Hokkaido University · 환경과학
아카키 아츠코 교수의 연구실은 주로 실내 환경 오염물질, 특히 인산염 에스터(Phthalates, PFRs)와 유해 화학물질의 인간 건강에 대한 영향을 중심으로 연구를 진행하고 있습니다. 특히 임신 기간 중의 환경 노출이 태아의 생식 호르몬 수치 및 아동기 알레르기 질환에 미치는 영향을 다루며, 다중 노출의 상호작용과 질병 유병률 간의 관계를 규명하고자 합니다. 실내 환경에서의 오염물질 농도 측정과 인체 노출 평가를 기반으로 한 에피디emi올로지적 연구가 핵심입니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Organophosphate esters are used as additives in flame retardants and plasticizers, and they are ubiquitous in the indoor environment. Phosphorus flame retardants (PFRs) are present in residential dust, but few epidemiological studies have assessed their impact on human health. We measured the levels of 11 PFRs in indoor floor dust and multi-surface dust in 182 single-family dwellings in Japan. We evaluated their correlations with asthma and allergies of the inhabitants. Tris(2-butoxyethyl) phosp
Prenatal di(2-ethylhexyl) phthalate (DEHP) exposure can produce reproductive toxicity in animal models. Only limited data exist from human studies on maternal DEHP exposure and its effects on infants. We aimed to examine the associations between DEHP exposure in utero and reproductive hormone levels in cord blood. Between 2002 and 2005, 514 pregnant women agreed to participate in the Hokkaido Study Sapporo Cohort. Maternal blood samples were taken from 23-35 weeks of gestation and the concentrat
Significant associations of mixed exposures to phthalates and PFRs and increased prevalence of rhinoconjunctivitis was found among elementary school-aged children in the WQS positive model. Mixed exposures were not associated with any of allergic symptoms in the WQS negative model or qg-computation approach. However, the combined effects of exposure to two PFRs suggested an additive and/or multiplicative interaction, potentially increasing the prevalence of rhinoconjunctivitis. A further study w
