Nagoya University · 생화학·유전·분자생물학
다이스케 마리 교수의 연구실은 신경발달 및 신경정신질환의 분자 기전을 규명하는 데 초점을 맞추고 있습니다. 특히 세포 분열과 뉴런 이동을 조절하는 마이크로튜불루스 시스템, 예를 들어 NDEL1과 LIS1의 상호작용, 그리고 Aurora-A 및 CDK1에 의한 단백질 인산화와 분해 메커니즘을 중심으로 연구를 진행하고 있습니다. 또한 정신질환, 특히 조현병과 관련된 유전적 요인으로서 ARHGAP10 유전자 내 복수형질변이유(CNV)의 기능적 영향을 규명하고 있으며, RNA 결합 단백질 CUG-BP1이 RNA 결합 특이성과 기능적 역할을 어떻게 조절하는지에 대해서도 분석하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
NDEL1 is a binding partner of LIS1 that participates in the regulation of cytoplasmic dynein function and microtubule organization during mitotic cell division and neuronal migration. NDEL1 preferentially localizes to the centrosome and is a likely target for cell cycle-activated kinases, including CDK1. In particular, NDEL1 phosphorylation by CDK1 facilitates katanin p60 recruitment to the centrosome and triggers microtubule remodeling. Here, we show that Aurora-A phosphorylates NDEL1 at Ser251
Schizophrenia (SCZ) is known to be a heritable disorder; however, its multifactorial nature has significantly hampered attempts to establish its pathogenesis. Therefore, in this study, we performed genome-wide copy-number variation (CNV) analysis of 2940 patients with SCZ and 2402 control subjects and identified a statistically significant association between SCZ and exonic CNVs in the ARHGAP10 gene. ARHGAP10 encodes a member of the RhoGAP superfamily of proteins that is involved in small GTPase
CUG-binding protein 1 (CUG-BP1) is a member of the CUG-BP1 and ETR-3-like factors (CELF) family of RNA-binding proteins, and is involved in myotonic dystrophy type 1 (DM1). Several mRNA targets of CUG-BP1 have been identified, including the insulin receptor, muscle chloride channel, and cardiac troponin T. On the other hand, CUG-BP1 has only a weak affinity for CUG repeats. We conducted quantitative-binding assays to assess CUG-BP1 affinities for several repeat RNAs by surface plasmon resonance
