Woo Yong Lee
Yonsei University · 材料科学
研究室紹介
Professor Woo Yong Lee's research lab specializes in the development of advanced electrochemical and biosensing platforms for biomedical diagnostics, with a strong focus on sensitive and selective detection of rare biological entities such as circulating tumor cells (CTCs). The lab integrates nanomaterials, electrogenerated chemiluminescence (ECL), and microfluidic technologies to create highly sensitive, stable, and automated biosensors for clinical applications. Key research directions include the design of functionalized nanomaterials—such as Nafion-stabilized magnetic nanoparticles and gold nanoparticles—for signal amplification and efficient cell isolation, as well as innovative microfluidic systems for high-purity CTC enrichment from whole blood. The lab's work bridges materials science, electrochemistry, and biomedical engineering to enable point-of-care diagnostics and personalized medicine.
Research Overview
Research Output Trend
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Selected Papers
15Electrochemical behavior and electrogenerated chemiluminescence (ECL) of tris(2,2'-bipyridyl)ruthenium(II) (Ru(bpy)3(2+)) immobilized in sol-gel-derived titania TiO2)-Nafion composite films coated on a glassy carbon electrode have been investigated. The electroactivity of Ru(bpy)3(2+) ion exchanged into the composite films and its ECL behavior were strongly dependent upon the amount of Nafion incorporated into the TiO2-Nafion composite films. The ECL sensor of Ru(bpy)32+ immobilized in a TiO2-Na
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEvaluation of Use of Tris(2,2'-bipyridyl)ruthenium(III) as a Chemiluminescent Reagent for Quantitation in Flowing StreamsWon-Yong. Lee and Timothy A. NiemanCite this: Anal. Chem. 1995, 67, 11, 1789–1796Publication Date (Print):June 1, 1995Publication History Published online1 May 2002Published inissue 1 June 1995https://pubs.acs.org/doi/10.1021/ac00107a007https://doi.org/10.1021/ac00107a007research-articleACS PublicationsRequest reuse permissionsArticl
Isolation of circulating tumor cells (CTCs) by size exclusion can yield poor purity and low recovery rates, due to large variations in size of CTCs, which may overlap with leukocytes and render size-based filtration methods unreliable. This report presents a very sensitive, selective, fast, and novel method for isolation and detection of CTCs. Our assay platform consists of three steps: (i) capturing CTCs with anti-EpCAM conjugated microbeads, (ii) removal of unwanted hematologic cells (e.g., le
A highly sensitive and stable [Ru(bpy)3]2+ ECL sensor has been fabricated based on the multilayer films of Nafion-stabilized magnetic nanoparticles (Nafion/Fe3O4) formed on a platinum electrode surface by means of an external magnet.
A highly sensitive microgravimetric lectin biosensor has been developed using carbohydrate-stabilized Au nanoparticles as a signal amplifier; mannose-stabilized Au nanoparticles formed a sandwich-type complex with the target Con A specifically bound to a mannose-modified Au QCM electrode to give an amplified frequency response.
Full automation with high purity for circulating tumor cell (CTC) isolation has been regarded as a key goal to make CTC analysis a "bench-to-bedside" technology. Here, we have developed a novel centrifugal microfluidic platform that can isolate the rare cells from a large volume of whole blood. To isolate CTCs from whole blood, we introduce a disc device having the biggest sample capacity as well as manipulating blood cells for the first time. The fully automated disc platform could handle 5 mL
Abstract Novel, low‐voltage, high‐detectivity, solution‐processed, flexible near‐infrared (NIR) photodetectors for optoelectronic applications are realized and their optoelectronic properties are investigated for the first time. This is achieved by synthesizing Ag 2 Se nanoparticles (NPs) in aqueous solutions, and depositing highly crystalline Ag 2 Se thin films at 150 °C with redistributed Ag 2 Se NPs in aqueous inks. The high conductivity and low trap concentration of the 150 °C annealed Ag 2