The University of Tokyo · 의학
이 교수의 연구실은 대사성 질환과 심혈관계 질환 간의 복합적 연관성에 초점을 맞추고 있으며, 특히 내피 기능 이상과 자율신경계 이상이 동맥경화증 발병에 미치는 상호작용 메커니즘을 규명하고자 합니다. 자유기초와 산화 스트레스, 지질 대사 이상이 내피세포 기능에 미치는 영향, 특히 라프트 미세도메인을 중심으로 한 신호전달 이상의 역할을 심층적으로 연구하고 있습니다. 또한 갑상선기능 항진증과 심부전 등 심혈관계 합병증의 병태생리학적 기전과 치료 반응성에 대한 기초 연구도 진행 중입니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Endothelial dysfunction and autonomic nervous system dysfunction are both risk factors for atherosclerosis. There is evidence demonstrating that there is a close interrelationship between these two systems. In hypertension, endothelial dysfunction affects the pathologic process through autonomic nervous pathways, and the pathophysiological process of autonomic neuropathy in diabetes mellitus is closely related with vascular function. However, detailed mechanisms of this interrelationship have no
Reactive oxygen species (ROS) and oxidative stress are closely associated with the development of atherosclerosis, and the most important regulator of ROS production in endothelial cells is NADPH oxidase. Activation of NADPH oxidase requires the assembly of multiple subunits into lipid rafts, which include specific lipid components, including free cholesterol and specific proteins. Disorders of lipid metabolism such as hyperlipidemia affect the cellular lipid components included in rafts, result
Vascular endothelial function is impaired in hypercholesterolemia partly because of injury by modified LDL. In addition to modified LDL, free cholesterol (FC) is thought to play an important role in the development of endothelial dysfunction, although the precise mechanisms remain to be elucidated. The aim of this study was to clarify the mechanisms of endothelial dysfunction induced by an FC-rich environment. Loading cultured human aortic endothelial cells with FC induced the formation of vesic
In NIDCM patients, prolonged QRS duration is a high risk factor for remodeling and unfavorable events. The severity of mitral regurgitation was also a strong risk predictor.
The abnormalities in uric acid concentration are common in a variety of clinical settings. Uric acid, a byproduct of purine metabolism, was influenced by several factors, such as high purine or protein diets, alcohol consumption, conditions with high cell turnover, drugs, renal dysfunction, or enzymatic defects in purine metabolism. Further, the development of hypertension,1 renal dysfunction,2 and cardiovascular events3 have all been linked to an increase in serum uric acid. In the mechanistic
The most outstanding feature of the current case was the rapid decrease of cardiac injury and improvement of cardiac function by strengthening antithyroid therapy, including steroid pulse, without thyroid hormone level normalization. In thyroid storm, various systemic inflammatory reactions have different time courses and among them, the cardiac phenotype emerges in most striking and critical ways.
To investigate the effect of atrial fibrillation (AF) on the oxygen uptake and exercise tolerance, we evaluated cardiopulmonary exercise test (CPET) data in AF patients and heart rate-matched controls with sinus rhythm (cSR) who received ambulatory cardiac rehabilitation. We compared CPET data between AF (<i>N</i> = 27) and cSR patients (<i>N</i> = 106) who had similar HRs at rest and the peak points. Oxygen uptake (VO<sub>2</sub>)/kg and relative O<sub>2</sub> pulse (ml/bpm/kg) at rest and the
