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Young-Hoon Song

Seoul National University · 農学・生物学

研究室紹介

Professor Young-Hoon Song's research lab focuses on the molecular mechanisms underlying photoperiodic flowering regulation in higher plants, particularly in model species like Arabidopsis and major cereal crops such as rice, wheat, and barley. The lab investigates how circadian clock components, FKF1, GI, ZTL, and CO proteins integrate light and time signals to precisely control the expression of florigen (FT) and initiate flowering. A central theme is the post-translational regulation of key transcription factors like CO and HY5, including their protein-protein interactions, stability, and DNA-binding dynamics under varying photoperiods. The lab also explores the evolutionary conservation of these pathways in legumes, such as soybean, through functional characterization of homologous transcription factors like STF1.

photoperiodismflorigencircadian clockflowering timeCO protein stability

Research Overview

Papers
85
Total Citations
4,474
Papers (5y)
26
Primary Field
農学・生物学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
26total
2022
2023
2024
2025
2026
Citations per year (5y)
295total
20222023202420252026

Selected Papers

15
1
Review|771 citations·2014
Photoperiodic Flowering: Time Measurement Mechanisms in Leaves
Young Hun Song, Jae Sung Shim, Hannah Kinmonth‐Schultz, Takato Imaizumi
SJR Q1Annual Review of Plant BiologyOA

Many plants use information about changing day length (photoperiod) to align their flowering time with seasonal changes to increase reproductive success. A mechanism for photoperiodic time measurement is present in leaves, and the day-length-specific induction of the FLOWERING LOCUS T (FT) gene, which encodes florigen, is a major final output of the pathway. Here, we summarize the current understanding of the molecular mechanisms by which photoperiodic information is perceived in order to trigge

Plant ScienceAgricultural and Biological Sciences
2
Review|676 citations·2013
Flowering time regulation: photoperiod- and temperature-sensing in leaves
Young Hun Song, Shogo Ito, Takato Imaizumi
SJR Q1Trends in Plant ScienceOA
Plant ScienceAgricultural and Biological Sciences
3
Article|485 citations·2012
FKF1 Conveys Timing Information for CONSTANS Stabilization in Photoperiodic Flowering
Young Hun Song, Robert W. Smith, Benjamin J. To, Andrew J. Millar, Takato Imaizumi
SJR Q1ScienceOA

Plants use day-length information to coordinate flowering time with the appropriate season to maximize reproduction. In Arabidopsis, the long day-specific expression of CONSTANS (CO) protein is crucial for flowering induction. Although light signaling regulates CO protein stability, the mechanism by which CO is stabilized in the long-day afternoon has remained elusive. Here, we demonstrate that FLAVIN-BINDING, KELCH REPEAT, F-BOX 1 (FKF1) protein stabilizes CO protein in the afternoon in long da

Plant ScienceAgricultural and Biological Sciences
4
Review|191 citations·2010
Similarities in the circadian clock and photoperiodism in plants
Young Hun Song, Shogo Ito, Takato Imaizumi
SJR Q1Current Opinion in Plant BiologyOA
Plant ScienceAgricultural and Biological Sciences
5
Article|190 citations·2018
Molecular basis of flowering under natural long-day conditions in Arabidopsis
Young Hun Song, Akane Kubota, Michael S. Kwon, Michael F. Covington, Nayoung Lee, Ella Taagen, Dianne Laboy Cintrón, Dae Yeon Hwang, Reiko Akiyama, Sarah K. Hodge, He Huang, Nhu Nguyen
SJR Q1Nature PlantsOA
Plant ScienceAgricultural and Biological Sciences
6
Article|184 citations·2014
Distinct roles of FKF1, GIGANTEA, and ZEITLUPE proteins in the regulation of CONSTANS stability in Arabidopsis photoperiodic flowering
Young Hun Song, Daniel A. Estrada, Richard S. Johnson, Somi K. Kim, Sang Yeol Lee, Michael J. MacCoss, Takato Imaizumi
SJR Q1Proceedings of the National Academy of SciencesOA

