Dong Jun Park
연세대학교 의과대학 · 의학
Dong Jun Park 교수의 연구실은 생물의학 및 나노소재 분야에서 다학제적 연구를 수행하고 있습니다. 식물 질병 및 해충의 빠른 진단을 위한 딥러닝 기반 이미지 분석 기술, 간세포암세포의 면역 회피 메커니즘, 나노입자가 면역세포 및 간세포에서 세포외소포를 유도하는 메커니즘 등 세포 및 분자 수준의 병리학적 메커니즘 규명에 초점을 맞추고 있습니다. 또한, ZnO 나노소재의 성장 메커니즘과 특성 제어를 통해 나노전자 및 바이오센서 응용 가능성을 탐색하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Plant Diseases and Pests are a major challenge in the agriculture sector. An accurate and a faster detection of diseases and pests in plants could help to develop an early treatment technique while substantially reducing economic losses. Recent developments in Deep Neural Networks have allowed researchers to drastically improve the accuracy of object detection and recognition systems. In this paper, we present a deep-learning-based approach to detect diseases and pests in tomato plants using ima
Our data demonstrated that EpCAM<sup>high</sup> liver CSCs resist NK cell-mediated cytotoxicity by upregulation of CEACAM1 expression.
Finger veins have been proved to be an effective biometric for personal identification in the recent years. However, finger vein images are easily affected by influences such as image translation, orientation, scale, scattering, finger structure, complicated background, uneven illumination, and collection posture. All these factors may contribute to inaccurate region of interest (ROI) definition, and so degrade the performance of finger vein identification system. To improve this problem, in thi
It was concluded that the nanoparticles we developed were transported to the lysosome by clathrin-mediated endocytosis. additionally, entered nanoparticles stimulated that autophagy related factors to release exosome from the MSC. MSC-derived exosomes using nanoparticles may increase exosome yield and enable the discovery of nanoparticle-induced genetic factors.
AKI is often associated with acute renal infarction. Although most AKI recovers spontaneously, renal impairment following acute renal infarction can persist. Thus, early diagnosis and intervention are needed to preserve renal function.
The use of colistin in the treatment of multidrug-resistant Gram-negative bacterial infections is restricted due to nephrotoxicity. We investigated the effects of aged black garlic extract (ABGE) on colistin-induced kidney injury in rats. Rats were assigned to four groups. Normal saline was intraperitoneally and intragastrically injected for control group. ABGE was intragastrically injected for garlic group. Ten mg/kg of colistin was intraperitoneally injected for 6 consecutive days for colistin
Contrast-induced acute kidney injury (CI-AKI) is the third most common cause of hospital-acquired renal failure, with an incidence of 11%. However, the disease mechanism remains unclear, and no effective treatment is available. Paricalcitol has been reported to be effective in animal models of kidney injury. We hypothesized that paricalcitol could play a renoprotective role against CI-AKI. Rats were divided into control, paricalcitol, contrast, and paricalcitol-plus-contrast groups. We used a pr
Chronic metabolic diseases such as diabetes are characterized by delayed wound healing and a dysregulation of the inflammatory phase of wound repair. Our study focuses on changes in the payload of extracellular vesicles (EVs) communicating between immune cells and stromal cells in the wound bed, which regulate the rate of wound closure. Adoptive transfer of EVs from genetically defined mouse models are used here to demonstrate a functional and molecular basis for differences in the pro-reparativ
The growth direction and morphology of one-dimensional ZnO nanostructures grown by metal–organic chemical vapour deposition (MOCVD) were modulated by changing the growth temperature of previously deposited ZnO buffer layers that were used as a template. The ZnO nanorods grown on the low-temperature deposited buffer layer were regularly inclined with respect to the substrate surface and show in-plane alignment with azimuthally six-fold symmetry. In contrast, deposition of the buffer layer at high
Zr alloy specimens were coated with Cr–Al alloy to enhance their resistance to oxidation. The coated samples were oxidized at 1200 °C in a steam environment for 300 s and showed extremely low oxidation when compared to uncoated Zr alloy specimens. The microstructure and elemental distribution of the oxides formed on the surface of Cr–Al alloys have been investigated by transmission electron microscopy (TEM) and X-ray photoelectron spectroscopy (XPS). A very thin protective layer of Cr2O3 formed
We report the evolution of ZnO nanorods by metalorganic chemical vapor deposition on sapphire substrates and an investigation of their microstructure. Well-aligned ZnO nanorods with a high aspect ratio were grown on an interfacial layer with several types of defects at a lower reactor pressure. Planar defects such as stacking mismatch boundaries and inversion domain boundaries were formed in the interfacial layer during the coalescence of the islands, and finally constituted the side facets of t