Chang Seok Ki
서울대학교 Materials Science · 재료과학
장석기 교수의 연구실은 생체재료 및 조직공학 분야에서 활발한 연구를 수행하고 있으며, 특히 재생의학적 응용을 위한 나노섬유 기반 3차원 생체모델 개발에 초점을 맞추고 있습니다. 실험적 세포 배양 환경의 한계를 극복하고자, 실리크로핀 기반 나노섬유 스캐폴드, 하이드로젤, 탈세포화 세포외기질 기반 3차원 배양 시스템을 개발하여 암세포의 생존 및 약물 반응성을 보다 현실적으로 재현하고자 합니다. 특히, 종양 미세환경을 모사하는 생물학적 유사 배양 시스템을 통해 암 치료제의 효과를 정밀하게 평가할 수 있는 플랫폼을 구축하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Abstract Practical application to three‐dimensional (3‐D) tissue culture has been limited by the structural restriction of two‐dimensional (2‐D) nature of electrospun nanofiber mat. In this study, for constructing 3‐D nanofibrous structure as real 3‐D tissue engineering scaffold, we developed new fabrication process with silk fibroin (SF) by electrospinning and evaluated the features of this SF nanofiber scaffold (SFNS) through morphological and cell‐culture analyses. Foam type of the SFNS exhib
Abstract Regenerated silk fibroin (SF) filaments could be prepared by wet spinning in common solvent/coagulation system. SF was directly dissolved in mixture solvent of phosphoric acid and formic acid (20/80–30/70 ratio) and coagulated in methanol bath. The concentration and stability of SF dope solution have been studied by varying the mixture ratios of these solvents in accordance with elucidating the role of formic acid in the mixture solvent system. Morphological structure as well as crystal
Hydrogel formation by more than two cross-linking mechanisms is preferred for the sophisticated manipulation of hydrogel properties. Both chemical and physical crosslinks are often utilized for fabricating stimuli-responsive hydrogels or for compensating the drawbacks of the single crosslinking method. In this study, silk fibroin (SF) microgel embedded poly(ethylene glycol) (PEG) hydrogels were fabricated by dual mode cross-linking based on thiol-ene photo-click chemistry and β-sheet formation o
Therapeutics to inhibit signaling of epidermal growth factor receptor (EGFR) has been suggested as a potential treatment for pancreatic cancers, and two-dimensional (2D) cell culture techniques are commonly used to identify and/or verify the therapeutic efficacy of EGFR inhibitors. However, drug targets identified from conventional cell culture techniques may not exhibit desired functions when these drugs are tested in animal studies, in large part due to the complicated tumor microenvironments.
Silk is a textile material, as well as one of the oldest biomaterials. However, the recent progress of biomedical science and technology has led to the replacement of silk by various biomaterials based on synthetic polymers. Despite the wide variety of biomaterials available, these materials suffer certain limitations that prevent them from meeting the various demands of the medical field. Therefore, silk continues to attract considerable interest as a promising biomaterial. This paper explains
