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Young Jun Chai

Seoul National University · 医学

研究室紹介

Professor Young Jun Chai's research lab specializes in minimally invasive and endoscopic surgical techniques, particularly in thyroid and adrenal surgery, with a focus on improving patient outcomes through scarless or remote-access approaches such as transoral endoscopic thyroidectomy and retroperitoneal adrenalectomy. The lab also integrates advanced imaging and artificial intelligence to enhance diagnostic accuracy in thyroid nodules, leveraging deep learning models for non-invasive prediction of benign and malignant conditions. Additionally, the lab investigates molecular markers, such as SLC2A genes, to understand their prognostic significance in colorectal and thyroid cancers.

endoscopic surgerythyroid cancerartificial intelligence in medicineadrenalectomymolecular prognosis

Research Overview

Papers
243
Total Citations
4,262
Papers (5y)
87
Primary Field
医学

Research Output Trend

Figures are computed from collected data and may differ slightly.

Publications per year (5y)
87total
2022
2023
2024
2025
2026
Citations per year (5y)
374total
20222023202420252026

Selected Papers

15
1
Article|101 citations·2017
Transoral endoscopic thyroidectomy for papillary thyroid microcarcinoma: initial experience of a single surgeon
Young Jun Chai, Jung Kee Chung, Angkoon Anuwong, Gianlorenzo Dionigi, Hoon Yub Kim, Ki‐Tae Hwang, Seung Chul Heo, Ka Hee Yi, Kyu Eun Lee
SJR Q2Annals of Surgical Treatment and ResearchOA

TOET was feasible and could be performed safely for PTMC. TOET might become a new treatment option for the patients who do not want to leave visible scars on the body.

SurgeryMedicine
2
Article|97 citations·2016
Upregulation of SLC2 (GLUT) family genes is related to poor survival outcomes in papillary thyroid carcinoma: Analysis of data from The Cancer Genome Atlas
Young Jun Chai, Jin Wook Yi, So Won Oh, Young A Kim, Ka Hee Yi, Ju Han Kim, Kyu Eun Lee
SJR Q1Surgery
Endocrinology, Diabetes and MetabolismMedicine
3
Article|93 citations·2019
Ultrasound image analysis using deep learning algorithm for the diagnosis of thyroid nodules
Junho Song, Young Jun Chai, Hiroo Masuoka, Sun‐Won Park, Su‐jin Kim, June Young Choi, Hyoun‐Joong Kong, Kyu Eun Lee, Joongseek Lee, Nojun Kwak, Ka Hee Yi, Akira Miyauchi
SJR Q3MedicineOA

Fine needle aspiration (FNA) is the procedure of choice for evaluating thyroid nodules. It is indicated for nodules >2 cm, even in cases of very low suspicion of malignancy. FNA has associated risks and expenses. In this study, we developed an image analysis model using a deep learning algorithm and evaluated if the algorithm could predict thyroid nodules with benign FNA results.Ultrasonographic images of thyroid nodules with cytologic or histologic results were retrospectively collected. For al

Endocrinology, Diabetes and MetabolismMedicine
4
Review|78 citations·2014
Systematic Review of Surgical Approaches for Adrenal Tumors: Lateral Transperitoneal versus Posterior Retroperitoneal and Laparoscopic versus Robotic Adrenalectomy
Young Jun Chai, Hyungju Kwon, Hyeong Won Yu, Su‐jin Kim, June Young Choi, Kyu Eun Lee, Yeo‐Kyu Youn
SJR Q3International Journal of EndocrinologyOA

Background. Laparoscopic lateral transperitoneal adrenalectomy (LTA) has been the standard method for resecting benign adrenal gland tumors. Recently, however, laparoscopic posterior retroperitoneal adrenalectomy (PRA) has been more popular as an alternative method. This systematic review evaluates current evidence on adrenalectomy techniques, comparing laparoscopic LTA with PRA and laparoscopic adrenalectomy with robotic adrenalectomy. Methods. PubMed, Embase, and ISI Web of Knowledge databases

SurgeryMedicine
5
Article|76 citations·2019
Upregulation of SLC2A3 gene and prognosis in colorectal carcinoma: analysis of TCGA data
Eun‐Young Kim, Sohee Jung, Won Seo Park, Joon‐Hyop Lee, Rumi Shin, Seung Chul Heo, Eun Kyung Choe, Jae‐Hyun Lee, Kwangsoo Kim, Young Jun Chai
SJR Q2BMC CancerOA