Many plants measure changes in day length to synchronize their flowering time with appropriate seasons for maximum reproductive success. In Arabidopsis, the day-length-dependent regulation of Constans (CO) protein stability is crucial to induce flowering locus T (FT) expression for flowering in long days. The flavin-binding, KELCH repeat, F-box1 (FKF1) protein binds to CO protein specifically in the long-day afternoon and stabilizes it, although the mechanism remains unknown. Here we demonstrate

Plant ScienceAgricultural and Biological Sciences
7
Article|85 citations·2008
DNA-Binding Study Identifies C-Box and Hybrid C/G-Box or C/A-Box Motifs as High-Affinity Binding Sites for STF1 and LONG HYPOCOTYL5 Proteins
Young Hun Song, Cheol Min Yoo, An Hong, Seong Hee Kim, Hee Jeong Jeong, Su Young Shin, Hye Jin Kim, Dae‐Jin Yun, Chae Oh Lim, Jeong Dong Bahk, Sang Yeol Lee, Ron T. Nagao
SJR Q1PLANT PHYSIOLOGYOA

LONG HYPOCOTYL5 (HY5) is a bZIP (basic leucine zipper) transcription factor that activates photomorphogenesis and root development in Arabidopsis (Arabidopsis thaliana). Previously, STF1 (soybean [Glycine max] TGACG-motif binding factor 1), a homologous legume protein with a RING-finger motif and a bZIP domain, was reported in soybean. To investigate the role of STF1, the phenotypes of transgenic Arabidopsis plants overexpressing STF1 and HY5 were compared. In addition, the DNA-binding propertie

Plant ScienceAgricultural and Biological Sciences
8
Article|80 citations·2011
CONSTANS and ASYMMETRIC LEAVES 1 complex is involved in the induction of FLOWERING LOCUS T in photoperiodic flowering in Arabidopsis
Young Hun Song, Ilha Lee, Sang Yeol Lee, Takato Imaizumi, Jong Chan Hong
SJR Q1The Plant JournalOA

Plants monitor changes in day length to coordinate flowering with favorable seasons to increase their fitness. The day-length specific induction of FLOWERING LOCUS T (FT) regulated by CONSTANS (CO) is the crucial aspect of photoperiodic flowering in Arabidopsis thaliana. Recent studies have elucidated some mechanisms of CO-dependent FT induction. Here, we demonstrate another mechanism of CO-dependent FT regulation. Our results indicate that CO protein partially regulates FT transcription by form

Plant ScienceAgricultural and Biological Sciences
9
Article|49 citations·2014
테러리즘과 난민문제의 안보화: 케냐의 난민정책을 중심으로
송영훈

이 연구는 난민의 대량이주를 둘러싼 국제사회의 인도주의와 난민 수용국의 난민정책과의 갈등을 분석하고 있다. 사하라이남 아프리카 국가들 중에서 난민 수용에 가장 적극적이었던 케냐 정부가 소말리아 난민의 유입에 대응하는 난민정책을 중심으로 난민정책의 안보화 현상을 설명하고 있다. 즉 케냐 정부는 자국 내에서 발생하는 테러로 인하여 국내에 거주하는 소말리아 난민들의 문제를 인도주의에 따른 지원을 통해 해결하려는 정책보다는 점차 소말리아 난민들이 국가안보를 위협하는 요인으로 인식하는 안보우선 정책을 채택하고 있다. 케냐정부가 난민문제를 안보화하면서 전 세계에서 가장 오래되고 가장 큰 난민캠프인 다다브 캠프에 거주하는 소말리아 난민을 송환시키기 위해 케냐 정부는 소말리아 정부와 난민송환협정을 2013년에 맺었다. 2011년 이후 알샤바브에 의해 빈번하게 발생하는 테러로 인하여 케냐 정부가 소말리아 난민의 대량 유입을 안보의 문제로 삼고 난민캠프를 폐쇄하고자 하는 것이다. 케냐 정부에 의한 난

10
Article|43 citations·2008
Isolation of CONSTANS as a TGA4/OBF4 interacting protein.
Young Hun Song, Na Song, Su Young Shin, Hye Jin Kim, Dae‐Jin Yun, Chae Oh Lim, Sang Yeol Lee, Kyu Young Kang, Jong Chan Hong
PubMed

