The University of Tokyo · 화학
이 교수의 연구실은 항산화제, 특히 비타민 E와 비타민 C의 상호작용 메커니즘과 생체 내에서의 항산화 작용 역학을 중심으로 연구를 진행하고 있습니다. 지질과 세밀한 생체막에서의 산화손상 방지 기전, 특히 지용성 및 수용성 항산화제의 상보적 작용과 그 생리적 조절 메커니즘을 규명하는 데 초점을 맞추고 있습니다. 또한 산화 스트레스와 관련된 질병의 생물학적 마커로 활용 가능한 지질 과산화 산물(예: 이소프rost란, 뉴로프로스타논)의 역할과 평가 방법에 대해서도 연구하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Vitamins C and E function as water-soluble and lipid-soluble chain-breaking antioxidants, respectively, and protect lipids, proteins, and membranes from oxidative damage. Vitamin C scavenges oxygen radicals in the aqueous phase, whereas vitamin E scavenges oxygen radicals within the membranes. Vitamin C regenerates vitamin E by reducing vitamin E radicals formed when vitamin E scavenges the oxygen radicals. This interaction between vitamin C and vitamin E radicals can take place not only in homo
Abstract α-Chromanoxyl radical formed by the interaction of α-tocopherol (vitamin E) with alkoxyl radical or DPPH was found by electron spin resonance spectroscopy to react with glutathione and vitamin C to regenerate α-tocopherol.
Oxidative stress induced by reactive oxygen and nitrogen species has been implicated in the pathogenesis of various disorders and diseases. Biomarkers are needed for assessment of oxidative stress status in vivo and also for health examination, diagnosis at early stage, prognosis, safe and efficient drug development, and evaluation of efficacy of drugs, foods, beverages, and supplements. Lipids are susceptible to oxidation and lipid peroxidation products are potential biomarkers for oxidative st
Vitamin E is the major lipophilic, radical-scavenging antioxidant in vivo and protects humans from the oxidative stress mediated by active oxygen and nitrogen species. The mechanisms of the inhibition of oxidation by vitamin E in vitro are now fairly well understood, but the dynamics of antioxidant action of vitamin E in vivo have not been well elucidated yet, primarily because of the inherent heterogeneity of biological systems. In this Account, the factors which determine the antioxidant capac
Vitamin E (α-tocopherol) was discovered nearly 100 years ago because it was required to prevent fetal resorption in pregnant, vitamin E-deficient rats fed lard-containing diets that were easily oxidizable. The human diet contains eight different vitamin E-related molecules synthesized by plants; despite the fact that all of these molecules are peroxyl radical scavengers, the human body prefers α-tocopherol. The biological activity of vitamin E is highly dependent upon regulatory mechanisms that
Abstract Vitamin E acted as an efficient antioxidant in the oxidation of soybean phosphatidylcholine liposome in an aqueous dispersion initiated by free radicals generated initially either in the aqueous phase or in the lipid phase. Vitamin E decayed linearly with time, and when it was exhausted, the oxidation proceeded rapidly at a similar rate to that in the absence of vitamin E. Vitamin C was also effective by itself in scavenging radicals in an aqueous phase, but it could not scavenge the ra
