금보라 교수

Terlipressin-induced hyponatremia occurred frequently, especially in young patients with good liver function and higher Na level. Caution is required when administering terlipressin to patients with low body mass index.

See article in J. Gastroenterol. Hepatol. 2011; 26: 796–801.

The safety of polyethylene glycol plus ascorbic acid has not been fully investigated in patients with renal insufficiency. High-dose ascorbic acid could induce hyperoxaluria, thereby causing tubule-interstitial nephritis and renal failure. This study aims to evaluate the safety and efficacy of polyethylene glycol plus ascorbic acid in patients with chronic kidney disease.We retrospectively reviewed prospectively collected data on colonoscopy in patients with impaired renal function. Patients wer

Keum, Bora MD, PhD1; Jeen, Yoon Tae MD, PhD1; Park, Sung Chul MD1; Seo, Yeon Seok MD, PhD1; Kim, Yong Sik MD, PhD1; Chun, Hoon Jai MD, PhD1; Um, Soon Ho MD, PhD1; Kim, Chang Duck MD, PhD1; Ryu, Ho Sang MD, PhD1 Author Information

The efficacy of four different PPIs for H. pylori eradication is similar to each other. Smoking, site of ulcer, and the duration of treatment have significant effects on eradication rates.

Accumulating evidence has shown that sirtuin 7 (SIRT7), a mediator of various cellular activities, plays an important role in the pathogenesis of various immune-mediated inflammatory disorders. However, information remains limited regarding the role of SIRT7 in intestinal inflammation. We used a murine colitis model to investigate the role of SIRT7 in intestinal immunity and whether SIRT7 inhibitors could attenuate the intestinal inflammatory response. Mice were divided into three groups: contro

Diet restriction is one of the difficult parts of bowel preparation for colonoscopy, and many patients do not follow instructions properly. Few studies have evaluated the impact of dietary restriction in real clinical setting. The aim of this study was to study the effect of diet control on bowel preparation with detailed investigation of unacceptable food list in order to reveal what kind of foods are most problematic in clinical practice.Prospective observational study was carried out at a uni

In HBeAg-positive CHB patients infected with genotype C HBV, preC variant was associated with enhanced host immune response with lower HBV DNA levels, whereas CP variants were associated with severe liver damage and liver fibrosis progression.

목적: Helicobacter pylori (H. pylori) 감염의 치료로 proton pump inhibitor (PPI)를 기본으로 한 삼제 제균 요법은 소화성 궤양 치료와 합병증 예방에 효과가 있다. 여러 종류의 PPI의 약물역동학 차이에 따라 H. pylori 제균율에 미치는 영향에 대한 논의가 있었으나 국내에서 여러 PPI 간의 제균 효과 비교는 미미하다. 저자들은 최근 사용되는 PPI 4가지 제제를 포함한 삼제 요법의 제균 효과를 비교하고 제균율에 영향을 미치는 인자들을 알아보고자 하였다. 대상 및 방법: 2002년 5월부터 2004년 2월까지 고대안산병원 소화기내과에 내원하여 H. pylori 양성으로 판정한 환자들을 대상으로 하여 omeprazole, rabeprazole, esomeprazole, lansoprazole 중 하나를 선택하여 PPI 포함 삼제 요법으로 1주 혹은 2주 제균 치료를 시행하였다. 약물 복용 여부, 부작용, 흡연 여부를 조사하였으며, 치료

The regulation of apoptosis is the primary goal of ablation therapy. Irreversible electroporation (IRE) is a promising non-thermal tissue ablation-based therapy that induces apoptosis by manipulating electrical conditions. This study aimed to investigate IRE-induced gastric tissue apoptosis in response to changes in the electric field intensity, followed by the repair process. Among the 52 rats used in this study, 24 were used to explore apoptosis, and 28 were used to study regeneration. The apo

Compared with 2 L-PEG/Asc, 1 L-PEG/Asc achieved successful overall bowel cleansing efficacy with high-quality cleansing in the proximal colon and proved its noninferiority. Therefore, 1 L-PEG/Asc is an acceptable alternative bowel cleansing solution.