BACKGROUND: Upregulation of SLC2A genes that encode glucose transporter (GLUT) protein is associated with poor prognosis in many cancers. In colorectal cancer, studies reporting the association between overexpression of GLUT and poor clinical outcomes were flawed by small sample sizes or subjective interpretation of immunohistochemical staining. Here, we analyzed mRNA expressions in all 14 SLC2A genes and evaluated the association with prognosis in colorectal cancer using data from the Cancer Ge

Molecular BiologyBiochemistry, Genetics and Molecular Biology
6
Article|74 citations·2018
Transoral Robotic Thyroidectomy for Papillary Thyroid Carcinoma: Perioperative Outcomes of 100 Consecutive Patients
Hong Kyu Kim, Young Jun Chai, Gianlorenzo Dionigi, Eren Berber, Ralph P. Tufano, Hoon Yub Kim, Hoon Yub Kim, Hoon Yub Kim
SJR Q1World Journal of Surgery

BACKGROUND: Endoscopic transoral thyroidectomy is a recently introduced technique of remote access thyroidectomy. We previously reported the feasibility of the robotic approach (TORT). Nevertheless, experience to date is limited, with scant data on outcomes in patients with papillary thyroid carcinoma (PTC). METHODS: This was a retrospective analysis of prospectively collected data. Patients with PTC, who underwent TORT at a single center between March 2016 and February 2017, were analyzed. RESU

SurgeryMedicine
7
Article|71 citations·2013
Papillary Thyroid Carcinoma Located in the Isthmus or Upper Third is Associated with Delphian Lymph Node Metastasis
Young Jun Chai, Su‐jin Kim, June Young Choi, Do Hoon Koo, Kyu Eun Lee, Yeo‐Kyu Youn
SJR Q1World Journal of Surgery

BACKGROUND: Delphian lymph node (DLN) metastasis is a recognized indicator of further lymph node involvement in papillary thyroid carcinoma (PTC). The aim of this study was to evaluate the clinicopathological significance of and risk factors for DLN metastasis. METHODS: The medical records of 1,436 patients who underwent primary thyroidectomy for classical PTC with a tumor size of 2 cm or less were reviewed. Of these, 370 patients from whom the DLN was harvested were enrolled. Metastasis in DLN

Endocrinology, Diabetes and MetabolismMedicine
8
Article|69 citations·2017
Comparative analysis of 2 robotic thyroidectomy procedures: Transoral versus bilateral axillo‐breast approach
Young Jun Chai, Hoon Yub Kim, Hoon Yub Kim, Hong Kyu Kim, Hong Kyu Kim, Sang-Ho Jun, Gianlorenzo Dionigi, Angkoon Anuwong, Jeremy D. Richmon, Ralph P. Tufano
SJR Q1Head & NeckOA

BACKGROUND: The surgical outcomes of a single surgeon's initial cases of transoral robotic thyroidectomy (TORT) were compared with the surgeon's initial cases of a bilateral axillo-breast approach (BABA) robotic thyroidectomy. METHODS: The medical reports were retrospectively reviewed. The BABA robotic thyroidectomies were performed between 2008 and 2009, and TORTs were performed between 2012 and 2016. RESULTS: Each group comprised 50 patients. Operative time for total thyroidectomy was shorter,

SurgeryMedicine
9
Article|66 citations·2018
Successful radiofrequency ablation strategies for benign thyroid nodules
Gee Mun Lee, Ji Young You, Hoon Yub Kim, Young Jun Chai, Hong Kyu Kim, Gianlorenzo Dionigi, Ralph P. Tufano, Gianlorenzo Dionigi, Ralph P. Tufano
SJR Q2Endocrine
Endocrinology, Diabetes and MetabolismMedicine
10
Article|62 citations·2021
Transoral Endoscopic Thyroidectomy Vestibular Approach (TOETVA): Surgical Outcomes and Learning Curve
Young Jun Chai, Sumin Chae, Moon Young Oh, Hyungju Kwon, Won Seo Park
SJR Q1Journal of Clinical MedicineOA

