안철희 교수

Double spotlight: A dual imaging probe with gold nanoparticles (AuNPs) for computed tomography (CT) and optical imaging exhibits have been developed (see picture). The excellent stability, tumor targeting ability, enhanced X-ray absorption, and matrix metalloproteinase (MMP) activatable fluorescence recovery was achieved by surface modification of AuNPs with glycol chitosan and fluorescent MMP peptide probes. Detailed facts of importance to specialist readers are published as ”Supporting Informa

Prodrugs are bioreversible medications that should undergo an enzymatic or chemical transformation in the tumor microenvironment to release active drugs, which improve cancer selectivity to reduce toxicities of anticancer drugs. However, such approaches have been challenged by poor therapeutic efficacy attributed to a short half-life and low tumor targeting. Herein, we propose cathepsin B-overexpressed tumor cell activatable albumin-binding doxorubicin prodrug, Al-ProD, that consists of a albumi

Abstract Methoxy PEG amine with molecular weight of 5k and ε ‐caprolactone with molecular weight of 1 960 were conjugated to a peptide comprising three cysteine residues. The shift of peak molecular weight and narrow molecular weight distribution in GPC trace without any noticeable shoulder as well as 1 H NMR analysis confirmed the successful synthesis of the copolymer. A modified O/W dialysis system was employed to prepare self‐aggregates having the size around 210 nm. During the dialysis, stab

Zweifach im Blickpunkt: Eine duale Goldnanopartikel(AuNP)-Sonde für die Computertomographie (CT) und optische Bildgebung wurde entwickelt. Ihre exzellenten Eigenschaften – Stabilität, Tumorerkennung, Röntgenabsorption und Matrixmetalloproteinase(MMP)-aktivierbare Fluoreszenzwiederherstellung – wurden durch Oberflächenmodifikation der AuNPs mit Glycolchitosan und MMP-Fluoreszenzsonden erreicht. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such docu

Abstract Summary: Dendrons and dendrimers with cationic amino groups at their periphery were successfully synthesized up to the third and second generation, respectively. The results obtained by 1 H NMR spectroscopy and gel permeation chromatography analysis supported the formation of the targeted dendrons and dendrimers. The dendrons were grown via ester linkages, which endowed them with biodegradability in D 2 O at 37 °C. The degradation rate depends upon the steric hindrance and reactivity ca

Abstract Multi‐arm poly(THF)‐ b ‐polyglycerol linear‐hyperbranched copolymers consisting of a linear hydrophobic poly(THF) block and a hyperbranched hydrophilic polyglycerol block were synthesized by ring opening polymerization of tetrahydrofuran with silver trifluoromethane sulfonate as a catalyst and the consecutive polymerization of glycidol. Initiators with different geometries that propagated into different numbers of arms (e.g., 1, 2 or 4) were used to investigate the dependence of the mic

The polymerization of 2-butene and its copolymerization with ethylene have been investigated using four kinds of dichlorobis(β-diketonato)titanium complexes, [ArN(CH2)3NAr]TiCl2 (Ar = 2,6-iPr2C6H3) and typical metallocene catalysts. The obtained copolymers display lower melting points than those produced of homopolyethylene under the same polymerization conditions. 13C NMR analysis indicates that 9.3 mol-% of 2-butene units were incorporated into the polymer chains with Ti(BFA)2Cl2-MAO as the ca

Abstract Oppositely charged F127 copolymers with a substitution ratio >95% were synthesized by end‐group modification. Single succinic anhydride end‐capped F127 (F127‐SA) or triple (F127‐Tris‐SA) carboxylic acid groups were introduced to the distal ends via esterification. F127 was also end‐capped with two types of amines, triethylenetetramine (F127‐TETA) and ethylene diamine (F127‐EDA). Oppositely charged copolymers were solution‐blended to produce co‐micellized nanostructures at the optimiz

Abstract Chemical recycling to monomer (CRM) provides an ideal solution for reducing plastic waste and achieving a circular polymer economy. Cyclopentene (CP) and its derivatives are representative molecules that exemplify an efficient CRM process under mild conditions. However, most CP‐based polymers possess limited thermal and mechanical properties, constraining their potential applications. Herein, new CP‐based polymers with superior thermo‐mechanical properties and autonomous functions are p

Copper-based nanomaterials have been employed as therapeutic agents for cancer therapy and diagnosis. Nevertheless, persistent challenges, such as cellular toxicity, non-uniform sizes, and low photothermal efficiency, often constrain their applications. In this study, we present Cu²⁺-loaded silica nanoparticles fabricated through the chelation of Cu²⁺ ions by silanol groups. The integration of Cu²⁺ ions into uniformly sized silica nanoparticles imparts a photothe

A surface modification technology with dendritic-structured poly(ethylene glycol) to protect islets from the host immune system was proposed for pancreatic islet transplantation.

Co-delivery of microbubbles (MBs) with anticancer drugs is a promising theranostic approach that can enhance both the ultrasound contrast and local extravasation of drugs with the sonoporation effect. The simultaneous administration of MBs and hydrophobic drugs, however, is still challenging due to the limitations in drug loading or undesirable stabilization of MBs. In this research, MB-self-aggregate complexes (MB-SAs) were newly fabricated for the encapsulation of hydrophobic drugs, and their

Endovascular embolization is a promising therapeutic approach broadening its application area due to its minimal invasiveness and short operation time, wherein lesional blood vessels are occluded with liquid embolic agents under X-ray imaging guidance. Histoacryl and its composition with Lipiodol are one of the most widely used liquid embolic agents, however, Histoacryl has critical limitations, such as lack of innate X-ray visibility and strong adhesion to microcatheter. In this study, three di