東北大学 · Medicine
다이스케 쇼노 교수의 연구실은 수자원 재이용과 환경 안전을 핵심 목표로 삼고 있으며, 특히 바이러스의 환경적 존재와 기능을 정량적으로 평가하는 데 초점을 맞추고 있습니다. 기존 임상 검사의 한계를 보완하는 와이파이드 기반 역학학(WBE) 기반의 전염병 조기경보 시스템 개발과 함께, 비배양 가능한 장내 바이러스(예: 노로바이러스, 사포바이러스)의 감염성 평가 및 산화 손상 분석 기법을 개발하고 있습니다. 또한, 수처리 과정에서 바이러스를 효과적으로 제거하기 위한 CT 값 기반의 소독 성능 평가 및 막 생물반응기(MBR)를 활용한 수질 재활용 기술의 안전성 확보에 관한 연구를 진행하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
The highly enantioselective catalytic hydroxylation of 3-substituted oxindoles was achieved by using a phase-transfer catalyst with molecular oxygen as an oxidant. The product then was converted to an optically active compound 8, which was a synthetic precursor of alkaloid CPC-1.
An effective early warning tool is of great administrative and social significance to the containment and control of an epidemic. Facing the unprecedented global public health crisis caused by COVID-19, wastewater-based epidemiology (WBE) has been given high expectations as a promising surveillance complement to clinical testing which had been plagued by limited capacity and turnaround time. In particular, recent studies have highlighted the role WBE may play in being a part of the early warning
The infectivity evaluation of noncultivatable viruses, such as human norovirus, is crucial to address needs for ensuring the safety in usage of water and marine products. In this work, we tested a new approach to evaluate viral particle integrity, in which oxidatively produced carbonyl groups on viral capsid protein were quantitatively detected. As a result, the decrease in the infectivity of human astrovirus, a representative enteric virus, positively correlated with the amount of oxidative dam
A credit value of virus inactivation has been assigned to the disinfection step in international and domestic guidelines for wastewater reclamation and reuse. To fulfill the credit value for water disinfection, water engineers need to apply an appropriate disinfection strength, expressed as a CT value (mg × min/L), which is a product of disinfectant concentration and contact time, against enteric viruses in wastewater. In the present study, we extracted published experimental data on enteric vir
Human sapoviruses (SaVs) were quantified and characterized in an 18-month survey conducted along the Llobregat river catchment area in Spain. Sample types included freshwater, untreated and treated wastewater, and drinking water. All genogroups were recovered, and a seasonal distribution was observed. This is the first report of SaV quantification and genotyping in the environment outside Japan.
The increasing pressure on the global water supply calls for more advanced solutions with higher efficiency and better sustainability, leading to the promptly developing water reclamation and reuse schemes including treatment technologies and risk management strategies where microbial safety is becoming a crucial aspect in the interest of public health. Backed up by the development of membrane technology, membrane bioreactors (MBR) have received substantial attention for their superiority over c
Estimating and predicting the epidemic size from wastewater surveillance results remains challenging for the practical implementation of wastewater-based epidemiology (WBE). In this study, by employing a highly sensitive detection method, we documented the time series of SARS-CoV-2 RNA occurrence in the wastewater influent from an urban community with a 360,000 population in Japan, from August 2020 to February 2021. The detection frequency of the viral RNA increased during the outbreak events of
