Kyoto University · 의학
Fumiyoshi Yamashita 교수의 연구실은 약물 개발의 임상 실패 원인 중 하나인 ADME(흡수, 분포, 대사, 배설) 성질 예측에 초점을 맞추고 있습니다. 특히 인 비트로 실험 데이터를 기반으로 한 CYP3A4 효소 유도 메커니즘 모델링과 약물 상호작용 예측 기술을 개발하며, 약물의 안전성과 효능을 사전에 평가하는 시뮬레이션 기반 접근을 선도하고 있습니다. 또한, 환경 오염물질이 태아에 미치는 영향을 분석한 '태반성 PCB 증후군(Fetal PCB Syndrome)' 연구를 통해 환경독소의 발달독성 메커니즘을 규명하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Combinatorial chemistry and high-throughput screening have increased the possibility of finding new lead compounds at much shorter time periods than conventional medicinal chemistry. However, too much promising drug candidates often fail because of unsatisfactory ADME properties. In silico ADME studies are expected to reduce the risk of late-stage attrition of drug development and to optimize screening and testing by looking at only the promising compounds. To this end, many in silico approaches
Pregnant mothers with yusho in Fukuoka, Nagasaki and Kochi Prefectures delivered babies with a peculiar clinical manifestation which will be called fetal PCB syndrome (FPS). The birth rate incidences were 3.6% (Fukuoka Prefecture), 4% (Nagasaki Prefecture), 2.9% (Kochi Prefecture) and 3.9% (total). The manifestations consisted of dark brown pigmentation of the skin and the mucous membrane, gingival hyperplasia, exophthalmic edematous eye, dentition at birth, abnormal calcification of the skull a
Induction of cytochrome P450 3A4 (CYP3A4) expression is often implicated in clinically relevant drug-drug interactions (DDI), as metabolism catalyzed by this enzyme is the dominant route of elimination for many drugs. Although several DDI models have been proposed, none have comprehensively considered the effects of enzyme transcription/translation dynamics on induction-based DDI. Rifampicin is a well-known CYP3A4 inducer, and is commonly used as a positive control for evaluating the CYP3A4 indu
Fumio Yamashita, Masao Hayashi, Fetal PCB Syndrome: Clinical Features, Intrauterine Growth Retardation and Possible Alteration in Calcium Metabolism, Environmental Health Perspectives, Vol. 59 (Feb., 1985), pp. 41-45
