東京工業大学 · Materials Science
Konishi 교수의 연구실은 고도로 발달한 발광 물질, 특히 집합유도발광(AIE) 원리에 기반한 신소재 개발에 집중하고 있습니다. 주로 피리딘, 안트라센 유도체를 기반으로 한 고효율·고안정성 루미노포어를 설계하여 의료 영상, 질병 진단, 두광형광현미경 등 생물의학적 응용을 목표로 하고 있습니다. 특히 조직 깊이까지 침투 가능한 두광자극 형광 소재 개발과 함께, 용매 친화성과 큰 Stokes 이동을 동시에 확보한 신규 유형의 형광 염료 개발에도 주력하고 있습니다.
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
Light has profoundly impacted modern medicine and healthcare, with numerous luminescent agents and imaging techniques currently being used to assess health and treat diseases. As an emerging concept in luminescence, aggregation-induced emission (AIE) has shown great potential in biological applications due to its advantages in terms of brightness, biocompatibility, photostability, and positive correlation with concentration. This review provides a comprehensive summary of AIE luminogens applied
Twenty years ago, the concept of aggregation-induced emission (AIE) was proposed, and this unique luminescent property has attracted scientific interest ever since. However, AIE denominates only the phenomenon, while the details of its underlying guiding principles remain to be elucidated. This minireview discusses the basic principles of AIE based on our previous mechanistic study of the photophysical behavior of 9,10-bis(N,N-dialkylamino)anthracene (BDAA) and the corresponding mechanistic anal
True colors: Novel pyrene analogues of Prodan exhibit outstanding photophysical properties with remarkably high fluorescence quantum yield (QY) in solvents ranging from apolar hexane to polar methanol (see figure). This is accompanied by strong solvatochromism and large Stokes shifts. These properties have not been previously achieved in enormous solvatochromic dyes, but are quite useful for emitting materials and imaging tools.
Highly efficient luminescence dyes based on pyrene and anthracene derivatives (see figure) are synthesized for liquid crystal dye lasers. The threshold value of one of the pyrene derivatives is as low as 1/20 that of the commonly used DCM in cholesteric liquid crystal (CLC) distributed feedback lasers. Good optical properties such as luminous efficiency and solubility in CLCs are important factors for realizing a low threshold. Detailed facts of importance to specialist readers are published as
Bis(piperidyl)anthracenes were developed as structurally simple, bright and colour tuneable AIE luminogens and their emission mechanisms were analysed.
The development of two-photon (TP) active fluorophores remains an important issue. Dyes that can be excited and fluoresce efficiently in the 'tissue optical window' (650-1100 nm) are especially in demand to maximize the underlying performance of two-photon fluorescence microscopy (TPFM) as an advanced optical technique. Ideally, such dyes would be compatible with the 1050 nm femtosecond fibre laser, which has recently been developed as an inexpensive excitation source to make the TPFM technique
We designed a liquid-crystalline bistolane with alkylsulfanyl and isothiocyanate groups that exhibited an extremely high birefringence (0.77 at 550 nm).
We synthesized two series of diphenyl-diacetylene (DPDA)-based materials with alkoxy and alkyl tails of length m (DPDA–OCm and DPDA–Cm, respectively), and measured their nematic-phase birefringence (Δn) as a function of wavelength and temperature. We found that Δn decreases with an increase in m, possibly by a dilution effect of the low-Δn alkyl tail. Further, of the two series, Δn was found to be relatively higher in the DPDA–OCm materials, with the highest value of 0.4 obtained for DPDA–OC1 at
Abstract Twenty years ago, the concept of aggregation‐induced emission (AIE) was proposed, and this unique luminescent property has attracted scientific interest ever since. However, AIE denominates only the phenomenon, while the details of its underlying guiding principles remain to be elucidated. This minireview discusses the basic principles of AIE based on our previous mechanistic study of the photophysical behavior of 9,10‐bis(N,N‐dialkylamino)anthracene ( BDAA ) and the corresponding mecha
We designed novel bistolane-based alkylsulfanyl derivatives with well-defined nematic liquid crystalline and high birefringence.
A novel pyrene-based D–π–A dye consisting of piperidine (D) and a secondary N-alkyl carboxamide (A) was prepared. This dye showed solvatochromism and bright fluorescence in solvents with a wide range of polarities, including water. Such emission properties are derived from the role of the secondary N-alkyl carboxamide group as both a weak acceptor and a stabilizer of the n electrons on the carbonyl group.
To broaden the application of aggregation-induced emission (AIE) luminogens (AIEgens), the design of novel small-molecular dyes that exhibit high fluorescence quantum yield (Φ<sub>fl</sub> ) in the solid state is required. Considering that the mechanism of AIE can be rationalized based on steric avoidance of non-radiative decay pathways, a series of bridged stilbenes was designed, and their non-radiative decay pathways were investigated theoretically. Bridged stilbenes with short alkyl chains ex
