유동원 교수

Early detection and treatment of disease is the most important component of a favorable prognosis. Biomedical researchers have thus invested tremendous effort in improving imaging techniques and treatment methods. Over the past decade, concepts and tools derived from nanotechnology have been applied to overcome the problems of conventional techniques for advanced diagnosis and therapy. In particular, advances in nanoparticle technology have created new paradigms for theranostics, which is define

A solution-phase synthetic protocol to form two-dimensional (2D) single-layer transition-metal chalcogenides (TMCs) has long been sought; however, such efforts have been plagued with the spontaneous formation of multilayer sheets. In this study, we discovered a solution-phase synthetic protocol, called "diluted chalcogen continuous influx (DCCI)", where controlling the chalcogen source influx (e.g., H2S) during its reaction with the transition-metal halide precursor is the critical parameter for

Energy efficiency is becoming a key issue in the development of thermal management devices. To this end, thermal performance of plate fin and pin fin heat sinks incorporating a solid-liquid phase change material (PCM) has been evaluated, under periodic power inputs simulating actual heating conditions. Experiments were performed using Wood's metal (50Bi/27Pb/13Sn/10Cd, melting point: 70.0/spl deg/C) under forced convection in a wind tunnel, and also with an integrated fan. A periodic on/off powe

Highly efficient apoptotic hyperthermia is achieved using a double-effector nanoparticle that can generate reactive oxygen species (ROS) and heat. ROS render cancer cells more susceptible to subsequent heat treatment, which remarkably increases the degree of apoptotic cell death. Xenograft tumors (100 mm(3)) in mice are completely eliminated within 8 days after a single mild magnetic hyperthermia treatment at 43 °C for 30 min.

Visible-light-driven organic transformations are of great interest in synthesizing valuable fine chemicals under mild conditions. The merger of heterogeneous photocatalysts and transition metal catalysts has recently drawn much attention due to its versatility for organic transformations. However, these semi-heterogenous systems suffered several drawbacks, such as transition metal agglomeration on the heterogeneous surface, hindering further applications. Here, we introduce heterogeneous single

[reaction: see text] Efficient synthesis of enantiomerically pure (-)-statine was achieved with the stereoselective intramolecular conjugate addition of the hydroxyl group tethered to the amino group of a configurationally stable N-Boc-L-leucinal derivative.

Gegen jeden Widerstand: Wärmebehandelte Krebszellen haben einen schützenden Resistenz- und Überlebensmechanismus. Resistenzfreie Zelltod-induzierende magnetische Nanopartikel (RAINs) fördern den hyperthermalen Zelltod, indem sie die Wärmeerzeugung und das Freisetzen von Geldanamycin (GM) zur Hemmung des Hitzschockproteins (Hsp) in einem magnetischen Wechselfeld (AMF) einleiten (siehe Bild) und somit das Überleben der Zelle hindern. As a service to our authors and readers, this journal provides s

An efficient synthesis of a configurationally stable l-serinal derivative 8 was achieved using an N-hydroxymethyl group in about 50% overall yield in four steps from l-serine. Not more than 1% racemization was observed during the preparation of 8. Its enantiomeric integrity was maintained for at least 15 days at room temperature, and it was stable on silica gel. The orthogonal protective groups of 8 would make it a useful chiral synthon.

The development of a full-vertical GaN p-i-n rectifier on a 6H n-type SiC substrate by employing a conducting AlxGa1−xN:Si (x=∼0.1) buffer layer scheme is reported. In this vertical configuration, the n contact is made on the backside of the SiC substrate using a Ni∕Au metallization scheme. Epitaxial layers are grown by low-pressure metal organic chemical vapor deposition. The AlxGa1−xN:Si nucleation layer is proven to provide excellent electrical properties while also acting as a good buffer la

<para xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink"> Al<emphasis><formula formulatype="inline"><tex>$_{x}$</tex></formula></emphasis>Ga<emphasis><formula formulatype="inline"><tex>$_{1 - x}$</tex></formula></emphasis>N <emphasis><formula formulatype="inline"><tex>$(x = 0.05)$</tex></formula></emphasis> ultraviolet (UV) avalanche photodiodes grown on a GaN substrate are reported. The epitaxial structure was grown by metal–organic chemical vapor depositi

Single-atom photocatalysis has shown potential in various single-step organic transformations, but its use in multistep organic transformations in one reaction systems has rarely been achieved. Herein, we demonstrate atomic site orthogonality in the M₁/C₃N₄ system (where M = Pd or Ni), enabling a cascade photoredox reaction involving oxidative and reductive reactions in a single system. The system utilizes visible-light-generated holes and electrons from C<sub>3<

Hoch effiziente apoptotische Hyperthermie ergeben magnetische Nanopartikel, die in einer Doppelfunktion sowohl reaktive Sauerstoffspezies (ROS) als auch Wärme erzeugen. Durch die ROS werden Krebszellen verwundbarer für die anschließende Wärmebehandlung: 100 mm3 große implantierte Tumore in Mäusen werden nach 30 min Hyperthermiebehandlung bei 43 °C binnen 8 Tagen vollständig eliminiert. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents ar

Abstract Chiral hybrid organic–inorganic perovskites (HOIPs) have garnered considerable research interest in the field of optoelectronics, owing to their ability to integrate outstanding optoelectronic characteristics with distinct chiral or spin‐related properties. Although recent years have witnessed the rapid development of chiral perovskites, methods for producing perovskites with high absorption dissymmetry factors ( g CD ) enabling polarization‐resolved chiroptical applications are still l

Surface plasmon resonance (SPR) phenomena have been widely studied to detect biomolecules because of their high sensitivity and ability to determine biomolecular interactions with kinetic information. However, highly selective detection in specific concentration ranges relevant to target biomolecules is still a challenging task. Recently, we developed bioresponsive nanoscale hydrogels to selectively intensify SPR signals through multivalent protein binding (MPB) events with target biomolecules,