ischemia, as follows: (a) myocardial proteins or serum obtained from sham-operated rats, and (b) myocardial proteins or serum from AMI rats, with or witho
Hypertensive patients with left ventricular hypertrophy (LVH) are the most common high-risk group to develop heart failure with preserved ejection fraction. Recent reports have noted the favorable effect of statins on LVH. We evaluated the effect of rosuvastatin on cardiac remodeling, function, and progression to heart failure in a hypertensive rat model with established LVH. Dahl salt-sensitive rats were fed a high-salt diet until 13 weeks of age. After LVH was confirmed by echocardiography, ra
BACKGROUND: The role of pericardium in left ventricular (LV) twist has not been directly investigated. We sought to determine the role of pericardium in maintenance of LV twist function in an animal experiment, before and after pericardial opening. METHODS: 13 mongrel dogs were initially operated on, but two dogs were excluded from the final analyses owing to poor speckle tracking. Intraoperative echocardiography for conventional and speckle tracking measurements was performed at baseline with i
Abstract This study aimed to assess the role of 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography ( 18 FDG-PET/CT) in the differential diagnosis of pericardial disease. The diagnosis is often troublesome because pericardial fluid analysis or biopsy does not always provide answers. 18 FDG-PET/CT can visualize both inflammation and malignancy and offers a whole-body assessment. Patients who visited the Pericardial Disease Clinic of Samsung Medical Center with an 18 FDG-PET/C
Constrictive pericarditis is a disease of the pericardium resulting from chronic inflammation and/or scar responsible for a clinical feature of left and right ventricular failure. Although constrictive pericarditis has long been considered a surgical disease, a subset of patients experience reversibility of pericardial inflammation, a condition referred to as "transient constriction." Thus, after establishing the diagnosis of constrictive pericarditis, it is essential to evaluate the duration an
Angiotensin receptor blockers (ARBs) have organ-protective effects in heart failure and may be also effective in doxorubicin-induced cardiomyopathy (DOX-CMP); however, the efficacy of ARBs on the prevention of DOX-CMP have not been investigated. We performed a preclinical experiment to evaluate the preventive effect of a novel ARB, fimasartan, in DOX-CMP. All animals underwent echocardiography and were randomly assigned into three groups: treated daily with vehicle (DOX-only group, n=22), 5 mg/k