Eun Young Lee
서울대학교 내과 · 의학
Eun Young Lee 교수의 연구실은 주로 금속-유기 프레임워크(MOFs)를 중심으로 한 다공성 나노소재의 설계 및 응용을 연구하고 있습니다. 고정성 다공성, 높은 열안정성, 기체 흡착 및 선택적 흡착 능력을 갖춘 새로운 MOF 구조를 개발하며, 특히 단결정성 유지 능력과 광학적 성질 조절을 통해 실용적 응용 가능성을 탐색하고 있습니다. 또한 염증성 관절염에서의 엑소좀 및 시트르룰린화 단백질의 역할을 규명하는 생물의학적 연구도 병행하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
A porous metal-organic framework [Zn(4)O(NTB)(2)].3DEF.EtOH (1), in which (3,6)-connected nets are doubly interpenetrated to generate curved three-dimensional channels, has been prepared. Framework 1 exhibits high permanent porosity (Langmuir surface area, 1121 m(2)/g; pore volume, 0.51 cm(3)/cm(3)), high thermal stability (up to 430 degrees C), high hydrogen adsorption capacity (1.9 wt % at 77 K and 1 atm), selective organic guest binding ability (K(f)()( )(): MeOH > pyridine > benzene > dodeca
Hole in one: A metal–organic framework with permanent microporosity has been constructed from linear coordination polymer chains consisting of [Ni(cyclam)]2+ and bpydc2−. In framework 1 the chains run in three directions (red, green, blue in the picture) and are stacked to form 1D channels that are filled with water molecules, which can be removed completely and reabsorbed with retention of the single crystallinity.
Löchrige Sache: Eine metallo-organische Architektur mit stabilen Mikroporen wurde aus eindimensionalen Koordinationspolymeren, bestehend aus [Ni(cyclam)]2+-Einheiten und bpydc2−-Liganden, aufgebaut. Im Netzwerk 1 sind in drei Richtungen verlaufende Ketten (rot, grün und blau, siehe Bild) zu Kanälen gestapelt. Wassermoleküle, die in diesen Kanälen adsorbiert sind, können unter Aufrechterhaltung der Einkristallinität entfernt und readsobiert werden.
This study aimed to investigate the characteristics of exosomes isolated from synovial fluid and their role in osteoclast differentiation in different types of inflammatory arthritis. Exosomes isolated from synovial fluid of rheumatoid arthritis (RA), ankylosing spondylitis (AS), gout, and osteoarthritis (OA) patients were co-incubated with CD14+ mononuclear cells from healthy donors without macrophage colony-stimulating factor (M-CSF) and receptor activator of nuclear factor kappa-B ligand (RAN
Most patients with RA-ILD experienced stable or slowly declining lung function. In 5% of patients, predicted FVC% deteriorated rapidly, especially in older adults with early RA. The lung function trajectory was not comparable to the RA disease activity trajectory.
Immune complexes containing citrullinated fibrinogen are present in the sera and synovium of rheumatoid arthritis patients and potentially contribute to synovitis. However, fibrinogen can inhibit the osteoclastogenesis of precursor cells. We investigated the direct effect of citrullinated fibrinogen on osteoclastogenesis to understand the role of citrullination on bone erosion of rheumatoid arthritis patients. We evaluated the fibrinogen citrullination sites using mass spectrometry and quantifie
