Changwon Kee
성균관대학교 의과대학 · 의학
창원기 교수의 연구실은 원추성 망막병변과 녹내망막병변의 병태생리학적 기전을 규명하고, 특히 정상내압성 녹내망의 혈관성 병변과 시신경섬유층 손상의 상관관계를 중심으로 연구를 진행하고 있습니다. 특히, 시신경섬유층의 퇴행과 연관된 망막미소혈관망의 변화, 약물 치료 반응 및 수술적 접근의 최적화에 초점을 맞추고 있으며, 시신경판 크기의 영향을 고려한 진단 기준 개선도 함께 연구하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
The partial ligation of a tube in Ahmed glaucoma valve implantation suggested a lower rate of hypotony and surgical complications. There was no significant difference in final success rate between the partial ligation and nonligation groups.
PPG eyes and normal eyes were found to have the similar densities of peripapillary microvasculature at the area with nerve fiber layer defect, whereas in PG eye, there was a significant decrease in vessel density at the area of RNFL thinning. This provides evidence that microvascular compromise in the retina might be a secondary change to nerve fiber layer degeneration in the pathogenesis of NTG.
Because patients with considerable JOAG had no definite symptoms, periodic eye examinations are needed. To prevent the VF's progression, JOAG patients may require more careful management of intraocular pressure.
cGMP may be involved in the regulation of aqueous humor formation and outflow facility and their responses to pharmacologic agents.
Optic disc size, but not age, should be considered in the interpretation of optic disc variables.
Stromelysin, a functional gene, can be transferred in vivo into rat eyes and in vitro into cultured human trabecular cells using a replication-deficient adenovirus vector. This shows the possibility of gene therapy in glaucoma.
To identify TIGR gene mutation in two Korean pedigrees of primary open-angle glaucoma (POAG), and in 25 steroid-induced glaucoma patients, TIGR gene assay was performed. Genomic DNA was extracted from peripheral blood and the TIGR gene was amplified by polymerase chain reaction (PCR). The PCR amplification products were evaluated by single-stranded conformation polymorphism and direct DNA sequencing. In POAG families, not only those patients clinically diagnosed as glaucoma, but also most of the
Episcleral application of mitomycin C can produce at least a modest short-term reduction of aqueous humor flow in primates. Reduced aqueous flow might contribute to early postoperative hypotony following trabeculectomy with mitomycin C.
