The University of Tokyo · 의학
아ユ미 다쿠가치 교수의 연구실은 자궁경부암 유도에 핵심적인 역할을 하는 암 관련 섬유아세포(CAFs)와 염증, 세포 사멸 조절을 통한 종양 미세환경의 기전을 규명하는 데 초점을 맞추고 있습니다. 특히 오메가-3 오메가-6 지방산 대사, SIRT1 경로, TRAIL 및 손상 관련 단백질의 조절 메커니즘을 이용한 난소내막내피세포 및 자궁경부 전구암 세포에서의 암 발생 메커니즘을 다룹니다. 3D 생체모델 기반의 조직공학적 기법을 활용해 자궁경부 전이존의 생리적 특성과 암화 위험성을 분석하고 있으며, 다상태 마코프 모델을 활용한 CIN의 역방향 전환 동역학 분석도 진행 중입니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Cancer associated fibroblasts (CAFs) are responsible for tumor growth, angiogenesis, invasion, and metastasis. Matrix metalloproteinase (MMP)-9 secreted from cancer stroma populated by CAFs is a prerequisite for cancer angiogenesis and metastasis. Omega-3 polyunsaturated fatty acids (omega-3 PUFA) have been reported to have anti-tumor effects on diverse types of malignancies. Fat-1 mice, which can convert omega-6 to omega-3 PUFA independent of diet, are useful to investigate the functions of end
These opposing effects of SIRT1-related agents suggest that IL-8 release from the ESC is modulated through the SIRT1 pathway. Resveratrol may have the potential to ameliorate local inflammation in endometriomas.
This study indicates that RVT suppresses survivin expression and enhances TRAIL-induced apoptosis in ESCs.
The metaplastic epithelium of the transformation zone (TZ) including the squamocolumnar junction (SCJ) of the uterine cervix is a prime target of human papilloma virus (HPV) infection and subsequent cancer development. Due to the lack of adequate in vitro models for SCJ, however, investigations into its physiological roles and vulnerability to carcinogenesis have been limited. By using Matrigel-based three-dimensional culture techniques, we propagated organoids derived from the normal SCJ region
Cervical intraepithelial neoplasia (CIN) has a natural history of bidirectional transition between different states. Therefore, conventional statistical models assuming a unidirectional disease progression may oversimplify CIN fate. We applied a continuous-time multistate Markov model to predict this CIN fate by addressing the probability of transitions between multiple states according to the genotypes of high-risk human papillomavirus (HPV). This retrospective cohort comprised 6022 observation
