Dong-Kwon Lim
고려대학교 융합에너지공학과 · 공학
Dong-Kwon Lim 교수의 연구실은 나노소재를 활용한 의료 진단 및 치료 기술 개발에 초점을 맞추고 있습니다. 특히 금 나노입자 기반 광열 효과와 표면-enhanced 라만 산란(SERS) 기반 생물분석 기술을 통해 빠르고 정밀한 세균 진단 및 세포 내 분자 정보 분석을 연구하고 있습니다. 최근에는 PCR 대체 기술로 유망한 광열 반응 기반 진단 기법과 단일세포 내 생체분자의 SERS 분석 기술 개발에 주력하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Gold nanoparticles (AuNPs) have received great attention for various medical applications due to their unique physicochemical properties. AuNPs with tunable optical properties in the visible and near-infrared regions have been utilized in a variety of applications such as in vitro diagnostics, in vivo imaging, and therapeutics. Among the applications, this review will pay more attention to recent developments in diagnostic and therapeutic applications based on the photothermal (PT) effect of AuN
Sepsis is a critical disease caused by the abrupt increase of bacteria in human blood, which subsequently causes a cytokine storm. Early identification of bacteria is critical to treating a patient with proper antibiotics to avoid sepsis. However, conventional culture-based identification takes a long time. Polymerase chain reaction (PCR) is not so successful because of the complexity and similarity in the genome sequence of some bacterial species, making it difficult to design primers and thus
SERS have been attracted as a bioanalytical tool by utilizing plasmonic nanomaterials to enhance the intensity of Raman scattering. Two different analytes such as nucleic acid target or natural biomolecules inside single cell have been investigated in our research group. For nucleic acid target, it is inevitable for the use of surrogate to determine the presence of specific nucleic acid target. Our recent study showed that SERS is superior to assay performance of fluorescence-based assay (Sensor