Members of the TGA family of basic domain/leucine zipper transcription factors regulate defense genes through physical interaction with NON-EXPRESSOR OF PR1 (NPR1). Of the seven TGA family members, TGA4/octopine synthase (ocs)-element-binding factor 4 (OBF4) is the least understood. Here we present evidence for a novel function of OBF4 as a regulator of flowering. We identified CONSTANS (CO), a positive regulator of floral induction, as an OBF4-interacting protein, in a yeast two-hybrid library

Plant ScienceAgricultural and Biological Sciences
11
Review|37 citations·2023
Genes and Regulatory Mechanisms for Ginsenoside Biosynthesis
Padmanaban Mohanan, Tae‐Jin Yang, Young Hun Song
SJR Q2Journal of Plant BiologyOA
Molecular BiologyBiochemistry, Genetics and Molecular Biology
12
Review|20 citations·2016
The Effect of Fluctuations in Photoperiod and Ambient Temperature on the Timing of Flowering: Time to Move on Natural Environmental Conditions
Young Hun Song
SJR Q1Molecules and CellsOA

Plants have become physiologically adapted to a seasonally shifting environment by evolving many sensory mechanisms. Seasonal flowering is a good example of adaptation to local environmental demands and is crucial for maximizing reproductive fitness. Photoperiod and temperature are major environmental stimuli that control flowering through expression of a floral inducer, FLOWERING LOCUS T (FT) protein. Recent discoveries made using the model plant <i>Arabidopsis thaliana</i> have shown that the

Plant ScienceAgricultural and Biological Sciences
13
Article|12 citations·2024
Disrupting FKF1 homodimerization increases FT transcript levels in the evening by enhancing CO stabilization
Sung Won Cho, Jameela Lokhandwala, J. Park, Hye Won Kang, Mingi Choi, Hong‐Quan Yang, Takato Imaizumi, Brian D. Zoltowski, Young Hun Song
SJR Q1Plant Cell ReportsOA

KEY MESSAGE: FKF1 dimerization is crucial for proper FT levels to fine-tune flowering time. Attenuating FKF1 homodimerization increased CO abundance by enhancing its COP1 binding, thereby accelerating flowering under long days. In Arabidopsis (Arabidopsis thaliana), the blue-light photoreceptor FKF1 (FLAVIN-BINDING, KELCH REPEAT, F-BOX 1) plays a key role in inducing the expression of FLOWERING LOCUS T (FT), encoding the main florigenic signal in plants, in the late afternoon under long-day cond

Endocrine and Autonomic SystemsNeuroscience
14
Article|11 citations·2023
Low temperature‐mediated repression and far‐red light‐mediated induction determine morning FLOWERING LOCUS T expression levels
H. Kim, Hye Won Kang, Dae Yeon Hwang, Nayoung Lee, Akane Kubota, Takato Imaizumi, Young Hun Song
SJR Q1Journal of Integrative Plant BiologyOA

In order to flower in the appropriate season, plants monitor light and temperature changes and alter downstream pathways that regulate florigen genes such as Arabidopsis (Arabidopsis thaliana) FLOWERING LOCUS T (FT). In Arabidopsis, FT messenger RNA levels peak in the morning and evening under natural long-day conditions (LDs). However, the regulatory mechanisms governing morning FT induction remain poorly understood. The morning FT peak is absent in typical laboratory LDs characterized by high

Plant ScienceAgricultural and Biological Sciences
15
Article|10 citations·2023
Effect of far-red light on the production and diversity of ginsenosides in leaves of Panax ginseng Meyer
Padmanaban Mohanan, Tae‐Jin Yang, Young Hun Song
SJR Q2Applied Biological ChemistryOA

Abstract Ginsenosides are the most valuable and pharmacologically active triterpenoid saponins found in Panax ginseng . Although light quality affects ginsenoside content, little is known about the underlying genetic and regulatory mechanisms. Additionally, the correlation between the adaptability of ginseng to shade and ginsenoside biosynthesis remains poorly understood. In the present study, transcriptome analysis of ginseng seedlings using RNA sequencing revealed that the expression of ginsen

Molecular BiologyBiochemistry, Genetics and Molecular Biology

Research Areas

Plant ScienceMolecular BiologyControl and Systems EngineeringEndocrine and Autonomic SystemsMarketingGlobal and Planetary Change

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