The transoral endoscopic thyroidectomy vestibular approach (TOETVA) has excellent cosmetic effects and its popularity is increasing worldwide. We present our experience with TOETVA and its short-term outcomes. This study included 110 consecutive patients who underwent TOETVA at a single institution between July 2016 and June 2020. We analyzed clinicopathologic data, short-term postoperative outcomes, and learning curve using cumulative summation (CUSUM) analysis. Of the 110 patients who underwen

SurgeryMedicine
11
Article|61 citations·2015
Clinicopathological characteristics and treatment outcomes of 38 cases of primary thyroid lymphoma: a multicenter study
Young Jun Chai, Jun Hyun Hong, Do Hoon Koo, Hyeong Won Yu, Joon‐Hyop Lee, Hyungju Kwon, Su‐jin Kim, June Young Choi, Kyu Eun Lee
SJR Q2Annals of Surgical Treatment and ResearchOA

Early stage PTL has an excellent prognosis when managed by single or combined treatment modalities. Clinicians should consider PTL in patients with underlying Hashimoto's thyroiditis presenting with an enlarging thyroid mass.

Endocrinology, Diabetes and MetabolismMedicine
12
Article|59 citations·2017
Lateral Transperitoneal Adrenalectomy Versus Posterior Retroperitoneoscopic Adrenalectomy for Benign Adrenal Gland Disease
Young Jun Chai, Hyeong Won Yu, Ra‐Yeong Song, Su‐jin Kim, June Young Choi, Kyu Eun Lee
SJR Q1Annals of Surgery

OBJECTIVE: The aim of this study was to compare the surgical outcomes of lateral transperitoneal adrenalectomy (LTA) and posterior retroperitoneoscopic adrenalectomy (PRA) for benign adrenal tumor. BACKGROUND: Although LTA is the standard treatment for benign adrenal gland tumor, PRA has recently gained popularity. Studies comparing the surgical outcomes of the 2 approaches have reported conflicting findings and thus it remains unclear which approach is superior. METHODS: This trial was conducte

SurgeryMedicine
13
Article|58 citations·2016
Surgical safety and oncological completeness of robotic thyroidectomy for thyroid carcinoma larger than 2 cm
Young Jun Chai, Hyunsuk Suh, Jung‐Woo Woo, Hyeong Won Yu, Ra‐Yeong Song, Hyungju Kwon, Kyu Eun Lee
SJR Q1Surgical Endoscopy
SurgeryMedicine
14
Article|51 citations·2016
A comparative study of postoperative pain for open thyroidectomy versus bilateral axillo-breast approach robotic thyroidectomy using a self-reporting application for iPad
Young Jun Chai, Junho Song, Jiyoung Kang, Jung‐Woo Woo, Ra-Yeong Song, Hyungju Kwon, Su‐jin Kim, June Young Choi, Kyu Eun Lee
SJR Q2Annals of Surgical Treatment and ResearchOA

Postoperative pain for BABA RT is equivalent to OT but offers greater cosmetic satisfaction for patients. A mobile device application such as SRA may facilitate proper assessment and management of pain in postoperative patients.

SurgeryMedicine
15
Article|50 citations·2019
Prognostic nomogram of hypoxia-related genes predicting overall survival of colorectal cancer–Analysis of TCGA database
Joon‐Hyop Lee, Sohee Jung, Won Seo Park, Eun Kyung Choe, Eun‐Young Kim, Rumi Shin, Seung Chul Heo, Jae‐Hyun Lee, Kwangsoo Kim, Young Jun Chai
SJR Q1Scientific ReportsOA

Hypoxia-related gene (HRG) expression is associated with survival outcomes of colorectal cancer (CRC). Our aim was developing a nomogram predicting CRC overall survival (OS) with HRGs and clinicopathological factors. The Cancer Genome Atlas (TCGA) database was used as discovery cohort and two Gene Expression Omnibus databases (GSE39582 and GSE41258) served as validation cohorts. A genetic risk score model prognosticating OS was developed using mRNA expression level of HRGs. Nomogram predicting O

Cancer ResearchBiochemistry, Genetics and Molecular Biology

Research Areas

SurgeryEndocrinology, Diabetes and MetabolismCancer ResearchComputer Vision and Pattern RecognitionNephrologyPhysiology

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