Dongryeol Ryu
성균관대학교 의과대학 · 의학
Dongryeol Ryu 교수의 연구실은 근육 질환, 노화, 대사 질환 및 암 치료 저항성과 관련된 세포 및 대사 기전을 중심으로 연구를 진행하고 있습니다. 특히 NAD⁺ 대사, 미토콘드리아 기능 이상, 미토킨인 GDF15의 역할, 근육 재생을 위한 조직공학적 전략, 그리고 암세포의 대사 재편이 약물 저항성에 미치는 영향에 초점을 맞추고 있습니다. 이는 신약 타겟 발굴과 질병 치료 전략 개발에 기여할 잠재력을 지닌 기초의학 연구입니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Neuromuscular diseases are often caused by inherited mutations that lead to progressive skeletal muscle weakness and degeneration. In diverse populations of normal healthy mice, we observed correlations between the abundance of mRNA transcripts related to mitochondrial biogenesis, the dystrophin-sarcoglycan complex, and nicotinamide adenine dinucleotide (NAD<sup>+</sup>) synthesis, consistent with a potential role for the essential cofactor NAD<sup>+</sup> in protecting muscle from metabolic and
Mitochondrial dysfunction is associated with aging-mediated inflammatory responses, leading to metabolic deterioration, development of insulin resistance, and type 2 diabetes. Growth differentiation factor 15 (GDF15) is an important mitokine generated in response to mitochondrial stress and dysfunction; however, the implications of GDF15 to the aging process are poorly understood in mammals. In this study, we identified a link between mitochondrial stress-induced GDF15 production and protection
Volumetric muscle loss (VML) is associated with a severe loss of muscle tissue that overwhelms the regenerative potential of skeletal muscles. Tissue engineering has shown promise for the treatment of VML injuries, as evidenced by various preclinical trials. The present study describes the fabrication of a cell-laden GelMa muscle construct using an <i>in situ</i> crosslinking (ISC) strategy to improve muscle functionality. To obtain optimal biophysical properties of the muscle construct, two UV
These results demonstrate that ER stress-induced LIPIN2 would contribute to the perturbation of hepatic insulin signaling via a DAG-protein kinase C ε-dependent manner in DIO mice.
Resistance to anticancer therapeutics occurs in virtually every type of cancer and becomes a major difficulty in cancer treatment. Although 5-fluorouracil (5FU) is the first-line choice of anticancer therapy for gastric cancer, its effectiveness is limited owing to drug resistance. Recently, altered cancer metabolism, including the Warburg effect, a preference for glycolysis rather than oxidative phosphorylation for energy production, has been accepted as a pivotal mechanism regulating resistanc
