Kyoto University · 에너지
아키라 ヤマモト 교수의 연구실은 신경퇴행성 질환, 특히 알츠하이머병의 병태생리 기전을 규명하는 데 초점을 맞추고 있습니다. 주로 타우 단백질의 비정상적 중합을 유도하는 철(III)과 알루미늄 이온의 역할을 생화학적·생물물리학적 접근으로 규명하고 있으며, 이온의 산화 상태가 단백질 응집에 결정적인 영향을 미친다는 핵심 발견을 이끌어냈습니다. 또한, 광촉매 반응을 통한 환경 친화적 에너지 변환 기술과 생체분자 분석 기법 개발 등 다학제적 연구도 병행하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Abstract Iron as well as aluminum is reported to accumulate in neurons with neurofibrillary tangles (NFTs) of Alzheimer's disease (AD) brain. Previously we demonstrated that aluminum (III) shows phosphate‐dependent binding with hyperphosphorylated τ (PHFτ), the major constituent of NFTs, thereby inducing aggregation of PHFτ. Herein we report that iron (III) can also induce aggregation of soluble PHFτ. Importantly, for the aggregation of PHFτ to occur, iron in the oxidized state (III) is essentia
Iron as well as aluminum is reported to accumulate in neurons with neurofibrillary tangles (NFTs) of Alzheimer's disease (AD) brain. Previously we demonstrated that aluminum (III) shows phosphate-dependent binding with hyperphosphorylated tau (PHFtau), the major constituent of NFTs, thereby inducing aggregation of PHFtau. Herein we report that iron (III) can also induce aggregation of soluble PHFtau. Importantly, for the aggregation of PHFtau to occur, iron in the oxidized state (III) is essenti
CO<sub>2</sub> reforming with CH<sub>4</sub> proceeded at a low temperature (473 K) to form syngas over plasmonic Ni catalysts under visible light.
Effects of reaction temperature on the activity of photo-assisted selective catalytic reduction (photo-SCR) of NO with NH3 were investigated under very high GHSV conditions (100 000 h−1). The reaction temperature had a significant effect on the photo-SCR activity over a TiO2 photocatalyst. Maximum NO conversion was achieved at 433 K (NO conversion = 84%, N2 selectivity = 100%). The apparent activation energies in the low and high temperature range were evaluated to be 9.0 kJ mol−1 (353–433 K) an
Abstract Three spectrophotometric procedures for determination of chromatographically separated glycosphingolipids (cerebroside, sulfatide, ganglioside) are described and compared. Hydrolysis to release long chain base followed by reaction of the amino group with trinitrobenezene sulfonic acid (TNBS) and measurement at 340 mμ was shown to give values in good agreement with those obtained by reaction of the carbohydrate moiety with α‐naphthol or anthrone and measurement at 550 and 625 mμ respecti
The MutS family of DNA repair proteins recognizes base pair mismatches and insertion/deletion mismatches and targets them for repair in a strand-specific manner. Photocrosslinking and mutational studies previously identified a highly conserved Phe residue at the N-terminus of Thermus aquaticus MutS protein that is critical for mismatch recognition in vitro. Here, a mutant Escherichia coli MutS protein harboring a substitution of Ala for the corresponding Phe36 residue is assessed for proficiency
An alumina-supported metallic Rh catalyst (Rh/Al<sub>2</sub>O<sub>3</sub>) was found to be an effective catalyst in photo-assisted dry reforming of methane at around 473 K under visible and near-infrared light.
