Yoon‐Jin Lee

Fungal infections are a major contributor to infectious disease-related deaths across the globe. Candida species are among the most common causes of invasive mycotic disease, with Candida albicans reigning as the leading cause of invasive candidiasis. Given that fungi are eukaryotes like their human host, the number of unique molecular targets that can be exploited for antifungal development remains limited. Currently, there are only three major classes of drugs approved for the treatment of inv

Abstract Fungal pathogens are a severe public health problem. The leading causative agents of systemic fungal infections include species from the Candida , Cryptococcus , and Aspergillus genera. As opportunistic pathogens, these fungi are generally harmless in healthy hosts; however, they can cause significant morbidity and mortality in immunocompromised patients. Despite the profound impact of pathogenic fungi on global human health, the current antifungal armamentarium is limited to only three

We describe a GPU-based algorithm for rendering a 3D model as a line drawing, based on the insight that a line drawing can be understood as an abstraction of a shaded image. We thus render lines along tone boundaries or thin dark areas in the shaded image. We extend this notion to the dual: we render highlight lines along thin bright areas and tone boundaries. We combine the lines with toon shading to capture broad regions of tone.

We describe a GPU-based algorithm for rendering a 3D model as a line drawing, based on the insight that a line drawing can be understood as an abstraction of a shaded image. We thus render lines along tone boundaries or thin dark areas in the shaded image. We extend this notion to the dual: we render highlight lines along thin bright areas and tone boundaries. We combine the lines with toon shading to capture broad regions of tone. The resulting line drawings effectively convey both shape and ma

Mesh partitioning and parts extraction have become key ingredients for many mesh manipulation applications both manual and automatic. In this paper, we present an intelligent scissoring operator for meshes which supports both automatic segmentation and manual cutting. Instead of segmenting the mesh by clustering, our approach concentrates on finding and defining the contours for cutting. This approach is based on the minima rule, which states that human perception usually divides a surface into

Individuals with autism spectrum disorder (ASD) have altered gut microbiota, which appears to regulate ASD symptoms via gut microbiota-brain interactions. Rapid assessment of gut microbiota profiles in ASD individuals in varying physiological contexts is important to understanding the role of the microbiota in regulating ASD symptoms. Microbiomes secrete extracellular membrane vesicles (EVs) to communicate with host cells and secreted EVs are widely distributed throughout the body including the

본 연구는 50세 이상의 은퇴자들을 대상으로 은퇴자의 삶의 만족도의 영향요인 중 주관적 건강인식과 삶의 만족도의 관계를 살펴보고, 경제적 노후준비가 주관적 건강과 더불어 삶의 만족도에 미치는 영향을 함께 분석하여, 은퇴자들의 삶의 만족도를 향상시키고 건강한 노후준비를 위한 정책적․실천적 방안을 마련하는데 목적이 있다. 이러한 목적에 따라 본 연구는 국민노후보장패널 4차 본조사(2011) 자료에 대해 stata 11.0 및 sas 9.1 프로그램을 이용하여 주관적 건강인식과 삶의 만족도와의 관계 및 경제적 노후준비의 조절효과를 검증하기 위한 다중회귀분석(Multi Regression Analysis)을 실시하였다. 그 결과 첫째, 은퇴자의 주관적 건강인식은 삶의 만족도에 정적으로 유의하게 나타났으며, 둘째, 주관적 건강인식과 삶의 만족도와의 관계에서의 경제적 노후준비가 조절효과를 미치는 것으로 나타났다. 이와 같은 분석결과는 은퇴 이후의 건강인식과 건강관리의 중요성을 제시하고 있고,

PURPOSE: To investigate the characteristics of eyes with dry eye disease (DED) whose lipid layer thickness (LLT) measured 100 nm on a LipiView II interferometer and compare the DED parameters of them to those with LLT below 100 nm. METHODS: A total of 201 eyes of 102 enrolled DED patients (mean age 56.4 ± 11.8 years) were classified into 3 groups according to their average LLT; < 60 nm as thin-LLT (n = 49), 60-99 nm as normal-LLT (n = 77), and 100 nm as thick-LLT (n = 75). LLT, meiboscore, Schir

A number of specific genetic variants including gene mutations and single nucleotide variations have been identified in genomewide association studies of autism spectrum disorder (ASD).ASD phenotypes in individuals carrying specific genetic variations are manifest mostly in a heterozygous state.Furthermore, individuals with most genetic variants show incomplete penetrance and phenotypic variability, suggesting that non-genetic factors are also involved in developing ASD.However, the mechanisms o

우리나라 산재보험 제도에서 재활서비스 영역은 산재근로자의 특성을 고려하여 발전을 거듭하여왔다. 특히 2001년의 재활사업 5개년 계획 수립 이후 산재근로자의 직업 복귀율은 점차 향상하고 있다. 하지만 재활서비스 영역의 양적 증가 및 수치화된 직업 복귀율이 실질적인 재활서비스의 발전과 직업복귀의 지속적인 성공을 담보한다고는 할 수 없다. 이에 본 연구는 기존에 거의 다루어지지 않았던 변수인 산재근로자들의 재활서비스 이용에의 필요성 인식, 즉 이용 욕구가 성공적인 직업복귀에 영향을 미치는가에 대한 분석을 통해 현재의 산재보험 재활서비스가 개별적인 산재근로자들의 이용 욕구에 부응하여 운영되고 있는가를 직업 복귀 이후의 직장에서의 생활을 고려한 ‘성공적인 직업복귀’의 측면에서 살펴봄으로써 재활서비스와 직업복귀의 질적 향상을 도모하고자 한다. 본 연구는 제1차 산재보험패널(PSWCI) 데이터를 이용하여 직업복귀를 한 사람들을 대상으로 성공적인 직업복귀에 재활서비스 이용 욕구가 영향을 미치는