유자형 교수

For efficient drug delivery, stable encapsulation of a large amount of anticancer drugs is crucial, not to mention cell-specific delivery. Among many possible nanocarriers, mesoporous silica nanoparticles are versatile frameworks that satisfy those requirements owing to their characteristic internal pores with a large surface area and a tunable surface composition. By using a noncovalent post-modification strategy, MSN-based drug delivery systems with enhanced therapeutic efficiency can be prepa

Tumor hypoxia poses a significant challenge in photodynamic therapy (PDT), which uses molecular oxygen to produce reactive oxygen species upon light excitation of a photosensitizer. For hypoxia mitigation, an enzyme catalase (CAT) can be beneficially used to convert intracellular hydrogen peroxide to molecular oxygen, but its utility is significantly limited due to the intrinsic membrane impermeability. Herein, we present direct integration of CAT into the outer surface of unmodified metal-organ

In the field of drug-delivery research, mesoporous silica nanoparticles (MSNs) have received a great deal of attention because of their capability to load and release drug molecules through the internal mesopores. To maximize the biomedical applicability of MSN-based drug carriers, it is important to ensure their degradability in a physiological environment as well as to obtain MSNs with desirable physicochemical properties. We present in vitro degradability of drug-loaded MSNs (DMSNs) that cont

Abstract Mesoporous silica nanoparticles with a cubic ( Ia 3 d ) pore structure are derivatized with light‐activated nanoimpellers to control the release of loaded guest molecules under external photo‐control. The nanoimpellers consist of azobenzene derivatives that are attached to the interiors of the three‐dimensional interconnected pores, and undergo photoisomerization that results in dynamic wagging motions of the unbound termini and drives the expulsion of molecules from the pores. Stimulat

Chemotherapy using a nanoscaled drug delivery system is an effective cancer therapy, but its high drug concentration often causes drug resistance in cancer cells and normal cell damage. Combination therapy involving two or more different cell signaling pathways can be a powerful tool to overcome the limitations of chemotherapy. Herein, this article presents nanogel (NG)-mediated co-delivery of a chemodrug camptothecin (CPT) and mitochondria-targeting monomer (MT monomer) for efficient activation

Simultaneous silencing of multiple apoptosis-related genes is an attractive approach to treat cancer. In this article, we present a multiple gene-targeting siRNA/drug delivery system for prostate cancer treatment with a high efficiency. Bcl-2, survivin, and androgen receptor genes involved in the cell apoptosis pathways were chosen as silencing targets with three different siRNAs. The colloidal nanocomplex delivery system (<10 nm in size) was formulated electrostatically between anionic siRNAs a

In the recent biomedical research, mesoporous silica nanoparticles (MSNs) prepared by sol-gel chemistry have useful applications in cancer treatment. This is because of several attractive aspects of the MSN such as uniform pores with tunable size, large surface area, ease in functionalization, and biocompatibility. Also when the pores are functionalized with organic molecules that are stimuli-responsive, a controlled release system can be obtained for storage and delivery of a wide range of drug

Abstract For the construction of a nanoparticle (NP)‐supported drug delivery system (DDS), loading efficiency, stable encapsulation, and targeted delivery are considered crucial to achieve a high therapeutic outcome of the resulting system. Conventionally, NPs are functionalized with desired molecules via covalent interactions, which do not only limit the intraparticle space for drug loading but also cause significant loss of the preloaded drug through the multistep chemical reactions. Furthermo