Eiichi Nakamura 교수

Fullerenes are entirely insoluble in water, but suitable functionalization makes the molecules soluble. Studies on water-soluble fullerene derivatives led to the discovery of the interaction of organofullerenes with DNA, proteins, and living cells, which was first reported in the summer of 1993. Subsequent studies have revealed interesting biological activity aspects of organofullerenes owing to their photochemistry, radical quenching, and hydrophobicity to form one- to three-dimensional supramo

The use of iron as a catalyst for organic synthesis has been increasingly attracting the interest of chemists from economical and ecological points of view. While Fe(III) and Fe(II) catalysts have long been used as Lewis acids for synthesis, we have been interested in exploration of catalysis based on rather unexplored organoiron chemistry since the late 1990s. This Perspective summarizes a series of iron-catalyzed C-C bond formation reactions developed by us, which include (asymmetric) carbomet

The B3LYP density functional studies on the dirhodium tetracarboxylate-catalyzed C-H bond activation/C-C bond formation reaction of a diazo compound with an alkane revealed the energetics and the geometry of important intermediates and transition states in the catalytic cycle. The reaction is initiated by complexation between the rhodium catalyst and the diazo compound. Driven by the back-donation from the Rh 4d(xz) orbital to the C[bond]N sigma*-orbital, nitrogen extrusion takes place to afford

Organocopper reagents provide the most general synthetic tools in organic chemistry for nucleophilic delivery of hard carbanions to electrophilic carbon centers. A number of structural and mechanistic studies have been reported and have led to a wide variety of mechanistic proposals, some of which might even be contradictory to others. With the recent advent of physical and theoretical methodologies, the accumulated knowledge on organocopper chemistry is being put together into a few major mecha

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTCarbon-carbon bond-forming reactions of zinc homoenolate of esters. A novel three-carbon nucleophile with general synthetic utilityEiichi Nakamura, Satoshi Aoki, Kouichi Sekiya, Hiroji Oshino, and Isao KuwajimaCite this: J. Am. Chem. Soc. 1987, 109, 26, 8056–8066Publication Date (Print):December 1, 1987Publication History Published online1 May 2002Published inissue 1 December 1987https://pubs.acs.org/doi/10.1021/ja00260a018https://doi.org/10.1021/ja002

Lead (II) perovskite (PV, e.g., CH3NH3PbI3–xClx) with 3 wt% polyvinylpyrrolidone (PVP) produces an ≈90 nm film containing a PVP–PV composite consisting of ≈15-nm-sized PV nanocrystals. Solar cells using 3 wt% PVP–PV have several advantages over a device using nondoped PV, which include an increase in transparency, stability of the film, efficiency, and reproducibility.

Abstract Two different classes of water-soluble fullerene derivatives, detergent-type and sphere-type, were synthesized. The derivatives were evaluated for their biological activities including cytotoxicity, DNA cleavage, and inhibition of HIV-protease and other enzymes. Both classes of compounds display generally similar behavior except for their cytotoxicity spectra against several cell lines. The fullerene derivatives bearing N-methylpyrrole were found to be photo-inactive with respect to DNA

The first hoop-shaped cyclic benzenoid compounds, [10]cyclophenacene derivatives that contain 40 pi electrons, have been synthesized in three or four steps from [60]fullerene by rationally designed chemical modification. The compounds thus synthesized are chemically stable, yellow-colored, luminescent, and EPR-silent. X-ray crystallographic analysis provided high precision structural data sets. On the basis of these results and theoretical investigations, the new cyclic benzenoid molecules were

A 99.5% void-free perovskite layer with a doped-P3HT hole-transporting layer showed the highest PCE among the P3HT based hybrid solar cells.