성균관대학교 · Biochemistry, Genetics and Molecular Biology
이 교수의 연구실은 주로 생체 적합성 고분자 기반의 스마트 약물 및 유전자 전달 시스템을 개발하는 데 초점을 맞추고 있습니다. 온도나 pH 변화에 반응하는 생분해성 하이드로젤, 마이셀, 나노입자 등 다양한 자가조립 구조를 활용해 약물의 정밀한 방출과 병변 부위 집중 전달을 실현하고자 합니다. 특히, 다중 약물 또는 약물과 유전자를 동시에 전달하는 복합형 나노시스템의 설계 및 응용에 대한 연구가 두드러집니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Injectable biodegradable copolymer hydrogels, which exhibit a sol-gel phase transition in response to external stimuli, such as temperature changes or both pH and temperature (pH/temperature) alterations, have found a number of uses in biomedical and pharmaceutical applications, such as drug delivery, cell growth, and tissue engineering. These hydrogels can be used in simple pharmaceutical formulations that can be prepared by mixing the hydrogel with drugs, proteins, or cells. Such formulations
The BAB-type triblock copolymers composed of a central poly(ethylene oxide) (PEO, M̄nPEO = 1 000) block and two poly[(D,L-lactic acid)-co-(glycolic acid)] end blocks with molecular weights between 900 and 1 600 exhibited an interesting phase transition behavior. The copolymer aqueous solution can form micelles with PLGA loops in the core and a PEO shell and groups of micelles because of bridging between micelles caused by the PLGA blocks with raising temperature. A possible micellar gelation mec
Polymeric nanoparticles are promising candidates as drug and gene carriers. Among polymeric nanoparticles, those that are responsive to internal or external stimuli are of greater interest because they allow more efficient delivery of therapeutics to pathological regions. Stimulus-sensitive polymeric nanoparticles have been fabricated based on numerous nanostructures, including micelles, vesicles, crosslinked nanoparticles, and hybrid nanoparticles. The changes in chemical or physical properties
Drug and gene delivery systems based on nanoparticles, microparticles and hydrogels have been widely studied for cancer treatment in the past decade. To achieve an efficient and safe delivery, selection of drug and gene delivery carrier is critical. Biocompatible polymeric nanoparticles are considerably promising carrier candidates in delivery of drugs and genes because of their unique chemical and physical properties. However, delivery of a drug or gene sometimes cannot achieve a satisfactory t
Poly(ethylene oxide)-b-poly(L-lactic acid) (PEO-PLLA) diblock copolymers were synthesized via a ring opening polymerization from poly(ethylene oxide) and l-lactide. Stannous octoate was used as a catalyst in a solution polymerization with toluene as the solvent. Their physicochemical properties were investigated by using infrared spectroscopy, 1H-NMR spectroscopy, gel permeation chromatography, and differential scanning calorimetry, as well as the observational data of gel-sol transitions in aqu
